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Knock down serotonin receptors 5-HTR3 and 5-HTR4 (show HTR4 Proteins) in neonatal cardiomyocytes resulted in significant increase of cell damage in response to hypoxia, and also led to alternation in heart beating.
analysis of the structure from the full-length 5-HT3AR channel in the apo (show C9orf3 Proteins)-state determined by single-particle cryo-electron microscopy
Transmission of sour taste information involves communication between taste cells and 5-HT3A-expressing afferent nerve fibers.
the recently available murine 5-HT3 receptor by identifying sites of strong interaction with particular functional groups at both the orthogonal (serotonin) site and a proposed allosteric binding site situated at the interface between the transmembrane region and the extracellular domain, was characterized.
We conclude that cholera toxin inhibits colonic migrating motor complexes via release of mucosal 5-HT (show DDC Proteins), which activates an inhibitory pathway involving 5-HT3 receptors
It was concluded that epithelial 5-HT3 receptor may function as a mediator of gut (show GUSB Proteins) microbiota-driven change in intestinal secretion.
5HT3A receptor deletion in neuroblasts impaired speed and directionality of migration and abolished calcium spikes.
Studies with 16 arylguanidines found that their functional activity spanned a broad spectrum from superagonist to full agonist, partial agonist, and antagonist at 5-HT3 receptors; results confirm the utility of phenylguanidine as an extremely versatile scaffold in the design of 5-HT3 ligands with a "tunable" level of agonist or antagonist activity
5-HT3A-ICD is not only required but also sufficient for interaction with RIC-3
found the protein levels of AMPA (show GRIA3 Proteins) receptor subunits (GluR1 (show GRIA1 Proteins) and GluR2 (show GRIA2 Proteins)) are upregulated in the amygdala and the 5-HT3 receptor is downregulated in hypothalamic regions of Socially Isolated mice.
This study demonstrated that the C and E subunits when assembled as simple or complex heteromeric 5-HT3 receptors may alter efficacies of serotonin and clinically used antagonists.
Methylation status of the HTR3A gene in mothers is linked to maternal violence-related psychopathology, trauma-induced brain activation patterns, and child attachment disturbance during a sensitive period in the development of self-regulation.
This study did not found HTR3A play a major role in predicting Antipsychotic-Induced Weight Gain.
Methylation pattern changes in the 5-HTR3A gene were associated with suicidal behavior in borderline personality disorder, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD).
findings suggest that HTR3A mRNA expression levels were positively correlated with craving in Han Chinese alcohol-dependent patients.
Study provides structural data showing the orientation of palonosetron in a 5-HT3 receptor binding site mimic, combined with functional data in the 5-HT3 receptor, provide an explanation for the high affinity and long-lived actions of this compound. These are likely due to specific interactions formed with binding site residues, and its location as a tight and effective wedge in the binding pocket.
Studies have demonstrated that 5-HT3 receptors modulate the activity of vascular and non-vascular smooth muscles.
The HTR3A rs1062613 polymorphisms do not seem to directly influence experimental muscle pain in healthy individuals. However, women reported higher pain intensity and larger pain area than men, which might partly be attributed to genotype.
Analysis of our small Chinese sample revealed a significant association of HTR3A with bipolar disorder, but yielded no evidence of an association between HTR3B (show HTR3B Proteins) and bipolar disorder. Furthermore, evidence for an association was found for a haplotype of HTR3A.
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.
5-hydroxytryptamine (serotonin) receptor 3A
, 5-hydroxytryptamine receptor 3A
, 5-HT3 receptor
, 5-hydroxytryptamine receptor 3A-like
, 5-hydroxytryptamine receptor 3
, 5HT3 serotonin receptor
, serotonin receptor 3A
, serotonin-gated ion channel receptor
, 5-HT3-Al receptor
, 5-hydroxytryptamine type 3A receptor