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anti-Human S1PR2 Antibodies:
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Human Polyclonal S1PR2 Primary Antibody for IHC (p), WB - ABIN4351849
Kempf, Tews, Arzt, Weinmann, Obermair, Pernet, Zagrebelsky, Delekate, Iobbi, Zemmar, Ristic, Gullo, Spies, Dodd, Gygax, Korte, Schwab: The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. in PLoS biology 2014
Show all 2 Pubmed References
Human Polyclonal S1PR2 Primary Antibody for IF, IHC (p) - ABIN317633
Danieli-Betto, Peron, Germinario, Zanin, Sorci, Franzoso, Sandonà, Betto: Sphingosine 1-phosphate signaling is involved in skeletal muscle regeneration. in American journal of physiology. Cell physiology 2010
Show all 2 Pubmed References
Human Monoclonal S1PR2 Primary Antibody for CyTOF, FACS - ABIN4899079
Capitani, Patrussi, Trentin, Lucherini, Cannizzaro, Migliaccio, Frezzato, Gattazzo, Forconi, Pelicci, Semenzato, Baldari: S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavorable prognosis. in Blood 2012
Dog (Canine) Polyclonal S1PR2 Primary Antibody for ELISA, WB - ABIN4242993
McGeachie, Ramoni, Mychaleckyj, Furie, Dreyfuss, Liu, Herrington, Guo, Lima, Post, Rotter, Rich, Sale, Ramoni: Integrative predictive model of coronary artery calcification in atherosclerosis. in Circulation 2009
Human Polyclonal S1PR2 Primary Antibody for EIA, IF - ABIN317746
Huang, Liu, Lan, Xie, Peng, Huang, Wang, Shen, Liu, Huang: Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models. in PLoS ONE 2012
Although extravillous trophoblasts express three S1P (show MBTPS1 Antibodies) receptor isoforms, S1P (show MBTPS1 Antibodies) predominantly signals through S1PR2/Galpha12 (show GNA12 Antibodies)/13 to activate Rho, and thereby acts as potent inhibitor of extravillous trophoblast migration.
Butyrate and bioactive proteolytic form of Wnt-5a (show WNT5A Antibodies) regulate colonic epithelial proliferation and spatial development
SNPs within 0.1 Mb of the S1PR2 gene as well as within the gene itself were interrogated as a candidate gene association for hearing loss. For 1 kHz thresholds, the adjacent SNP rs74930654 showed the most significant association. For 4 kHz, the most significant association was with rs201930568. These findings suggest that variants affecting the S1PR2 gene do contribute to auditory thresholds in the UK population.
Data show that sphingosine kinase 1 (SPHK1 (show SPHK1 Antibodies)) was significantly upregulated in oral squamous cell carcinoma (OSCC) tissues and low levels of sphingosine-1-phosphate lyase 1 (SGPL1 (show SGPL1 Antibodies)) mRNA correlated with a worse overall survival, and that sphingosine-1-phosphate receptor 2 (S1PR2) is over-expressed in a subset of tumours, which in part mediates sphingosine 1-phosphate (S1P (show MBTPS1 Antibodies))-induced migration of OSCC cells.
High S1PR2 expression is associated with anti-neutrophil cytoplasmic antibody-associated vasculitis.
CONCLUSION: MiR (show MLXIP Antibodies)-126 down-regulated S1PR2 and then prevented the activation of PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling pathway, which ultimately could damage intestinal mucosal barrier function.
Data suggest that activation of SR-BI (show SCARB1 Antibodies) by APOAI down-regulates sphingosine 1-phosphate/S1PR2-mediated inflammation in vascular endothelial cells by activating the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) signaling pathway; oxidized-LDL does the opposite. (APOA1 (show APOA1 Antibodies) = apolipoprotein A-I (show APOA1 Antibodies); SR-BI/SCARB1 (show SCARB1 Antibodies) = scavenger receptor class B type I; S1PR2 = sphingosine 1-phosphate receptor 2; PI3K (show PIK3CA Antibodies) = phosphatidylinositol 3-kinase; Akt (show AKT1 Antibodies) = proto-oncogene c-akt (show AKT1 Antibodies))
S1PR2 mediates Rho activation in normal cells neighboring RasV12-transformed cells.
Sphingosine 1-phosphate-induced IL-8 (show IL8 Antibodies) gene expression is mainly regulated via S1PR(1 (show S1PR1 Antibodies)), and its secretion is regulated through S1PR(2) receptor subtype.
S1PR2 is repressed by FOXP1 (show FOXP1 Antibodies) in activated B-cell and germinal center B-cell DLBCL cell lines with aberrantly high FOXP1 (show FOXP1 Antibodies) levels; S1PR2 expression is further inversely correlated with FOXP1 (show FOXP1 Antibodies) expression in 3 DLBCL patient cohorts.
A new spontaneous mouse mutation (stonedeaf, stdf ) leading to recessive, early-onset progressive hearing loss was detected and exome sequencing revealed a Thr289Arg substitution in S1pr2. Endocochlear potential (EP) was normal at 2 weeks old but was reduced by 4 and 8 weeks old in mutants, and the stria vascularis, which generates the EP, showed degenerative changes.
Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2 (show RUNX2 Antibodies)) expression through S1PR2/RhoA (show RHOA Antibodies)/ROCK/Smad1 (show SMAD1 Antibodies)/5/8 signaling.
Results provide evidence that S1PR2 plays an essential role in modulating proinflammatory cytokine production and osteoclastogenesis.
activation of S1P2 with a selective receptor agonist increases cell viability and reduces cisplatin-mediated cell death by reducing ROS (show ROS1 Antibodies). Cumulatively, these results suggest that S1P2 may serve as a therapeutic target for attenuating cisplatin-mediated ototoxicity.
S1P2 receptor is a key signaling molecule in the S1Pdependent inhibition of adipogenic differentiation.
S1PR2, as a critical receptor in macrophages, impairs phagocytosis and antimicrobial defense in the pathogenesis of sepsis.
These results suggest that S1PR2 and CXCR5 (show CXCR5 Antibodies) cooperatively regulate localization of Tfh cells in GCs (show UGCG Antibodies) to support GC responses
The sphingolipid receptor S1PR2 is a receptor for Nogo-a (show RTN4 Antibodies) repressing synaptic plasticity.
S1PR2 expression was increased in disease-susceptible regions of the CNS of female SJL EAE mice compared with their male counterparts.
IL-6 (show IL6 Antibodies) increased the number of osteoclast precursor cells in tibial bone marrow via up-regulating S1PR2, thus playing a crucial role in systemic bone loss induced by inflammation.
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation
sphingosine-1-phosphate receptor 2
, sphingosine 1-phosphate receptor 2-like
, S1P receptor 2
, S1P receptor EDG5
, S1P receptor Edg-5
, endothelial differentiation G-protein coupled receptor 5
, endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
, sphingosine 1-phosphate receptor 2
, sphingosine 1-phosphate receptor Edg-5
, G-protein coupled receptor 13
, lysophospholipid receptor B2
, sphingosine-1-phosphate receptor S1P(2)
, G-protein coupled receptor H218