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A role for PGD2 (show PTGDS Proteins) signals acting through PTGDR in suppression of intestinal tumors.
Data indicate a PLA2G3 (show PLA2G3 Proteins)-lipocalin (show APOD Proteins)-type PGD2 synthase (L-PGDS)-PGD2 (show PTGDS Proteins) receptor DP1 loop that drives mast cell maturation.
PGD(2)-DP signaling reduces vascular permeability both in vivo.
platelet DP1 (show REEP5 Proteins) is not present in mice. Despite this, DP1 (show REEP5 Proteins) deletion in mice augmented aneurysm formation and the hypertensive response to Ang II (show AGT Proteins) and accelerated atherogenesis and thrombogenesis.
The present study demonstrates that functional roles of PGD2 and its receptors appear to depend on the nature of the inflammation in chronic skin inflammation, chronic contact hypersensitivity and IgE-mediated chronic allergic skin inflammation
After epicutaneous sensitization with ovalbumin (show OVA Proteins) (OVA), DP activation inhibits the migration of Langerhans cells (LC)s and affects the priming of antigen-specific T cells in the draining lymph nodes.
pain sensitivity was increased in prostaglandin D receptor mutant mice
Polymorphisms of prostaglandin D receptor (PTGDR) gene influence basal promoter activity and gene expression, as well as the cytokine secretory pattern.
An association was found between single nucleotide polymorphisms of the PTGFR and SLCO2A1 genes and the response to latanoprost in Han Chinese patients with glaucoma. These SNPs may be important determinants of differential response to latanoprost.
EP2 (show SPAG11B Proteins) receptors seem to be able to distinguish endogenous ligands PGD2 (show PTGDS Proteins), PGE2 or prostaglandin F2alpha better than DP receptors.
PGD2 (show PTGDS Proteins) markedly augments disease activity through its ability to enhance the proinflammatory actions of macrophages and subsequent neutrophil activation.
Non-obligatory role of prostaglandin D2 receptor subtype 1 in rosacea: laropiprant in comparison to a placebo did not alleviate the symptoms of erythematoelangiectaic rosacea
EP2 (show SPAG11B Proteins) receptors exhibit more constraints to mutations than DP receptors.
Low DP1 prostanoid receptor is associated with gastric cancer progression.
Lipocalin (show APOD Proteins)-type prostaglandin D2 (PGD2) synthase (L-PGDS) interacts intracellularly with the G protein-coupled receptor (show ADRA1A Proteins) DP1 in an agonist-independent manner.
the PTGDR -549 C/T polymorphism confers susceptibility to asthma in Europeans and adults. However, no association was found between the PTGDR 441 C/T and -197 C/T polymorphisms or the CCC and TCT (show TRPM7 Proteins) haplotypes and asthma susceptibility.
PGD(2)-DP signaling reduces vascular permeability via endothelial cAMP/PKA/Tiam1/Rac1 pathway.
The protein encoded by this gene is a G-protein-coupled receptor. It has been shown to function as a prostanoid DP receptor. The activity of this receptor is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses.
prostaglandin D2 receptor (DP)
, prostaglandin D2 receptor
, PGD receptor
, PGD2 receptor
, prostanoid DP receptor
, prostaglandin D receptor
, prostaglandin D2 receptor-like
, Prostanoid DP receptor