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Human Polyclonal PLDN Primary Antibody for ELISA, WB - ABIN249879
Kouloumenta, Mavroidis, Capetanaki: Proper perinuclear localization of the TRIM-like protein myospryn requires its binding partner desmin. in The Journal of biological chemistry 2007
Show all 2 Pubmed References
Study found that Pldn is present at presynaptic terminals, where it localizes to synaptic microtubules and the cytoskeleton; while pallidin does not have major roles in synaptic growth, structure, or function under basal conditions, pallidin is crucial to maintain the releasable synaptic vesicle pool during conditions of high activity. Stability of Pldn depends crucially on the BLOC-1 subunits dysbindin (show DTNBP1 Antibodies) and blos1 (show BLOC1S1 Antibodies).
PLDN is a direct target of RUNX1 (show RUNX1 Antibodies) and its dysregulation is a mechanism for platelet dense granule deficiency associated with RUNX1 (show RUNX1 Antibodies) haplodeficiency
Mecp2 regulates the expression of components belonging to the dysbindin (show DTNBP1 Antibodies) interactome
no defects i (show BLOC1S4 Antibodies)n the known components of pallidin-muted complex (BLOC-1)have been identif (show MUTED Antibodies)ied in 142 patie (show BLOC1S1 Antibodies)nts with HPS, suggesting that BLOC-1 function may be critical in humans.
Polycystin-2 (show PKD2 Antibodies) requires IFT20 (show IFT20 Antibodies)-GMAP210 (show TRIP11 Antibodies), the exocyst, and BLOC-1 for trafficking from endosomes to primary cilia.
We found 491 proteins sensitive to dysbindin (show DTNBP1 Antibodies) and BLOC-1 loss of function
VAMP7 mediates fusion of BLOC-1-dependent transport carriers with melanosomes, illuminate SNARE recycling from melanosomes as a critical BLOC-3-dependent step.
Data suggest functional links between OCA2 and the BLOC-1, BLOC-2, and AP-3 protein complexes involved in melanosome biogenesis.
The identification of the feeble mutation led to our subsequent observations that AP-3 (show AP3B1 Antibodies), as well as the BLOC-1 and BLOC-2 (show HPS6 Antibodies) are essential for plasmacytoid dendritic cells signaling through TLR7 (show TLR7 Antibodies) and TLR9 (show TLR9 Antibodies).
This study demonstrated that Loss-of-function alleles of BLOC-1, Pldn(pa/pa), and Muted (show MUTED Antibodies)(mu/mu) revealed that this complex acts as a brain-region-specific regulator of AP-3 (show AP3B1 Antibodies).
pallidin may play a role in membrane fusion events required for melanosome biogenesis
BLOC-1, a novel complex containing this and muted (show MUTED Antibodies) proteins involved in the biogenesis of melanosomes and platelet-dense granules
a Cappuccino (show BLOC1S4 Antibodies) frameshift mutation abolishes its ability to interact with pallidin-muted (show MUTED Antibodies) complex (BLOC-1)in mice
The protein encoded by this gene may play a role in intracellular vesicle trafficking. It interacts with Syntaxin 13 which mediates intracellular membrane fusion. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
, BLOC-1 subunit 6
, biogenesis of lysosomal organelles complex-1, subunit 5, pallidin
, biogenesis of lysosome-related organelles complex 1 subunit 6
, pallid protein homolog
, syntaxin 13 binding protein 1
, syntaxin 13-interacting protein pallid
, pallidin homolog
, pallid protein
, syntaxin 13-interacting protein pallidin