Browse our VAV1 Proteins (VAV1)

Human Vav 1 Oncogene (VAV1) interaction partners

1. These results support a driver oncogenic role for VAV1 signaling in the pathogenesis of PTCL.

2. no significant association of FoxP3 (show FOXP3 Proteins) promoter rs3761548 or (GT) n repeat length with presumed immunological graft failure. The genotype frequencies of Vav1 intron polymorphisms did not significantly differ between patients with graft failure and matched controls.

3. Data show that GEF (show SLC2A4RG Proteins) Vav1 possesses tumor-suppressor functions in immature T cells.

4. Polymorphisms of VAV1 gene is associated with Rheumatoid arthritis.

5. Vav1 expression is increased in esophageal squamous cell carcinoma, indicates poor prognosis, and can serve as a candidate molecular prognostic marker.

6. TGFbeta (show TGFB1 Proteins) induced the dissociation of DNMT1 (show DNMT1 Proteins) from the VAV1 promoter, leading to demethylation and the subsequent ectopic expression of VAV1 in cancer cells via a SMAD4 (show SMAD4 Proteins)-dependent mechanism

7. Our results suggest the existence of a Vav1/PU.1/miR (show MLXIP Proteins)-142-3p network that supports all-trans retinoic acid -induced differentiation in acute promyelocytic leukemia (show PML Proteins) -derived cells

8. revealed a new function for Vav1 in the negative feedback regulation of the phosphorylation of immunoreceptor tyrosine-based activation motifs within the zeta chains, CD3 delta (show CD3D Proteins), epsilon, gamma chains, as well as activation sites on the critical T cell tyrosine kinases

9. Data indicate that only a single mutation in the proto-oncogene (show RAB1A Proteins) Vav1 enhances tumorigenicity.

10. These findings establish VAV1 as a critical epigenetically regulated oncogene (show RAB1A Proteins) with a key role in MBSHH maintenance, and highlight its potential as a validated therapeutic target and prognostic biomarker for the improved therapy of medulloblastoma.

Mouse (Murine) Vav 1 Oncogene (VAV1) interaction partners

1. this study reveals a novel function of Vav1 in regulating mesenchymal stem cell fate decisions for differentiation through Sirt1 (show SIRT1 Proteins).

2. Data show that GEF (show ARHGEF2 Proteins) Vav1 possesses tumor-suppressor functions in immature T cells.

3. Themis1 acts as a positive regulator of TCR signaling during thymocyte development by promoting Vav1 activity and Grb2 (show GRB2 Proteins) stability

4. Vav1 adaptor has a role in the production of inflammatory cytokines by effector T cells and in the susceptibility to neuroinflammation

5. provide evidence that CD28 (show CD28 Proteins) and the TCR complex regulate NF-kappaB (show NFKB1 Proteins) via different signaling modules of GRB-2 (show GRB2 Proteins)/VAV1 and LAT (show LAT Proteins)/ADAP (show APP Proteins) pathways respectively.

6. Platelet P-Rex and Vav family Rac (show AKT1 Proteins)-GEFs play important proinflammatory roles in leukocyte recruitment.

7. The data show that vav1 not only affects transcription of the MHCII locus but also is an important regulator of MHCII protein transport to the cell surface.

8. analyses revealed a SHP2 (show PTPN11 Proteins)- and Lyn (show LYN Proteins)-dependent pathway leading to phosphorylation of Vav1, Rac (show AKT1 Proteins) activation, and F-actin polymerization in SCF (show KITLG Proteins)-treated BMMCs

9. Data indicate that Vav1 was a key negative regulator of macrophage-derived IL-6 (show IL6 Proteins) production.

10. Bruton's Tyrosine Kinase (BTK (show BTK Proteins)) and Vav1 contribute to Dectin1 (show CLEC7A Proteins)-dependent phagocytosis of Candida albicans in macrophages.