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anti-Human PTPN1 Antibodies:
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Human Polyclonal PTPN1 Primary Antibody for WB - ABIN1882122
Blincoe, Chidambaram, Salari, Bond, Evans, Gray-Kaufman, Griffey, Tranby, Garner-Johnson, Lee, Sorenson: Pharmacokinetic distribution of 67Cu(II)2[3,5-diisopropyl(carboxy-14C)salicylate]4 among murine tissues. in Current medicinal chemistry 2004
Show all 6 Pubmed References
Chicken Monoclonal PTPN1 Primary Antibody for IF, IP - ABIN967772
Bharadwaj, Ali, Ovsenek: Multiple components of the HSP90 chaperone complex function in regulation of heat shock factor 1 In vivo. in Molecular and cellular biology 2000
Show all 5 Pubmed References
Chicken Monoclonal PTPN1 Primary Antibody for IF, IP - ABIN967773
Gaits, Li, Bigay, Ragab, Ragab-Thomas, Chap: G-protein beta gamma subunits mediate specific phosphorylation of the protein-tyrosine phosphatase SH-PTP1 induced by lysophosphatidic acid. in The Journal of biological chemistry 1996
Show all 5 Pubmed References
Mouse (Murine) Polyclonal PTPN1 Primary Antibody for WB - ABIN1881705
Stuible, Tremblay: In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis. in Trends in cell biology 2010
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Human Monoclonal PTPN1 Primary Antibody for ELISA, WB - ABIN411571
Gan, Zhang, Buckels, Paterson, Jiang, Clemens, Zhang, Du, Chang, Frank: IGF-1R modulation of acute GH-induced STAT5 signaling: role of protein tyrosine phosphatase activity. in Molecular endocrinology (Baltimore, Md.) 2013
Human Polyclonal PTPN1 Primary Antibody for IP - ABIN440507
Tsou, Talia, Pinney, Kendzicky, Piera-Velazquez, Jimenez, Seibold, Phillips, Koch: Effect of oxidative stress on protein tyrosine phosphatase 1B in scleroderma dermal fibroblasts. in Arthritis and rheumatism 2012
this study highlights an important role for Nck1 (show NCK1 Antibodies) in fine-tuning IRE1alpha (show ERN1 Antibodies) expression and signaling that regulate PTP1B expression and subsequent activation of the PI3K (show PIK3CA Antibodies)-Akt (show AKT1 Antibodies) pathway in HepG2 cells.
In conclusion, HDAC6 (show HDAC6 Antibodies) might enhance aggressive melanoma cells progression via interacting with PTPN1, which was independent of its histone modifying activity.
PTP1B is widely expressed in the human breast gland with highest expression in myoepithelial cells and fibroblasts. Inhibition of PTP1B in D492 and HMLE affects cell-cell adhesion and induces anoikis-like effects.
The results of the present study highlight the expression quantitative trait loci enrichment and pleiotropy in psoriasis and schizophrenia, and also suggest a possible key role of the PTPN1 gene in the etiology of psoriasis
The structural fragments which are important for PTP1B inhibition were identified by naive Bayesian method and can be further exploited to design new molecules around the identified scaffolds. The descriptive and predictive modeling strategy applied in this study is capable of identifying PTP1B inhibitors from the large compound libraries
The gained results are observed not only the unbinding mechanism of IRK (show KCNJ12 Antibodies)-PTP1B complexes came from pulling force profile, number of hydrogen bonds, and interaction energy between IRK (show KCNJ12 Antibodies) and PTP1Bs but also described PTP1B's point mutations could variably change its binding affinity towards IRK (show KCNJ12 Antibodies).
these results suggest that inhibition of PTP1B activity is a promising new target in the treatment of colorectal cancer and the prevention of metastasis
the molecular mechanisms by which PTP1B and TC-PTP (show PTPN2 Antibodies) loss co-operates with other genetic aberrations will need to be elucidated to design more effective therapeutic strategies.
Experimental results indicate that methylmercury inhibits the activity of protein tyrosine phosphatase 1B, which in turn activates the epidermal growth factor receptor (show EGFR Antibodies)-p38 mitogen-activated protein kinase (show MAPK14 Antibodies) pathway that induces cyclooxygenase-2 (show PTGS2 Antibodies) expression.
The findings show that reduced PTP1B responses contribute to disease symptoms in part by enhancing S100A9 (show S100A9 Antibodies) expression during viral-associated chronic obstructive pulmonary disease exacerbations.
S-nitrosylation of endogenous SHP2 (show PTPN11 Antibodies) Phosphatase and PTP1B in endothelial insulin (show INS Antibodies) signaling has been demonstrated.
Under normoglycemia control and pod-PTP1B KO mice exhibited comparable renal functions. However, podocyte PTP1B disruption attenuated hyperglycemia-induced albuminuria and renal injury and preserved glucose control. Also, podocyte PTP1B disruption was accompanied with improved renal insulin (show INS Antibodies) signaling and enhanced autophagy with decreased inflammation and fibrosis.
Endothelial PTP1B deletion improves cardiac VEGF (show VEGFA Antibodies) signalling and angiogenesis and protects against chronic afterload-induced heart failure.
PTP1B inhibitors protect against atherosclerotic plaque formation in the LDLR (show LDLR Antibodies)(-/-) mouse model of atherosclerosis.
The results suggest a deficiency of PTP1B improves hypothalamic insulin (show INS Antibodies) sensitivity resulting in the attenuation of AgRP (show AGRP Antibodies) mRNA expression under HFD conditions.
cadherin 2 (CDH2 (show CDH2 Antibodies)) and CDH4 (show CDH4 Antibodies) cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B) and alpha- and beta-catenins.
this paper shows that PTP1B specifically regulates IgE-mediated STAT5 (show STAT5A Antibodies) pathway, but is redundant in influencing mast cell function in vivo
PTP1B/RNF213 (show RNF213 Antibodies)/alpha-KGDD pathway is critical for survival of HER2 (show ERBB2 Antibodies)(+) breast cancer, and possibly other malignancies, in the hypoxic tumour microenvironment
data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.
PTP-1B increased posthypoxia by about 30% and persisted for 2 weeks while Src kinase (show CSK Antibodies) inhibition attenuated the expected PTP-1B-increased expression.
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.
protein tyrosine phosphatase, non-receptor type 1
, tyrosine-protein phosphatase non-receptor type 1
, tyrosine-protein phosphatase non-receptor type 1-like
, protein tyrosine phosphatase, placental
, protein-tyrosine phosphatase 1B
, protein-protein-tyrosine phosphatase HA2
, protein-tyrosine phosphatase HA2
, protein tyrosine phosphatase 1b
, non-receptor protein tyrosine phosphatase
, phosphoprotein phosphatase
, tyrosine phosphatase 1B