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anti-Human CD28 Antibodies:
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Mouse (Murine) Monoclonal CD28 Primary Antibody for BR, CyTox - ABIN1176978
Gelfanov, Lai, Gelfanova, Dong, Su, Liao: Differential requirement of CD28 costimulation for activation of murine CD8+ intestinal intraepithelial lymphocyte subsets and lymph node cells. in Journal of immunology (Baltimore, Md. : 1950) 1995
Show all 14 Pubmed References
Mouse (Murine) Monoclonal CD28 Primary Antibody for BR, CyTox - ABIN2689144
Bluestone: New perspectives of CD28-B7-mediated T cell costimulation. in Immunity 1995
Show all 13 Pubmed References
Mouse (Murine) Monoclonal CD28 Primary Antibody for FACS - ABIN2689149
Wells, Gudmundsdottir, Turka et al.: Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative ... in The Journal of clinical investigation 1998
Show all 13 Pubmed References
Mouse (Murine) Monoclonal CD28 Primary Antibody for Func, FACS - ABIN370901
Gross, Callas, Allison: Identification and distribution of the costimulatory receptor CD28 in the mouse. in Journal of immunology (Baltimore, Md. : 1950) 1992
Show all 16 Pubmed References
Mouse (Murine) Monoclonal CD28 Primary Antibody for Func, ICC - ABIN457400
Albert, Yu, Martin, Anasetti: Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin. in Blood 2005
Show all 10 Pubmed References
Rat (Rattus) Monoclonal CD28 Primary Antibody for Func, FACS - ABIN2749055
Guillonneau, Séveno, Dugast, Li, Renaudin, Haspot, Usal, Veziers, Anegon, Vanhove: Anti-CD28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients. in Journal of immunology (Baltimore, Md. : 1950) 2007
Show all 9 Pubmed References
Rat (Rattus) Monoclonal CD28 Primary Antibody for Func, FACS - ABIN2749056
Kerstan, Armbruster, Leverkus, Hünig: Cyclosporin A abolishes CD28-mediated resistance to CD95-induced apoptosis via superinduction of caspase-3. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 8 Pubmed References
Rat (Rattus) Monoclonal CD28 Primary Antibody for Func, FACS - ABIN611634
van den Brandt, Wang, Reichardt: Resistance of single-positive thymocytes to glucocorticoid-induced apoptosis is mediated by CD28 signaling. in Molecular endocrinology (Baltimore, Md.) 2004
Show all 9 Pubmed References
Human Monoclonal CD28 Primary Antibody for FACS, Func - ABIN457388
Galea-Lauri, Darling, Gan, Krivochtchapov, Kuiper, Gäken, Souberbielle, Farzaneh: Expression of a variant of CD28 on a subpopulation of human NK cells: implications for B7-mediated stimulation of NK cells. in Journal of immunology (Baltimore, Md. : 1950) 1999
Show all 6 Pubmed References
Human Monoclonal CD28 Primary Antibody for FACS, Func - ABIN638435
Nunès, Klasen, Ragueneau, Pavon, Couez, Mawas, Bagnasco, Olive: CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events. in International immunology 1993
Show all 7 Pubmed References
The results of this study indicated that the CD28 rs3116496 polymorphism might impact the risk of schizophrenia, especially deficit schizophrenia.
CD28 may be a tumor suppressor gene and rs3116496 polymorphism of CD28 gene showed positively correlation with the increased risk of breast cancer.
percentage of CD4 (show CD4 Antibodies)(+) CD28(null) T-cells was significantly higher in type 1 diabetes patients with and without microvascular complications compared with controls
Suggest that genetic polymorphisms of CD28 function as sex-dependent risk factors for development of acute rejection in an Iranian kidney transplant population.
the expression of CD28 was lower in both Sjogren's syndrome and systemic sclerosis patients
The fraction of CD4 (show CD4 Antibodies)(+)CD28(null) cells proved to be predictive on outcome in congestive heart failure-patients presenting with atrial fibrillation.
In this study we systematically evaluated a series of CAR constructs targeting glypican-3 (GPC3 (show GPC3 Antibodies)), which is selectively expressed on several solid tumors. We compared GPC3 (show GPC3 Antibodies)-specific CARs that encoded CD3zeta (show CD247 Antibodies) (Gz) alone or with costimulatory domains derived from CD28 (G28z), 4-1BB (show TNFRSF9 Antibodies) (GBBz), or CD28 and 4-1BB (show TNFRSF9 Antibodies) (G28BBz).
These preliminary results suggest that patients undergoing liver or kidney transplant can be stratified at high risk of EAR according to their CD28 molecule expression on peripheral CD4 (show CD4 Antibodies)(+) T lymphocytes.
The rs3116496 (T>C), rs3181098 (G>A) and rs3181100 (G>C) of CD28 were, respectively, found to be correlated with incremental susceptibility to recurrent spontaneous abortion under the allelic model.
Coexpression of CD200R-CD28 enhances function in WT1 (show CD200R1 Antibodies)-specific T-cell receptor - transduced (show CD8A Antibodies) human primary T cells.
CD28 may play a role in LPS (show TLR4 Antibodies) nephropathy. Immunofluorescence colocalization analysis revealed a tight association of gammadeltaT cells with B7-1 (show CD80 Antibodies) in the kidney. High B7-1 (show CD80 Antibodies) expression was detected in podocytes treated with LPS (show TLR4 Antibodies).
This work unravels a new regulatory mechanism for CD28 signaling that involves dynamic interplay between acidic phospholipids and Ca2 (show CA2 Antibodies)+ to set the local electrostatic environment.
CD28 signaling is required for follicular Treg cell differentiation. Treg-specific deletion of CD28 caused a reduction in TFR (show TFRC Antibodies) cell numbers and function, which resulted in increased germinal center B cells and Ab production. CD28-deficient TFR (show TFRC Antibodies) cells showed a diminished suppressive capacity.
In adoptive therapy of disseminated leukemia, CD200R (show CD200R1 Antibodies)-CD28-transduced leukemia-specific CD8 (show CD8A Antibodies) T cells eradicated otherwise lethal disease more efficiently than wild-type cells and bypassed the requirement for interleukin-2 (show IL2 Antibodies) administration to sustain in vivo activity.
Mutation of the basic clusters in the CD28 cytoplasmic domain reduced the recruitment to the CD28-Lck (show LCK Antibodies) complex of protein kinase (show CDK7 Antibodies) Ctheta; (PKCtheta (show PRKCQ Antibodies);), which serves as a key effector kinase in the CD28 signaling pathway.
Study shows that CD28 ligation during priming endows T cells with mitochondrial capacity that is important for future T cell responses. We speculate that CD28 temporarily restricts TXNIP (show TXNIP Antibodies) and miR33 expression, and this leads to a transient induction of Cpt1a (show CPT1A Antibodies) and fatty acid oxidation, which are marked by characteristic changes in mitochondria shape and structure.
findings revealed a dual mechanism of monocyte and neutrophil recruitment by T cells relying on overlapping and nonoverlapping roles for the noninducible costimulatory receptor CD28 and the inflammatory cytokine TNF (show TNF Antibodies)
results are consistent with a complex pathway in which CD28 is the primary driver of Treg proliferation and CTLA-4 (show CTLA4 Antibodies) functions as the main brake but is also dependent on TCR signals and interactions with CD80 (show CD80 Antibodies)/CD86 (show CD86 Antibodies).
data suggest that mPEG PV1 (show PLVAP Antibodies)-Fab (show FANCB Antibodies)' acts mainly on IFN-gamma (show IFNG Antibodies)-producing CD4 (show CD4 Antibodies)+ T cells and emphasize that this specific CD28 blockade strategy is a potential specific and alternative tool for the treatment of autoimmune disorders in the eye.
the scaffolding role of RLTPR predominates during CD28 co-stimulation and underpins the similar function of RLTPR in human and mouse T cells.
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, T-cell-specific surface glycoprotein CD28
, CD28 antigen (Tp44)
, T-cell-specific surface glycoprotein CD28 homolog
, T-cell costimulatory molecule CD28
, cell surface protein
, costimulatory molecule B7 receptor CD28
, antigen CD28
, T-cell specific surface glycoprotein CD28
, CD28 precursor protein
, T-cell-specific surface glycoprotein CD28-like protein
, CD28 molecule L homeolog