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hLodestar/HuF2 interacts with CDC5L (show CDC5L Proteins) and is involved in pre-mRNA splicing
TTF2 is the only ATP-dependent termination activity associated with Pol II transcription elongation complexes, is largely unaffected by template position, and is impervious to the phosphorylation state of the polymerase.
Importantly, the mitotic phenotype seen with TTF2-siRNA is rescued by expression of the siRNA-resistant GFP-tagged TTF2 proving that reduced TTF2 is responsible for the retention of RNA polymerase II on mitotic chromosomes.
Overexpression of TTF-2 during the palatogenesis may contribute to cleft palate.
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.
, RNA polymerase II termination factor
, human factor 2
, lodestar homolog
, lodestar protein
, transcription release factor 2
, transcription termination factor 2
, transcription termination factor, RNA polymerase II
, transcription termination factor 2-like