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anti-Human FXYD2 Antibodies:
anti-Mouse (Murine) FXYD2 Antibodies:
anti-Rat (Rattus) FXYD2 Antibodies:
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Human Monoclonal FXYD2 Primary Antibody for IHC (p), ELISA - ABIN559991
Flamez, Roland, Berton, Kutlu, Dufrane, Beckers, De Waele, Rooman, Bouwens, Clark, Lonneux, Jamar, Goldman, Maréchal, Goodman, Gianello, Van Huffel, Salmon, Eizirik: A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specific biomarker. in Diabetologia 2010
FXYD2 is functionally upregulated in ovarian clear cell carcinoma and may serve as a promising prognostic biomarker and therapeutic target of cardiac glycosides in OCCC
Recurrent FXYD2 p.Gly41Arg mutation is associated with isolated dominant hypomagnesaemia.
FXYD2b could regulate the Na,K-ATPase by modulating the effective membrane surface electrostatics near the ion binding sites of the pump.
our findings suggested that FXYD2c played a role in regulation of NKA activity by enhancing the expression of NKA in HK-2 cells upon hypertonic challenge.
PCBD1 (dimerization cofactor of HNF-1alpha) is coactivator of the HNF1B-mediated transcription necessary for fine tuning ATPase Na+/K+ transporting gamma 1 polypeptide (FXYD2) transcription in the distal convoluted tubule.
This is the first report demonstrating the potential utility of FXYD2 immunohistochemistry in the diagnosis of chromophobe renal cell carcinoma
findings confirm the presence of an FXYD2 peptide in the crab gill Na,K-ATPase and demonstrate that this peptide plays an important role in regulating enzyme activity
wild type HNF1B specifically induces FXYD2A transcription whereas all HNF1B mutants partially prevented it.
Datab propose human FXYD2gammaa as a novel beta cell-specific biomarker.
Study reveals, in various human tissues, the specific expression of FXYD2, which may associate with Na, K-ATPase in selected cell types and modulate its catalytic properties.
Data conclude that human proximal tubular cells respond to a hyperosmotic challenge with an increase in FXYD2 and Na,K-ATPase protein expression, though to a smaller absolute extent in patient cells.
the TM domain of FYXD2 effects the shift in apparent Na+ affinity
Activity of GLAST directs FXYD2 protein/gamma subunit to the cell surface, that leads to the activation of the astroglial sodium pump.
structures of the FXYD proteins (with emphasis on 1-4), as well as their dynamics and their associations with the lipid
results suggest that FXYD2 can mediate basolateral extrusion of magnesium from cultured renal epithelial cells and provide new insights into the understanding of the possible physiological roles of FXYD2 wild-type and mutant proteins.
Expression in transfectants reduces Na+ and K+ affinity of Na,K-ATPase. Endogenous expression in certain nephron segments correlates with low Na+ affinity in Na,K-ATPase.
FXYD2 activity may be a fundamental mechanism underlying the persistent hypersensitivity to pain induced by inflammation.
Data suggest that in pancreatic beta cells regulatory subunit of Na,K-ATPase FXYD2 plays a role in Akt signaling pathways associated with cell growth and proliferation.
The transcription factor Runx1 controls FXYD2 expression during the maturation of the somato-sensory system, partly through regulation of the tyrosine kinase receptor Ret.
Fxyd2 encodes three mRNAs that have tissue-specific expression patterns.
the gamma-subunit has an important role in the function of Na-K-ATPase to sustain the cellular cation balance over the plasma membrane in a hypertonic environment.
FXYD2 has a role in Na+ affinity and regulating thermal stability in mice
direct and critical role of the gamma-subunit on IMCD3 cell survival and/or adaptation in response to ionic hypertonic stress
This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.
ATPase, Na+/K+ transporting, gamma 1 polypeptide
, Na(+)/K(+) ATPase subunit gamma
, sodium pump gamma chain
, sodium/potassium-transporting ATPase subunit gamma
, FXYD domain-containing ion transport regulator 2
, sodium/potassium-transporting ATPase gamma chain
, Na,K-ATPase gamma
, gamma subunit of Na,K-ATPase
, FXTD domain-containing ion transport regulator 2
, gamma subunit of sodium potassium ATPase
, Sodium/potassium-transporting ATPase gamma chain