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Mammalian Monoclonal CASK Primary Antibody for ISt, IHC - ABIN1304568
de Andrade, Kunzelman, Merrill, Fuerst: Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina. in Molecular vision 2014
Show all 17 Pubmed References
Rat (Rattus) Polyclonal CASK Primary Antibody for WB - ABIN1881710
Butz, Okamoto, Südhof: A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. in Cell 1998
Show all 5 Pubmed References
Rat (Rattus) Polyclonal CASK Primary Antibody for WB - ABIN1742324
Sanford, Mays, Rafael-Fortney: CASK and Dlg form a PDZ protein complex at the mammalian neuromuscular junction. in Muscle & nerve 2004
Show all 2 Pubmed References
Data show that Drosophila CASK is associated with both pre and postsynaptic membranes, and that loss of presynaptic CASK leads to less evoked synaptic transmission, fewer spontaneous synaptic events, and reduced synaptic vesicle cycling.
Full-length CASK-beta appears to have a unique role within central circuits that control motor output
Camguk localizes to synaptic regions of the brain and associates in an ATP-regulated manner with CaMKII (show CAMK2 Antibodies) to catalyze formation of a pool of calcium-insensitive CaMKII (show CAMK2 Antibodies).
The results of this study support the involvement of CAKI in neurotransmitter release and nervous system function.
the Drosophila homolog of CASK/Camguk can act as a gain controller on the transition to calcium-independence in vivo.
Dneurexin (DNRX (show NRXN1 Antibodies)) is important for locomotion through a genetic interaction with the scaffold protein (show HOMER1 Antibodies), CAKI/CMG, the Drosophila homolog of vertebrate CASK.
Data suggest that children with heterozygous mutation in the gene CASK kinase (CASK) and mental retardation and microcephaly with pontine and cerebellar hypoplasia (MICPCH) are responsive to intensive therapy aimed at increasing functional skills/independence.
Authors have identified mutations in PAK3, CASK, and MECP2 that likely contribute to intellectual disability, and the findings extend the spectrum of mutations and phenotypes associated with X-linked intellectual disability.
The CASK as a novel regulator of Cav1.2 (show CACNA1C Antibodies) via a modulation of the voltage-gated calcium channel Cav1.2 (show CACNA1C Antibodies) open probability.
findings demonstrate that microcephaly with pontine and cerebellar hypoplasia (MICPCH) is a genetically heterogeneous condition, in which CASK inactivating mutations appear to account for the majority of MICPCH cases and with severer phenotypes, while the non-CASK mutation cases tend to have milder microcephaly
we provide a further characterization of genotype-phenotype correlations in CASK mutations and the presentation of nystagmus and the FGS4 phenotype.
During atrial dilation/remodeling, CASK expression was reduced but its localization remained unchanged.
we report a patient presenting with a complex phenotype consisting of severe, adult-onset, dilated cardiomyopathy, hearing loss and developmental delay, in which exome sequencing revealed two genetic variants that are inherited from a healthy mother: a novel missense variant in the CASK gene, mutations in which cause a spectrum of neurocognitive manifestations
In clinical specimens, CASK was over-expressed in tumors and H. pylori positive tissues, and its mRNA levels were inversely correlated with miR (show MLXIP Antibodies)-203 expression.
Data indicate that patients with low calcium/calmodulin-dependent serine protein kinase (CASK) staining had a significantly better survival compared to patients with high CASK staining.
The findings suggest that CASK and the truncated prestin (show SLC26A5 Antibodies) splice isoform contribute to confinement of prestin (show SLC26A5 Antibodies) to the basolateral region of the plasma membrane.
CASK T740A mutation attenuated the interaction between CASK and TBR1 in the brain. However, CASK T740A mice were generally healthy, without obvious defects in brain morphology. The most dramatic defect among the mutant mice was in extinction of associative memory, though acquisition was normal.
CASK phosphorylates neurexin (show NRXN1 Antibodies), modulating the interaction of liprin (show PPFIA1 Antibodies)-alpha with the CASK-neurexin1beta-Mint1 (show APBA1 Antibodies) complex.
Ths data of this study implies that some phenotypic components of CASK heterozygous deletion mutation associated disorders represent systemic manifestation of metabolic stress.
DLG1 (show DLG1 Antibodies) and CASK play critical cooperative roles in maintaining the nephron progenitor population, potentially via a mechanism involving effects on FGF signaling
Immunofluorescence shows colocalization of Cx43 (show GJA1 Antibodies) and CASK in brain astrocytes.
CASK negatively regulates PMCA4b (show ATP2B4 Antibodies) by directly binding to it and JAM-A (show F11R Antibodies) positively regulates it indirectly through CASK
Data show that CASK expression and the appropriate localization of DLG1 (show DLG1 Antibodies) and LIN7c (show LIN7C Antibodies) are not essential for either epithelial polarity or intestinal homeostasis in vivo.
Post-translational modifications to CASK are major regulatory steps leading to its proteasomal degradation.
CASK is transcribed in mouse testis and processing may play a role in the acquisition of spserm and sperm functions.
findings suggest that Cask plays an important role in all retinal synapses
This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene.
, Calcium/calmodulin-dependent protein kinase
, Camguk/CASK adaptor protein
, calmodulin-dependent kinase
, Peripheral plasma membrane protein CASK
, peripheral plasma membrane protein CASK
, calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase
, protein lin-2 homolog
, trinucleotide repeat containing 8
, G-protein-coupled receptor GPR34