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DNA2 antibody (AA 1-300)

DNA2 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7150306
  • Target See all DNA2 Antibodies
    DNA2 (DNA Replication Helicase 2 Homolog (DNA2))
    Binding Specificity
    • 4
    • 1
    • 1
    AA 1-300
    Reactivity
    • 19
    • 12
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 19
    Rabbit
    Clonality
    • 19
    Polyclonal
    Conjugate
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DNA2 antibody is un-conjugated
    Application
    • 9
    • 7
    • 5
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human DNA replication ATP-dependent helicase/nuclease DNA2 protein (1-300AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    DNA2 (DNA Replication Helicase 2 Homolog (DNA2))
    Alternative Name
    DNA2 (DNA2 Products)
    Synonyms
    DNA2L antibody, Dna2l antibody, E130315B21Rik antibody, PEOA6 antibody, hDNA2 antibody, XDna2 antibody, dna2-A antibody, DNA replication helicase/nuclease 2 antibody, DNA replication helicase/nuclease 2 S homeolog antibody, DNA2 antibody, Dna2 antibody, dna2.S antibody
    Background

    Background: Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5\'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5\'-ssDNA, while the 3\'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5\'-3\' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5\'-3\' DNA helicase activity is subject to debate. According to various reports, the helicase activity is weak and its function remains largely unclear. Helicase activity may promote the motion of DNA2 on the flap, helping the nuclease function.

    Aliases: DNA replication ATP-dependent helicase-like homolog antibody, DNA replication helicase 2 homolog antibody, DNA replication helicase 2, yeast, homolog of antibody, DNA replication helicase 2-like antibody, DNA replication helicase/nuclease 2 antibody, DNA2 antibody, DNA2-like helicase antibody, DNA2L antibody, DNA2L_HUMAN antibody, HDNA2 antibody, KIAA0083 antibody, PEOA6 antibody, SCKL8 antibody

    UniProt
    P51530
    Pathways
    Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA
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