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The present findings indicate that WRAP53beta and RNF8 (show RNF8 Proteins) are rate-limiting factors in the repair of DNA double-strand breaks and raise the possibility that upregulation of WRAP53beta may contribute to genomic stability in and survival of cancer cells.
WDR79 colocalized and interacted with USP7 (show USP7 Proteins) in the nucleus of non-small cell lung cancer cells. This event, in turn, reduced the ubiquitination of Mdm2 (show MDM2 Proteins) and p53 (show TP53 Proteins), thereby increasing the stability and extending the half-life of the two proteins.
The depletion of WRAP53 inhibits the proliferation of lung-adenocarcinoma A549 and SPC (show UCN3 Proteins)-A-1 cells via G1/S cell-cycle arrest. Several proteins interacting with WRAP53 were identified through co-immunoprecipitation and liquid chromatography/mass spectrometry.
we analyzed the association between the WRAP53 gene rs2287499 C>G polymorphism and risk of cancer using five case-control studies.In the overall analysis, no significant association between rs2287499 and risk of cancer was found.
The interaction of MDC1 with RNF8 (show RNF8 Proteins), but not with ATM (show ATM Proteins) requires WRAP53beta, suggesting that WRAP53beta facilitates the former interaction without altering phosphorylation of MDC1 by ATM (show ATM Proteins).
the sub-cellular localization of the WRAP53 protein has a significant impact on breast cancer survival.
This study showed that UCA1 and WRAP53 upregulation may serve as novel serum biomarkers for hepatocellular carcinoma diagnosis and prognosis.
WRAP53 is associated with development and progression of esophageal squamous cell carcinoma
Decreasing the expression of WRAP53 using RNA interference technique can enhance the radiosensitivity.
The telomerase holoenzyme Cajal body-associated protein, TCAB1, was released from telomerase RNA in mitotic cells coincident with TCAB1 delocalization from Cajal bodies.
Overexpression of WDR79 in non-small cell lung cancer is linked to tumor progression.
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene.
WD repeat-containing protein 79
, WD40 protein Wrap53
, WD40 repeat-containing protein encoding RNA antisense to p53
, telomerase Cajal body protein 1
, WD repeat domain 79
, WD40 repeat-containing protein encoded by RNA antisense to p53
, WD repeat containing, antisense to TP53