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Human Polyclonal SNTA1 Primary Antibody for ELISA, WB - ABIN250089
Fernández-Larrea, Merlos-Suárez, Ureña, Baselga, Arribas: A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface. in Molecular cell 1999
Ordered disorder of the astrocytic dystrophin (show DMD Antibodies)-associated protein complex in the norm and pathology.
Data indicate that alpha-syntrophin plays an important role in the regulation of oxidative stress from endogenously generated reactive oxygen species (ROS (show ROS1 Antibodies)) during myoblast differentiation by modulating the protein stability of catalase (show CAT Antibodies).
alpha-syntrophin plays a pivotal role in the survival pathway triggered by menadione-induced oxidative stress in cultured myoblasts.
Alpha-syntrophin deficiency markedly reduces astrocyte swelling during severe hypoosmotic stress/brain edema.
Isolated muscle bundles from SNTA1 mutant mice showed reduced force production after hypo-osmotic shock. In addition, the mutant muscle bundles showed delayed recovery of specific gravity after being exposed to hypo-osmotic conditions.
alpha-Syntrophin, which resides in nuclei of myocytes, functions as the upstream mediator of nuclear nNOS (show NOS1 Antibodies) translocation and nNOS (show NOS1 Antibodies)-dependent mitochondrial biogenesis.
the removal of the perivascular pool of AQP4 (show AQP4 Antibodies) due to alpha-syntrophin deletion reduces edema formation, especially under pathological conditions and during states associated with elevated K+.
Scaffold proteins alpha-syntrophin and dystrophin (show DMD Antibodies) exhibit lower densities in retinal microglia compared with brain astrocytes.
The interaction between the conserved COOH-terminal 125-amino acid domain (which is located in the light chains of MAP1A (show MAP1A Antibodies), MAP1B (show MAP1B Antibodies), and MAP1S (show MAP1S Antibodies)) and alpha1-syntrophin is direct and occurs through the pleckstrin (show PLEK Antibodies) homology domain 2 (PH2 (show PhC2 Antibodies)).
Data show that in Dp71 (show DMD Antibodies)-null mice, the levels of beta-dystroglycan (beta-DG) and alpha1-syntrophin (alpha1-Syn (show SYP Antibodies)) were lower and utrophin (show UTRN Antibodies) expression did not change, and the neuronal nitric oxide synthase (nNOS (show NOS1 Antibodies)) expression and activity were increased.
A novel SNTA1 variant is likely causative for drug induced long-QT syndrome by augmenting the late sodium current.
In a nonreferred nationwide Danish cohort of SIDS (show IDS Antibodies) cases, up to 5/66 (7.5%) of SIDS (show IDS Antibodies) cases can be explained by genetic variants in the sodium channel complex genes.
our results present a possible mechanism of Rac1 activation involving SNTA1 and emphasise its role in ROS (show ROS1 Antibodies) generation, cell migration, and acquisition of malignancy.
Calcium homeostasis mishandling in Duchenne muscular dystrophy (show DMD Antibodies) myotubes depends on store operated calcium entry under the influence alpha1-syntrophin regulation as well as TRPV2 (show TRPV2 Antibodies)-dependant cation influx.
The combined mutations of A261V-SNTA1 plus R800L-SCN5A (show SCN5A Antibodies) increase the INa (show INA Antibodies) current late/peak ratio and time constants of current decay.
In contrast to stomach, lung, colon and rectal cancers, SNTA1 protein was found to be downregulated in esophageal cancers and upregulated in breast cancer.
alpha1D-adrenergic receptors are regulated by syntrophins through a PDZ domain (show INADL Antibodies)-mediated interaction
These results establish an SNTA1-based nNOS (show NOS1 Antibodies) complex attached to SCN5A (show SCN5A Antibodies) as a key regulator of sodium current and suggest that SNTA1 be considered a rare long QT syndrome-susceptibility gene.
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue.
syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)
, 59 kDa dystrophin-associated protein A1 acidic component 1
, acidic alpha 1 syntrophin
, dystrophin-associated protein A1, 59kDa, acidic component
, pro-TGF-alpha cytoplasmic domain-interacting protein 1
, syntrophin, acidic 1
, 59-1 DAP