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anti-Mouse (Murine) Antibodies:
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NASP (show NASP Antibodies) balances the activity of the heat shock proteins Hsc70 (show HSPA8 Antibodies) and Hsp90 (show HSP90 Antibodies) to direct H3-H4 for degradation by chaperone-mediated autophagy
H2B and H4 histones were mobilized during herpes simplex virus 1 infection and became available to bind to viral genomes.
assessed the functional coupling between chromatin organization and regulation of histone H4/n gene expression during HL-60 differentiation into the monocyte/macrophage lineage
deiminated residues were present in H2A (1 (show HIST1H2AE Antibodies)-56) and H4 (1-52)
Loss of the H4 arginine 3 methylation mark through short hairpin RNA-mediated knockdown of PRMT5 (show PRMT5 Antibodies) leads to reduced DNMT3A (show DNMT3A Antibodies) binding, loss of DNA methylation (show HELLS Antibodies) and gene activation.
Results show that deregulation of histone H4 results in catastrophic cellular and molecular defects that lead to genomic instability.
The in vivo co-expression of Hinfp and histone H4 genes is consistent with the biological function of Hinfp as a principal transcriptional regulator of histone H4 gene expression during mouse development.
Data indicate that the CDK2 (show CDK2 Antibodies)/cyclin E (show CCNE1 Antibodies)/p220(NPAT (show NPAT Antibodies))/HINFP (show HINFP Antibodies)/histone gene signaling pathway at the G1/S phase transition is an essential, nonredundant cell cycle regulatory mechanism that is established early in embryogenesis.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails\; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated\; this record represents the centromeric copy.
H4 histone family, member N
, H4 histone, family 2
, histone 2, H4a
, histone H4
, histone IV, family 2
, histone 2, H4