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This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
zeta-chain (TCR) associated protein kinase 70kDa
, zeta-chain associated protein kinase 70kDa
, tyrosine-protein kinase zap-70
, tyrosine-protein kinase ZAP-70-like
, 70 kDa zeta-associated protein
, 70 kDa zeta-chain associated protein
, syk-related tyrosine kinase
, tyrosine-protein kinase ZAP-70
, syk-related protein tyrosine kinase
, zeta-chain associated protein kinase, 70kD