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anti-Human LRRTM2 Antibodies:
anti-Mouse (Murine) LRRTM2 Antibodies:
anti-Rat (Rattus) LRRTM2 Antibodies:
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Human Monoclonal LRRTM2 Primary Antibody for ICC, IHC - ABIN2115246
Calafate, Buist, Miskiewicz, Vijayan, Daneels, de Strooper, de Wit, Verstreken, Moechars: Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation. in Cell reports 2015
CTNNA1 (show CTNNA1 Antibodies) and CTNNA2 (show CTNNA2 Antibodies) contain alternative 5' exons linked to bidirectional promoters that are shared with the antisense oriented LRRTM2 and LRRTM1 (show LRRTM1 Antibodies) genes, respectively.
Genetic deletion of LRRTM1,2 in vivo in CA1 (show CA1 Antibodies) neurons using Cre recombinase (show RAG1 Antibodies)-expressing lentiviruses dramatically impaired long-term potentiation (LTP (show SCP2 Antibodies)), an impairment that was rescued by simultaneous expression of LRRTM2, but not LRRTM4 (show LRRTM4 Antibodies).
The crystal structure of a thermostabilized LRRTM2 protein was determined.
Data indicate that neural Cell Adhesion Molecules Lrrtm1 (show LRRTM1 Antibodies) and Lrrtm2 mRNA expression is controlled by synaptic activity and nuclear calcium signaling.
This study demonistrated that LRRTM2 is essential for maintenance of long-term potentiation in mice hippocampus.
The LRRTM2 acts redundantly to maintain excitatory synapses and that synapse elimination caused by the absence of LRRTM2 is promoted by synaptic activity and mediated by a postsynaptic Ca(2+)/CaM-dependent signaling pathway.
Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B.
leucine rich repeat transmembrane neuronal 2
, leucine-rich repeat neuronal 2 protein
, leucine-rich repeat transmembrane neuronal 2 protein
, leucine-rich repeat transmembrane neuronal protein 2