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The findings of this study suggest an important role of orexin (show OX Antibodies) in brain areas involved in anxiety
In ORX-KO mice, the ultradian episodic changes in locomotor activity, EEG arousal indices and body temperature were significantly attenuated, but the ultradian patterning was preserved. Findings suggest that the ultradian pattern is common across species and that orexin contributes to driving ultradian episodic changes, however, this neuropeptide is not essential for ultradian pattern generation.
OXA and OX1R (show HCRTR1 Antibodies) are expressed in the testis and that they may help in proliferation and development of germ cells, Leydig cells and Sertoli cells, and in the spermatogenic process and steroidogenesis.
Results thus suggest that type 1 diabetes mellitus impairs testicular steroidogenesis and glucose homeostasis through inhibition of orexin A/OX1R (show HCRTR1 Antibodies) signaling cascade due to decreased OX1R (show HCRTR1 Antibodies) expression in adult mice, thereby affecting germ cell survival and their proliferation in the testis.
Binding of OXA to OX1R (show HCRTR1 Antibodies) is important for the development of the testis.
Results suggest that orexin A bidirectionally modulates hippocampal CA1 (show CA1 Antibodies) synaptic plasticity, inhibiting long-term potentiation via OX1Rs at moderate concentrations while inducing re-potentiation via OX1Rs and OX2Rs, possibly through phospholipase C (show PLC Antibodies) and adenylyl cyclase-protein kinase A signaling at sub-nanomolar concentrations
DYN (show PDYN Antibodies)-A(2-17) interacts with orexin A in the paraventricular hypothalamic nucleus to modulate food intake in mice.
Awake dynamics and brain-wide direct inputs of hypothalamic MCH (show PMCH Antibodies) and orexin/hypocretin (show OX Antibodies) networks have been discovered.
Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin (show OX Antibodies) Neuron Deficiency
observation that inhibition of the Orexin (show OX Antibodies)-1 receptor signaling blunted binge-like Ethanol, and saccharin drinking suggests that reward-related Orexin (show OX Antibodies) circuits participate in the consumption of salient reinforcers regardless of calories.
The impact of the phase of the estrous cycle on the observed changes in plasma orexin (show OX Antibodies) levels in domestic pigs.
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
, orexin A
, orexin B