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Overexpression of LIN7 or IRSp53 (show BAIAP2 Antibodies) did not prevent the formation of hyperfused mitochondria in cells coexpressing the Drp1 (show CRMP1 Antibodies) K38A mutant, thus suggesting that LIN7-IRSp53 (show BAIAP2 Antibodies) complex requires functional Drp1 (show CRMP1 Antibodies) to regulate mitochondrial morphology.
This study therefore shows that LIN7A has a crucial role in the polarity abnormalities associated with breast carcinogenesis.
LIN7A depletion disrupts cerebral cortex development, contributing to intellectual disability in 12q21-deletion syndrome.
coordinated folding and association of the LIN-2, -7 domain
LIN7A is a PDZ protein (show INADL Antibodies) that interacts with human papillomavirus-16 E6 and forms a tripartite complex with MPP7 (show CHAF1B Antibodies) and DLG1 (show DLG1 Antibodies), regulating the stability and localization of DLG1 (show DLG1 Antibodies) to cell junctions.
Allelic and haplotype association was found between both BDNF (show BDNF Antibodies) and adult ADHD, and LIN-7 and adult ADHD.
LIN7 is a novel regulator of IRSp53 (show BAIAP2 Antibodies).
analysis of structures of tetrameric L27 (show RPL27A Antibodies) domain complexes formed by mLin-2 (show CASK Antibodies)/mLin-7 and Patj (show INADL Antibodies)/Pals1 (show MPP5 Antibodies) scaffold proteins
LIN7-IRSp53 (show BAIAP2 Antibodies) association plays a role during assembly of functional tight junctions and surface polarization in epithelial cells
findings show that AQP1 plays a role inside the cells through Lin-7/beta-catenin interactionsuggesting that AQP1 plays a global physiological role
may mediate the formation of cell-cell junctions
, mammalian LIN-7 1
, mammalian lin-seven protein 1
, protein lin-7 homolog A
, tax interaction protein 33
, vertebrate LIN7 homolog 1
, vertebrate lin-7 homolog 1
, neuroepithelial polarity protein
, lin 7 homolog a
, vertebrate homolog of C. elegans Lin-7 type 1
, veli-1 protein