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The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses.
, prostaglandin D2 receptor
, prostaglandin D receptor
, prostaglandin D2 receptor-like
, PGD receptor
, Prostanoid DP receptor
, prostaglandin D2 receptor (DP)
, prostanoid DP receptor