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Human LIG1 Protein expressed in HEK-293 Cells - ABIN2719545
Liu, Lu, Ali, Liu, Zheng, Dai, Li, Xu, Hua, Zhou, Ortega, Li, Kunkel, Shen: Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex. in The EMBO journal 2015
The AtLIG1 is an important component of the active DNA demethylation machinery.
LIG1 is required for both single-nucleotide or long-patch base excision repair.
In the study, we show that loss-of-function of the major DNA LIGASE I (AtLIG1) in Arabidopsis thaliana causes maternal effects in the endosperm, which is the seed tissue that nurtures embryo development.
Nuclear or mitochondrial targeting of LIG1 is accomplished through an evolutionarily conserved translation initiation mechanism. [AtLIG1]
DNA ligase 1 functions in both DNA replication and in repair of both ss and dsDNA strand breaks.
single-stranded break repair by human DNA ligase III isoforms reveal biochemical differences from DNA ligase
A histone H3K9-like mimic within LIG1 is methylated by G9a and GLP and avidly binds UHRF1. Interaction with methylated LIG1 promotes the recruitment of UHRF1 to DNA replication sites and is required for DNA methylation maintenance.
The rs156641 polymorphism of DNA ligase 1 (LIG1) was significantly associated with lung cancer risk, whereas no association was found between rs3730931/rs439132/rs20579 polymorphisms and lung cancer.
Data suggest that DNA ligase I (LigI)-deficient 46BR.1G1 cells represent a model to investigate the biological effects of sub-lethal levels of DNA insults.
The LIG1 CC genotype was associated with susceptibility to non-small cell lung cancer, and the AA genotype demonstrated increased radiosensitivity compared to the AC and CC genotypes.
A novel method for monitoring functional lesion-specific recruitment of repair proteins in live cells.
Ppolymorphisms in LIG1 affect its expression and may therefore change its function.
there is no association between LIGI polymorphisms and cervical cancer risk. However, they may be playing an important role in modulating the risk of cervical adenocarcinoma in North Indian women
DNA ligase I also interacts with replication factor C, the factor that loads the PCNA trimeric ring onto DNA.
Data indicate that Ku70/Ku80 facilitates the cooperative binding of multiple XRCC4/Ligase IV (XL) and XLF molecules to DNA.
Single nucleotide polymorphisms in LIG1 are associated with myelodysplastic syndromes.
phosphorylation of serine 51 on hLigI plays a critical role in regulating the interaction between hLigI and RFC, which is required for efficient DNA replication and repair.
Data show that association of study-wide significance (P < 8.2 x 10(-5)) was identified for single-nucleotide polymorphisms (SNP) in TP53, LIG1, and BIK.
Kinetic mechanism of human DNA ligase I reveals magnesium-dependent changes in the rate-limiting step that compromise ligation efficiency.
RNA silencing of human DNA ligase I expression severely reduced replication of viral DNA in cells infected with vaccinia virus ligase-deficient mutants.
DNA ligase I competes with FEN1 to expand repetitive DNA sequences in vitro.
stimulated by APE1 for progression through the base excision repair pathway
phosphorylation of DNA ligase I and possibly other replicative enzymes is part of the mechanism that directs the disassembly of the replication machinery at the completion of S-phase.
majority of single-strand DNA interruptions produced during the repair of alkylated DNA bases are repaired by the pathway mediated by Pol beta and either Lig I or Lig III
crystal structure of human DNA ligase I (residues 233 to 919) in complex with a nicked, 5' adenylated DNA intermediate
Increased presynaptic glutamate release is a key early event resulting from Lgi1-deficiency, which likely contributes to epileptogenesis.
Lig1 is not absolutely required for cellular DNA replication and repair in Lig1-null cell line.
LigI has a highly specific role in CTG repeat maintenance in the maternal germline, involved in mediating CTG expansions and in the avoidance of maternal CTG contractions.
DNA ligase I null mouse cells show normal DNA repair activity but altered DNA replication and reduced genome stability.
LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.
DNA ligase 1
, polydeoxyribonucleotide synthase [ATP] 1
, DNA ligase (ATP) 1
, DNA ligase I
, LIG1, ligase I, DNA, ATP-dependent