Browse our Prostaglandin D2 Receptor (DP) Proteins (PTGDR)

Human Prostaglandin D2 Receptor (DP) (PTGDR) interaction partners

1. PGD2 (show PTGDS Proteins) signaling through the D-prostanoid receptor 1 (DP1) receptor is necessary for optimal microglia/macrophage activation and IFN expression after infection with a neurotropic coronavirus

2. Polymorphisms of prostaglandin D receptor (PTGDR) gene influence basal promoter activity and gene expression, as well as the cytokine secretory pattern.

3. An association was found between single nucleotide polymorphisms of the PTGFR and SLCO2A1 genes and the response to latanoprost in Han Chinese patients with glaucoma. These SNPs may be important determinants of differential response to latanoprost.

4. EP2 (show SPAG11B Proteins) receptors seem to be able to distinguish endogenous ligands PGD2 (show PTGDS Proteins), PGE2 or prostaglandin F2alpha better than DP receptors.

5. PGD2 (show PTGDS Proteins) markedly augments disease activity through its ability to enhance the proinflammatory actions of macrophages and subsequent neutrophil activation.

6. Non-obligatory role of prostaglandin D2 receptor subtype 1 in rosacea: laropiprant in comparison to a placebo did not alleviate the symptoms of erythematoelangiectaic rosacea

7. EP2 (show SPAG11B Proteins) receptors exhibit more constraints to mutations than DP receptors.

8. Low DP1 prostanoid receptor is associated with gastric cancer progression.

9. Lipocalin (show APOD Proteins)-type prostaglandin D2 (PGD2) synthase (L-PGDS) interacts intracellularly with the G protein-coupled receptor (show ADRA1A Proteins) DP1 in an agonist-independent manner.

10. the PTGDR -549 C/T polymorphism confers susceptibility to asthma in Europeans and adults. However, no association was found between the PTGDR 441 C/T and -197 C/T polymorphisms or the CCC and TCT (show TRPM7 Proteins) haplotypes and asthma susceptibility.

Mouse (Murine) Prostaglandin D2 Receptor (DP) (PTGDR) interaction partners

1. PGD2 (show PTGDS Proteins) signaling through the D-prostanoid receptor 1 (DP1 (show REEP5 Proteins)) receptor is necessary for optimal microglia/macrophage activation and IFN expression after infection with a neurotropic coronavirus

2. A role for PGD2 (show PTGDS Proteins) signals acting through PTGDR in suppression of intestinal tumors.

3. Data indicate a PLA2G3 (show PLA2G3 Proteins)-lipocalin (show APOD Proteins)-type PGD2 synthase (L-PGDS)-PGD2 (show PTGDS Proteins) receptor DP1 loop that drives mast cell maturation.

4. platelet DP1 (show REEP5 Proteins) is not present in mice. Despite this, DP1 (show REEP5 Proteins) deletion in mice augmented aneurysm formation and the hypertensive response to Ang II (show AGT Proteins) and accelerated atherogenesis and thrombogenesis.

5. The present study demonstrates that functional roles of PGD2 and its receptors appear to depend on the nature of the inflammation in chronic skin inflammation, chronic contact hypersensitivity and IgE-mediated chronic allergic skin inflammation

6. After epicutaneous sensitization with ovalbumin (show OVA Proteins) (OVA), DP activation inhibits the migration of Langerhans cells (LC)s and affects the priming of antigen-specific T cells in the draining lymph nodes.

7. pain sensitivity was increased in prostaglandin D receptor mutant mice