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Hcrt (show OX Antibodies) loss in Hcrt (show OX Antibodies)(ko/ko (show KRT8 Antibodies)) mice causes impaired TDW maintenance in baseline wake and blunted delta power in SWS (show PNPLA6 Antibodies), reproducing, respectively, narcolepsy excessive daytime sleepiness and poor sleep quality
The results of this study suggest that the expression of orexin (show OX Antibodies) peptides precedes the maturation of electrophysiological activity of orexin (show OX Antibodies) neurons. The function of orexin (show OX Antibodies) neurons gradually matures by 3 weeks after birth.
This study demonstrated that the Neurochemical Heterogeneity Among Lateral Hypothalamic Hypocretin/Orexin (show OX Antibodies) and Melanin-Concentrating Hormone (show PMCH Antibodies) Neurons.
Furthermore, immunohistochemical analysis revealed that linalool activated hypothalamic orexin (show OX Antibodies) neurons, one of the key mediators for pain processing. Formalin tests in orexin (show OX Antibodies) neuron-ablated and orexin (show OX Antibodies) peptide-deficient mice showed orexinergic transmission was essential for linalool odour-induced analgesia.
The findings of this study suggest an important role of orexin (show OX Antibodies) in brain areas involved in anxiety
In ORX-KO mice, the ultradian episodic changes in locomotor activity, EEG arousal indices and body temperature were significantly attenuated, but the ultradian patterning was preserved. Findings suggest that the ultradian pattern is common across species and that orexin contributes to driving ultradian episodic changes, however, this neuropeptide is not essential for ultradian pattern generation.
OXA and OX1R (show HCRTR1 Antibodies) are expressed in the testis and that they may help in proliferation and development of germ cells, Leydig cells and Sertoli cells, and in the spermatogenic process and steroidogenesis.
Results thus suggest that type 1 diabetes mellitus impairs testicular steroidogenesis and glucose homeostasis through inhibition of orexin A/OX1R (show HCRTR1 Antibodies) signaling cascade due to decreased OX1R (show HCRTR1 Antibodies) expression in adult mice, thereby affecting germ cell survival and their proliferation in the testis.
Binding of OXA to OX1R (show HCRTR1 Antibodies) is important for the development of the testis.
Results suggest that orexin A bidirectionally modulates hippocampal CA1 (show CA1 Antibodies) synaptic plasticity, inhibiting long-term potentiation via OX1Rs at moderate concentrations while inducing re-potentiation via OX1Rs and OX2Rs, possibly through phospholipase C (show PLC Antibodies) and adenylyl cyclase-protein kinase A signaling at sub-nanomolar concentrations
The impact of the phase of the estrous cycle on the observed changes in plasma orexin (show OX Antibodies) levels in domestic pigs.
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
, orexin A
, orexin B