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anti-Mouse (Murine) DNA2 Antibodies:
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The authors establish that a second Dna2-Rpa interaction is mutually exclusive with Rpa-DNA interactions and mediates the displacement of Rpa from ssDNA.
DNA2 helicase cleaves G-quadruplex DNA and is required for telomere integrity.DNA2 reduces replication stress at telomeres, thereby preserving genome stability and suppressing cancer development.
Characterization of the endonuclease and ATP-dependent flap (show ALOX5AP Antibodies) endo/exonuclease (show EXO1 Antibodies) of Dna2.
This review mainly encompasses the key functions of DNA2 in human cells with various aspects, especially focusing on the genome integrity, and also generalizes the recent insights to the mechanisms related to the occurrence of cancer and other diseases potentially linked to the mutations in DNA2.
The authors show that the helicase of hDNA2 functionally integrates with BLM or WRN helicases to promote double-stranded DNA degradation by forming a heterodimeric molecular machine. This collectively suggests that the human DNA2 motor promotes the enzyme's capacity to degrade double-stranded DNA in conjunction with BLM or WRN and thus promote the repair of broken DNA.
the motor of DNA2 functions as a ssDNA translocase to promote degradation of 5'-terminated DNA.
The suppression of FANCD2 (show FANCD2 Antibodies)(-/-) by DNA2 knockdowns suggests that DNA2 and FANCD2 (show FANCD2 Antibodies) also have antagonistic roles: in the absence of FANCD2 (show FANCD2 Antibodies), DNA2 somehow corrupts repair.
BRCA1 and CtIP (show RBBP8 Antibodies) contribute to DSB resection by recruiting Dna2 to damage sites, thus ensuring the robust DSB resection necessary for efficient homologous recombination.
depletion of DNA2 in cells reduces proliferation, addition of estrogen restores proliferation. cells responding to estrogen will proliferate despite impaired in DNA2 activity, potentially promoting genomic instability and triggering cancer development.
EXO1 (show EXO1 Antibodies), MRE11 (show MRE11A Antibodies), and CtIP (show RBBP8 Antibodies) are not involved in the same mechanism of reversed fork processing, whereas human RECQ1 (show RECQL Antibodies) limits DNA2 activity by preventing extensive nascent strand degradation.
DNA2 stimulates the helicase activity of BLM (show BLM Antibodies).
WRN (show RECQL2 Antibodies) and BLM (show BLM Antibodies) act epistatically with DNA2 to promote the long-range resection of double strand break ends in human cells.
DNA2 interacts with FANCD2 (show FANCD2 Antibodies), and cisplatin induces FANCD2 (show FANCD2 Antibodies) ubiquitylation even in the absence of DNA2.
Data show that cleavage of free 5' DNA ends at clean double-strand breaks (DSBs) is mediated by DNA replication helicase/nuclease (show DCLRE1C Antibodies) 2 (Dna2).
Dna2 co-localizes in foci with RPA (show RPA1 Antibodies) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 Antibodies). Dna2 interacts with the DSB repair and checkpoint proteins Nbs1 (show NLRP2 Antibodies) and ATM (show ATM Antibodies).
Results provide strong evidence that xDNA2 is a major nuclease (show DCLRE1C Antibodies) for the resection of DNA ends for homology-dependent DNA double-strand break repair in eukaryotes.
DNA2 is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability (Duxin et al., 2009
DNA replication ATP-dependent helicase-like homolog
, DNA replication ATP-dependent helicase/nuclease DNA2
, DNA2-like helicase
, DNA replication helicase 2 homolog