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ATF4 (show ATF4 Proteins) and ATF6beta act synergistically in the negative regulation of placental growth factor (show PGF Proteins) mRNA expression
unglycosylated ATF6beta may directly facilitate the expression of ERSR genes by losing its repressor function to ATF6alpha (show ATF6 Proteins)
Toxoplasma virulence factor ROP18 inactivates host innate and adaptive immune responses by targeting ATF6beta.
interference with ATF6beta-dependent immune responses is a novel pathogenic mechanism induced by ROP18
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum\; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.
cAMP responsive element binding protein-like 1
, activating transcription factor 6 beta
, cyclic AMP-dependent transcription factor ATF-6 beta
, cyclic AMP-dependent transcription factor ATF-6 beta-like
, Creb-related protein
, cAMP response element-binding protein-related protein
, cAMP-dependent transcription factor ATF-6 beta
, cAMP-responsive element-binding protein-like 1
, protein G13
, cAMP responsive elment binding protein-like 1
, cAMP response element binding protein-related protein