Browse our ZAP70 Proteins (ZAP70)

Full name:: zeta-Chain (TCR) Associated Protein Kinase 70kDa Proteins (ZAP70)

On www.antibodies-online.com are 11 zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) Proteins from 6 different suppliers available. Additionally we are shipping ZAP70 Antibodies (646) and ZAP70 Kits (19) and many more products for this protein. A total of 692 ZAP70 products are currently listed.

Synonyms:: 70kDa, AI327364, MGC80670, MGC88962, mrtle, mur, Srk, STCD, STD, TZK, ZAP-70, ZAP70, zgc:110383

list all proteins	Gene Name	GeneID	UniProt
	ZAP70	7535	P43403
Mouse ZAP70	ZAP70	22637	P43404
Rat ZAP70	ZAP70	301348
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ZAP70 Proteins (ZAP70) by Origin

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Relevant Pathways for ZAP70 Proteins

TCR Signaling

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Human zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) interaction partners

ZAP-70 was a strong prognostic biomarker for patients with CLL
In this article, the authors have shown that Natural killer cells can reduce their functional role through downregulation of Syk (show SYK Proteins) and Zap70 kinases.
These results identify a tight negative feedback loop in which ZAP-70-activated p38 (show CRK Proteins) reciprocally phosphorylates ZAP-70 and destabilizes the signaling complex.
we have identified a new redox-active motif which is crucial for the regulation of Zap70 stability/activity. We believe that this motif has the potential to become a novel target for the development of therapeutic tools to modulate the expression/activity of kinases.
The expression of COBLL1, LPL, and ZAP70 corresponded to patient prognosis and to IGHV mutational status, although not absolutely. When we combined all three markers together and performed the ROC analysis, AUC increased compared to the AUC of individual gene expression.
The authors find that ZAP-70 selects its substrates by utilizing an electrostatic mechanism that excludes substrates with positively-charged residues and favors LAT (show ORC3 Proteins) and SLP-76 (show LCP2 Proteins) phosphosites that are surrounded by negatively-charged residues.
The data describe the critical early step of directional cell movement toward SDF-1 (show CXCL12 Proteins) that ZAP-70 is recruited to the CXCR4 (show CXCR4 Proteins) at the leading edge of membrane and consequently modulates lamellipodia/filopodia formation and integrin activation.
The study identified the criteria for the design of binders that specifically address either the Syk (show SYK Proteins) or the Zap-70 Tandem Src (show SRC Proteins) Homology 2 Domains, tSH2. While Syk (show SYK Proteins) tSH2 has a rather broad substrate scope, ZAP-70 tSH2 required a proximal arrangement of the phosphotyrosine ligands in defined strand orientation.
ZAP-70 signaling was impaired by cholesterol depletion, further supporting the importance of membrane organization in TCR signaling.
We conclude that ZAP70 plays a role for the homing to and/or the survival of ALL cells in the CNS and that ZAP70 may represent a therapeutic target. Furthermore, targeting CCR7 (show CCR7 Proteins)/CXCR4 (show CXCR4 Proteins) may be particularly promising in treating T-ALL.

Mouse (Murine) zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) interaction partners

RanBP2 expression was regulated by Zap70.
disruption of normal Zap70 autoinhibition engaged negative feedback mechanisms by which negative selection and inhibitory receptors restrain TCR signaling to enforce both central and peripheral tolerance.
in this study, authors discovered a cycle of recruitment, activation and release for Zap70 kinases at phosphorylated T-cell antigen receptors, which turned them into a 'catalytic unit' that amplified antigenic stimuli
was significantly increased in 22-month AEW mice compared with 5-month AEW mice. ELISA data showed that secretions of IL-2 (show IL2 Proteins) and NGF (show NGFB Proteins) in 22-month AEW mice were higher than 5-month AEW mice. Our results indicate that increased ZAP70 is involved in dry skin in elderly pruritus. Increased secretion of IL-2 (show IL2 Proteins) and NGF (show NGFB Proteins) may induce dry skin itch.
this study shows that ZAP-70 mutation has a strong impact on T cell-driven arthritis in SKG model regardless of the genetic background
These findings establish Otud7b (show OTUD7B Proteins) as a positive regulator of T cell receptor-proximal signaling and T cell activation, highlighting the importance of deubiquitination in regulating Zap70 function.
Data suggest that ring finger protein 41 Nrdp1 (show RNF41 Proteins) terminates T cell antigen receptors (TCRs) signaling by inactivating Zap70 kinase.
Zap70 as a structural protein regulates integrin-mediated control of actin and with its catalytic activity regulates T cell receptor-mediated control of actin and membrane remodelling during formation of the immunological synapse.
Blockade of CXCR7 (show CXCR7 Proteins) suppressed MIF (show MIF Proteins)-mediated ERK (show EPHB2 Proteins)- and zeta-chain-associated protein kinase (show CDK7 Proteins) (ZAP)-70 activation
mediates the CD4 (show CD4 Proteins) lineage differentiation in response to Class II selecting ligands

Cow (Bovine) zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) interaction partners

The surface expression of CTLA-4 (show CTLA4 Proteins) was increased in subclinical stages of paratuberculosis infection while levels of ZAP-70 were decreased in CD4 (show CD4 Proteins)+ T cells of both subclinical and clinical animals, indicating a change in T cell phenotype with disease state.

Zebrafish zeta-Chain (TCR) Associated Protein Kinase 70kDa (ZAP70) interaction partners

syk (show SYK Proteins) and zap-70 function redundantly in an early progenitor to promote the migration of intersegmental vessel angioblasts and lymphangioblasts that contribute to the thoracic duct, either downstream of, or in parallel to vegfa (show VEGFA Proteins).

ZAP70 Protein Profile

Protein Summary

This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Alternative names and synonyms associated with ZAP70

zeta chain of T-cell receptor associated protein kinase 70 (ZAP70)
putative tyrosine-protein kinase zap-70 (Smp_149470)
zeta-chain (TCR) associated protein kinase (Zap70)
zeta chain of T cell receptor associated protein kinase 70 (Zap70)
zeta-chain (TCR) associated protein kinase 70kDa (ZAP70)
zeta chain of T cell receptor associated protein kinase 70kDa L homeolog (zap70.L)
zeta chain of T cell receptor associated protein kinase 70kDa (zap70)
zeta chain of T cell receptor associated protein kinase 70 (ZAP70)
tyrosine-protein kinase ZAP-70 (LOC707555)
tyrosine-protein kinase ZAP-70 (ZAP70)
tyrosine-protein kinase ZAP-70 (LOC100342021)
tyrosine-protein kinase ZAP-70 (LOC100390922)
tyrosine-protein kinase ZAP-70 (LOC100542877)
zeta-chain (TCR) associated protein kinase 70kDa (Zap70)
zeta-chain (TCR) associated protein kinase (zap70)

70kDa protein
AI327364 protein
MGC80670 protein
MGC88962 protein
mrtle protein
mur protein
Srk protein
STCD protein
STD protein
TZK protein
ZAP-70 protein
ZAP70 protein
zgc:110383 protein

Protein level used designations for ZAP70

70 kDa zeta-associated protein , 70 kDa zeta-chain associated protein , syk-related tyrosine kinase , tyrosine-protein kinase ZAP-70 , zeta-chain associated protein kinase, 70kD , tyrosine-protein kinase zap-70 , syk-related protein tyrosine kinase , zeta-chain (TCR) associated protein kinase 70kDa , zeta-chain associated protein kinase 70kDa , tyrosine-protein kinase ZAP-70-like

GENE ID	SPECIES
7535	Homo sapiens
8343736	Schistosoma mansoni
22637	Mus musculus
301348	Rattus norvegicus
420086	Gallus gallus
446840	Xenopus laevis
448557	Xenopus (Silurana) tropicalis
459427	Pan troglodytes
504509	Bos taurus
707555	Macaca mulatta
100271860	Canis lupus familiaris
100342021	Oryctolagus cuniculus
100390922	Callithrix jacchus
100451782	Pongo abelii
100524930	Sus scrofa
100542877	Meleagris gallopavo
100589243	Nomascus leucogenys
100713473	Cavia porcellus
553615	Danio rerio

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