PTGDR Protein (AA 1-357) (His tag)

Catalog No. ABIN7556681

This Recombinant PTGDR protein is expressed in HEK-293 Cells.

Quick Overview for PTGDR Protein (AA 1-357) (His tag) (ABIN7556681)

Target: PTGDR (Prostaglandin D2 Receptor (PTGDR))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purity: > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)

Grade: custom-made

Product Details

Protein Characteristics: AA 1-357

Purification tag / Conjugate: This PTGDR protein is labelled with His tag.

Purpose: Predefined custom protein recombinant Ptgdr Protein expressed in mammalian cells.

Sequence: MNESYRCQTS TWVERGSSAT MGAVLFGAGL LGNLLALVLL ARSGLGSCRP GPLHPPPSVF YVLVCGLTVT DLLGKCLISP MVLAAYAQNQ SLKELLPASG NQLCETFAFL MSFFGLASTL QLLAMAVECW LSLGHPFFYQ RHVTLRRGVL VAPVVAAFCL AFCALPFAGF GKFVQYCPGT WCFIQMIHKE RSFSVIGFSV LYSSLMALLV LATVVCNLGA MYNLYDMHRR QRHYPHRCSR DRAQSGSDYR HGSLHPLEEL DHFVLLALMT VLFTMCSLPL IYRAYYGAFK LENKAEGDSE DLQALRFLSV ISIVDPWIFI IFRTSVFRML FHKVFTRPLI YRNWSSHSQQ SNVESTL Sequence without tag. The proposed Strep-Tag is based on experience with the expression system. Our team may suggest an additional tag depending on the complexity of the protein. If you have a special request, please contact us.

Specificity: If you are looking for a specific domain and are interested in a partial protein or a different isoform, please contact us regarding an individual offer.

Characteristics: Key Benefits:

• Predefined custom protein - from design to production - by highly experienced protein experts.
• Protein expressed in mammalian cells and purified in one-step affinity chromatography
• The optimized expression system ensures reliability for intracellular, secreted and transmembrane proteins.
• State-of-the-art algorithm used for plasmid design (Gene synthesis).

This protein is a predefined protein and will be made for the first time for your order. Our experts in the lab try to ensure that you receive soluble protein.

If you are not interested in a full length protein, please contact us for individual protein fragments.

The big advantage of ordering our predefined custom proteins in comparison to ordering custom-made proteins from other companies is that there is no financial obligation in case the protein cannot be expressed or purified.

Application Details

Application Notes: We expect the protein to work for functional studies. As the protein has not been tested for functional studies yet we cannot offer a guarantee though.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The buffer composition is at the discretion of the manufacturer.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -80 °C

Storage Comment: Store at -80°C.

Expiry Date: 12 months

Target Details

Target: PTGDR (Prostaglandin D2 Receptor (PTGDR))

Alternative Name: Ptgdr

Background: Prostaglandin D2 receptor (PGD receptor) (PGD2 receptor) (Prostanoid DP receptor),FUNCTION: Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (PubMed:23624557). {ECO:0000250|UniProtKB:Q9R261, ECO:0000269|PubMed:23624557}.

Molecular Weight: 40.0 kDa

UniProt: P70263

AlphaFold: P70263

Pathways: Thromboxane A2 Receptor Signaling