Browse our ZAP70 Proteins (ZAP70)

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

• zeta chain of T cell receptor associated protein kinase 70kDa L homeolog (zap70.L)
• zeta chain of T cell receptor associated protein kinase 70kDa (zap70)
• zeta chain of T cell receptor associated protein kinase 70 (ZAP70)
• tyrosine-protein kinase ZAP-70 (LOC707555)
• putative tyrosine-protein kinase zap-70 (Smp_149470)
• Show all gene names
• tyrosine-protein kinase ZAP-70 (LOC100342021)
• tyrosine-protein kinase ZAP-70 (LOC100390922)
• zeta-chain (TCR) associated protein kinase 70kDa (ZAP70)
• tyrosine-protein kinase ZAP-70 (LOC100542877)
• zeta-chain (TCR) associated protein kinase (Zap70)
• zeta chain of T cell receptor associated protein kinase 70 (Zap70)
• zeta chain of T-cell receptor associated protein kinase 70 (ZAP70)
• tyrosine-protein kinase ZAP-70 (ZAP70)
• zeta-chain (TCR) associated protein kinase 70kDa (Zap70)

• 70kDa protein
• AI327364 protein
• MGC80670 protein
• MGC88962 protein
• mrtle protein
• Show all synonym aliases
• mur protein
• SRK protein
• STCD protein
• STD protein
• TZK protein
• ZAP-70 protein
• ZAP70 protein

zeta-chain (TCR) associated protein kinase 70kDa , zeta-chain associated protein kinase 70kDa , tyrosine-protein kinase zap-70 , tyrosine-protein kinase ZAP-70-like , 70 kDa zeta-associated protein , 70 kDa zeta-chain associated protein , syk-related tyrosine kinase , tyrosine-protein kinase ZAP-70 , syk-related protein tyrosine kinase , zeta-chain associated protein kinase, 70kD