No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Rat (Rattus) Antibodies:
anti-Mouse (Murine) Antibodies:
Go to our pre-filtered search.
The relationship between partial orexin neurodegeneration and a sub-narcoleptic phenotype depends on the dynamics of progressive orexin A cell loss.
PLAGL1 may regulate hypothalamic hypocretin transcription.
We propose that this local GABAergic input inhibits orexin neurons during sleep but that, during wakefulness, this input is depressed, possibly through cholinergically mediated disinhibition
Activation of orexin system facilitates anesthesia emergence and pain control.
Treatment with the orexin-1 receptor antagonist SB334867 increased the activity of basolateral amygdala neurons projecting to infralimbic medial prefrontal cortex during fear extinction. GABAergic interneurons expressing calbindin, but not parvalbumin, were also activated by orexin-1 receptor antagonism in the basolateral amygdala.
Abeta and tau may be considered as novel biomarkers of sleep disorder in AD pathology, and that they function by regulating the expression levels of orexin A and adenosine A1R.
The results of this study suggested that hypocretin deficient mice may display signs of resilience to cocaine addiction.
Noradrenergic neurons in the locus coeruleus (NA(LC) neurons) projecting to the lateral amygdala (LA) receive synaptic input from orexin neurons.
Hcrt loss in Hcrt(ko/ko) mice causes impaired TDW maintenance in baseline wake and blunted delta power in SWS, reproducing, respectively, narcolepsy excessive daytime sleepiness and poor sleep quality
The results of this study suggest that the expression of orexin peptides precedes the maturation of electrophysiological activity of orexin neurons. The function of orexin neurons gradually matures by 3 weeks after birth.
This study demonstrated that the Neurochemical Heterogeneity Among Lateral Hypothalamic Hypocretin/Orexin and Melanin-Concentrating Hormone Neurons.
Furthermore, immunohistochemical analysis revealed that linalool activated hypothalamic orexin neurons, one of the key mediators for pain processing. Formalin tests in orexin neuron-ablated and orexin peptide-deficient mice showed orexinergic transmission was essential for linalool odour-induced analgesia.
The findings of this study suggest an important role of orexin in brain areas involved in anxiety
In ORX-KO mice, the ultradian episodic changes in locomotor activity, EEG arousal indices and body temperature were significantly attenuated, but the ultradian patterning was preserved. Findings suggest that the ultradian pattern is common across species and that orexin contributes to driving ultradian episodic changes, however, this neuropeptide is not essential for ultradian pattern generation.
OXA and OX1R are expressed in the testis and that they may help in proliferation and development of germ cells, Leydig cells and Sertoli cells, and in the spermatogenic process and steroidogenesis.
Results thus suggest that type 1 diabetes mellitus impairs testicular steroidogenesis and glucose homeostasis through inhibition of orexin A/OX1R signaling cascade due to decreased OX1R expression in adult mice, thereby affecting germ cell survival and their proliferation in the testis.
Binding of OXA to OX1R is important for the development of the testis.
Results suggest that orexin A bidirectionally modulates hippocampal CA1 synaptic plasticity, inhibiting long-term potentiation via OX1Rs at moderate concentrations while inducing re-potentiation via OX1Rs and OX2Rs, possibly through phospholipase C and adenylyl cyclase-protein kinase A signaling at sub-nanomolar concentrations
DYN-A(2-17) interacts with orexin A in the paraventricular hypothalamic nucleus to modulate food intake in mice.
Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin/hypocretin networks have been discovered.
Silence of OX1R completely abolished the inhibitory function of orexin in attachment of THP-1 cells. Collectively, our data suggest that orexin A ameliorated endothelial dysfunction under inflammatory stimuli.
HCRT neurotransmission promotes operant responding for both drug and non-drug rewards.
T cells in patients with narcolepsy target self-antigens of hypocretin neurons; findings solidify the autoimmune aetiology of narcolepsy and provide a basis for rapid diagnosis and treatment of this disease
Like OX1R, OX2R has an N-terminal helix important for binding the orexin peptide.
this study, both Perry syndrome and MSA had significantly reduced orexin immunoreactivity in the nucleus basalis of Meynert.
Orexin A levels correlated with age in females and were significantly elevated in PWS even after these effects were controlled. These findings support the hypothesis that dysregulation of orexin signaling may contribute to behavioral problems and hyperphagia in PWS.
Orexin levels do not play a role in the control of nocturnal blood pressure dipping in patients with narcolepsy type 1.
No association was observed between rs9902709 in HCRT and OSAHS (obstructive sleep apnea) risk in Chinese Han population.
findings show that in few patients with narcolepsy with cataplexy, symptoms and CSF hypocretin-1 and histamine levels can change over time
The plasma orexin-A level was associated with physical activity in obese and overweight people, including many aspects of daily life, such as working, domestic work, and walking especially.
Orexin-A is associated with increased phosphorylated P-Tau in normal elderly individuals. Increases in orexin-A and P-Tau might be a consequence of the reduction in the proportion of the deeper, more restorative slow wave sleep and rapid eye movement sleep reported with aging.
actigraphy gives additional information about the stabilization of sleep in patients with narcolepsy type 1; very low hypocretin levels associate with more wake intruding into sleep
Exercise induced a significant increase in plasmatic orexin A with a peak at 3o minutes.
There was also a negative correlation between Epworth sleepiness scale scores and orexin levels in Prader-Willi syndrome patients. Decreased cerebrospinal fluid orexin levels in Prader-Willi syndrome may play an important role in severity of obesity and excessive daytime sleepiness.
orexin system may be involved even in the earliest stages of AD, resulting in prolonged sleep latency, reduced sleep efficiency, and REM sleep impairment.
Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation is highly unlikely to be caused by mutations in the exons of the gene for hypocretin.
Data indicate a positive correlation of nesfatin-1 and a negative correlation of orexin-A with body mass index.
This study showed that orexin A induced autophagy through the ERK pathway in HCT116 human colon cancer cells.
The aim of the study was to determine by immunochemistry the expression of leptin, orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.
Orexin A was found in the beta cells of cattle, sheep, and swine where it may be implicated in the control of pancreatic activity.
locally synthesized in the urethroprostatic complex
first evidence for the expression of oxA and ox1R in the vestibular glands of mammalian genital tract
In summary, we revealed an important role of orexin A in the regulation of pancreatic islets biology. OxA is involved in the secretion of pancreatic hormones and prolongation of islet cell lifespan.
MBH, signal intensity for OXA was highest on days 14-16.
The impact of the phase of the estrous cycle on the observed changes in plasma orexin levels in domestic pigs.
Prepro-orexin (PPOX) mRNA abundance was approximately 15-fold higher (P<0.05) in mandibular than in the others salivary glands.
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.
Hypocretin (orexin) neuropeptide
, orexin A
, orexin B