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anti-Human CD28 Antibodies:
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Mouse (Murine) Monoclonal CD28 Primary Antibody for BR, CyTox - ABIN1176978
Gelfanov, Lai, Gelfanova, Dong, Su, Liao: Differential requirement of CD28 costimulation for activation of murine CD8+ intestinal intraepithelial lymphocyte subsets and lymph node cells. in Journal of immunology (Baltimore, Md. : 1950) 1995
Show all 14 Pubmed References
Mouse (Murine) Monoclonal CD28 Primary Antibody for BR, CyTox - ABIN2689144
Bluestone: New perspectives of CD28-B7-mediated T cell costimulation. in Immunity 1995
Show all 13 Pubmed References
Mouse (Murine) Monoclonal CD28 Primary Antibody for FACS - ABIN2689149
Wells, Gudmundsdottir, Turka et al.: Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative ... in The Journal of clinical investigation 1998
Show all 13 Pubmed References
Mouse (Murine) Monoclonal CD28 Primary Antibody for Func, FACS - ABIN370901
Gross, Callas, Allison: Identification and distribution of the costimulatory receptor CD28 in the mouse. in Journal of immunology (Baltimore, Md. : 1950) 1992
Show all 16 Pubmed References
Mouse (Murine) Monoclonal CD28 Primary Antibody for Func, ICC - ABIN457400
Albert, Yu, Martin, Anasetti: Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin. in Blood 2005
Show all 10 Pubmed References
Rat (Rattus) Monoclonal CD28 Primary Antibody for Func, FACS - ABIN2749055
Guillonneau, Séveno, Dugast, Li, Renaudin, Haspot, Usal, Veziers, Anegon, Vanhove: Anti-CD28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients. in Journal of immunology (Baltimore, Md. : 1950) 2007
Show all 9 Pubmed References
Rat (Rattus) Monoclonal CD28 Primary Antibody for Func, FACS - ABIN2749056
Kerstan, Armbruster, Leverkus, Hünig: Cyclosporin A abolishes CD28-mediated resistance to CD95-induced apoptosis via superinduction of caspase-3. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 8 Pubmed References
Rat (Rattus) Monoclonal CD28 Primary Antibody for Func, FACS - ABIN611634
van den Brandt, Wang, Reichardt: Resistance of single-positive thymocytes to glucocorticoid-induced apoptosis is mediated by CD28 signaling. in Molecular endocrinology (Baltimore, Md.) 2004
Show all 9 Pubmed References
Human Monoclonal CD28 Primary Antibody for FACS, Func - ABIN349705
Galea-Lauri, Darling, Gan, Krivochtchapov, Kuiper, Gäken, Souberbielle, Farzaneh: Expression of a variant of CD28 on a subpopulation of human NK cells: implications for B7-mediated stimulation of NK cells. in Journal of immunology (Baltimore, Md. : 1950) 1999
Show all 6 Pubmed References
Human Monoclonal CD28 Primary Antibody for FACS, Func - ABIN457388
Jeong, Qiao, Nascimbeni, Hu, Rehermann, Murthy, Liang: Immunization with hepatitis C virus-like particles induces humoral and cellular immune responses in nonhuman primates. in Journal of virology 2004
Show all 6 Pubmed References
These preliminary results suggest that patients undergoing liver or kidney transplant can be stratified at high risk of EAR according to their CD28 molecule expression on peripheral CD4 (show CD4 Antibodies)(+) T lymphocytes.
The aim of this case-control study is to investigate whether GABRG2 (show GABRG2 Antibodies) polymorphisms contribute to susceptibility for Febrile seizure and epilepsy in pooled data of three cohorts, from Malaysia (composed of Malay, Chinese, and Indian), Hong Kong, and Korea.
The rs3116496 (T>C), rs3181098 (G>A) and rs3181100 (G>C) of CD28 were, respectively, found to be correlated with incremental susceptibility to recurrent spontaneous abortion under the allelic model.
Study utilized targeted next-gen (show GEN1 Antibodies) sequencing to identify a novel splicing variation (NM_198903.2:c.1249-1G > T) in the GABRG2 (show GABRG2 Antibodies) gene of a febrile seizure (FS) patient. The potential association of ten selected genetic polymorphisms in IL1RN (show IL1RN Antibodies) (86-bp VNTR), IL10 (show IL10 Antibodies) (rs1900872), PTGS2 (show PTGS2 Antibodies) (8 SNPs, rs689465, rs689466, rs20417, rs13306038, rs201931599, rs689470, rs4648306 and rs4648308) with FS was also examined.
Coexpression of CD200R-CD28 enhances function in WT1 (show CD200R1 Antibodies)-specific T-cell receptor - transduced (show CD8A Antibodies) human primary T cells.
the upregulation of others syncytial molecules, including LAG3 (show LAG3 Antibodies), CTLA4 (show CTLA4 Antibodies), CD28 and CD3 (show CD3 Antibodies), assisting the formation of syncytia with APC (show APC Antibodies) cells.
our data provide the first evidence of a strict link between the absence of CD28 and the expression of perforin (show PRF1 Antibodies), which is likewise enhanced by the expression of NKG2D (show KLRK1 Antibodies), within selected CD4 (show CD4 Antibodies)(+) T cells from cervical cancer patients.
Mutation of the basic clusters in the CD28 cytoplasmic domain reduced the recruitment to the CD28-Lck (show LCK Antibodies) complex of protein kinase (show CDK7 Antibodies) Ctheta; (PKCtheta (show PRKCQ Antibodies);), which serves as a key effector kinase in the CD28 signaling pathway.
This study identified a missense de novo mutation in the GABAA (show GABRg1 Antibodies) receptor gamma2 subunit, P302L, in a patient with Dravet syndrome. The mutation has a novel pathogenic mechanism to cause defects in the conductance and gating of GABAA (show GABRg1 Antibodies) receptors, which results in hyperexcitability and contributes to the pathogenesis of the genetic epilepsy Dravet syndrome.
The mutant CD28 isoforms could accelerate tumor cell growth.
This work unravels a new regulatory mechanism for CD28 signaling that involves dynamic interplay between acidic phospholipids and Ca2 (show CA2 Antibodies)+ to set the local electrostatic environment.
CD28 signaling is required for follicular Treg cell differentiation. Treg-specific deletion of CD28 caused a reduction in TFR (show TFRC Antibodies) cell numbers and function, which resulted in increased germinal center B cells and Ab production. CD28-deficient TFR (show TFRC Antibodies) cells showed a diminished suppressive capacity.
In adoptive therapy of disseminated leukemia, CD200R (show CD200R1 Antibodies)-CD28-transduced leukemia-specific CD8 (show CD8A Antibodies) T cells eradicated otherwise lethal disease more efficiently than wild-type cells and bypassed the requirement for interleukin-2 (show IL2 Antibodies) administration to sustain in vivo activity.
Study shows that CD28 ligation during priming endows T cells with mitochondrial capacity that is important for future T cell responses. We speculate that CD28 temporarily restricts TXNIP (show TXNIP Antibodies) and miR33 expression, and this leads to a transient induction of Cpt1a (show CPT1A Antibodies) and fatty acid oxidation, which are marked by characteristic changes in mitochondria shape and structure.
findings revealed a dual mechanism of monocyte and neutrophil recruitment by T cells relying on overlapping and nonoverlapping roles for the noninducible costimulatory receptor CD28 and the inflammatory cytokine TNF (show TNF Antibodies)
results are consistent with a complex pathway in which CD28 is the primary driver of Treg proliferation and CTLA-4 (show CTLA4 Antibodies) functions as the main brake but is also dependent on TCR signals and interactions with CD80 (show CD80 Antibodies)/CD86 (show CD86 Antibodies).
data suggest that mPEG PV1 (show PLVAP Antibodies)-Fab (show FANCB Antibodies)' acts mainly on IFN-gamma (show IFNG Antibodies)-producing CD4 (show CD4 Antibodies)+ T cells and emphasize that this specific CD28 blockade strategy is a potential specific and alternative tool for the treatment of autoimmune disorders in the eye.
the scaffolding role of RLTPR predominates during CD28 co-stimulation and underpins the similar function of RLTPR in human and mouse T cells.
BAFF (show TNFSF13B Antibodies) upregulates CD28/B7 and CD40 (show CD40 Antibodies)/CD154 (show CD40LG Antibodies) expression, and promotes the interactions between T and B cells in a BAFF-R (show TNFRSF13C Antibodies)-dependent manner
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene.
, T-cell-specific surface glycoprotein CD28
, GABA(A) receptor subunit gamma-2
, GABA(A) receptor, gamma 2
, gamma-aminobutyric acid receptor subunit gamma-2
, CD28 antigen (Tp44)
, T-cell-specific surface glycoprotein CD28 homolog
, T-cell costimulatory molecule CD28
, cell surface protein
, costimulatory molecule B7 receptor CD28
, antigen CD28
, T-cell specific surface glycoprotein CD28
, CD28 precursor protein
, T-cell-specific surface glycoprotein CD28-like protein
, CD28 molecule L homeolog