Browse our TAB1 Proteins (TAB1)

Human TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) interaction partners

1. High TAB1 expression is associated with colorectal cancer.

2. TAB1 was identified as a functional target of miR (show MLXIP Proteins)-134, and the expression of TAB1 was increased by the transcription factors of NF-kappaB1 (show NFKB1 Proteins), c-Rel (show NFkBP65 Proteins), and ELK1 (show ELK1 Proteins) via miR (show MLXIP Proteins)-134.

3. we show that IL-1 (show IL1A Proteins) induces robust p38a (show MAPK14 Proteins) activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a (show MAPK14 Proteins) activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 (show DUSP1 Proteins) through a negative feedback to pp38, its basal activity is controlled by both TAB1 and MKP1 (show DUSP1 Proteins) through a positive feedback loop.

4. TAK1 (show MAP3K7 Proteins)/TAB1 expression in non-small cell lung carcinoma tissue is significantly increased and closely associated with patient clinical prognosis.

5. miR (show MLXIP Proteins)-29a repressed TAB1-mediated TIMP-1 (show TIMP1 Proteins) production in dermal fibroblasts, demonstrating that miR (show MLXIP Proteins)-29a may be a therapeutic target in SSc (show CYP11A1 Proteins).

6. Data indicate that mitogen-activated protein kinase (show MAPK1 Proteins) (MAPK) p38 (show MAPK1 Proteins) activation is triggered by AMP (show APRT Proteins)-activated protein kinases (AMPK (show PRKAA1 Proteins)) and mediated by TAB1 protein.

7. The amino acid sequence between positions 373 and 502 of TAB1 is required for TP interaction.

8. USP18 (show USP18 Proteins) inhibits NF-kappaB (show NFKB1 Proteins) and NFAT (show NFATC1 Proteins) activation during Th17 differentiation by deubiquitinating the TAK1 (show MAP3K7 Proteins)-TAB1 complex.

9. We found that endothelial TAK1 (show MAP3K7 Proteins) and TAB2 (show TAB2 Proteins), but not TAB1, were critically involved in vascular formation

10. TAK1 (show MAP3K7 Proteins) plays a critical role in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation.

Mouse (Murine) TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) interaction partners

1. our study uncovers that RNF114 (show RNF114 Proteins)-mediated ubiquitination and degradation of TAB1 activate the NF-kappaB (show NFKB1 Proteins) pathway during MZT, and thus directly link maternal clearance to early embryo development.

2. We confirmed that PGC (show PGC Proteins)-1b inhibited downstream inflammatory signals via binding with TAB1 and thus preventing TAB1/TAK1 (show NR2C2 Proteins) binding and TAK1 (show NR2C2 Proteins) activation.

3. The E3 ubiquitin ligase (show MUL1 Proteins) Itch inhibits p38alpha (show MAPK14 Proteins) signaling and skin inflammation through the ubiquitylation of Tab1.

4. TAB1 and TAB2 (show TAB2 Proteins) are required for activated macrophages, making TAB1 and TAB2 (show TAB2 Proteins) effective targets to control inflammation by modulating macrophage survival.

5. Both the MEKK1 (show MAP2K1 Proteins) PHD (show PDC Proteins) and TAB1 are critical for ES-cell differentiation

6. The enhanced JNK (show MAPK8 Proteins) and IkappaB kinase (show CHUK Proteins) activation in DUSP14 (show DUSP14 Proteins)-deficient T cells was attenuated by TAB1 short hairpin RNA knockdown.

7. TAB1 binding stabilizes active p38alpha (show MAPK14 Proteins) and induces rearrangements within the activation segment by helical extension of the Thr (show TRH Proteins)-Gly-Tyr (show TYR Proteins) motif, allowing autophosphorylation in cis (show CISH Proteins)

8. We found that endothelial TAK1 (show NR2C2 Proteins) and TAB2 (show TAB2 Proteins), but not TAB1, were critically involved in vascular formation

9. O-GlcNAcylation of TAB1 is required for full TAK1 (show NR2C2 Proteins) activation upon stimulation with IL-1 (show IL1A Proteins)/osmotic stress.

10. Epithelial TAK1 (show NR2C2 Proteins) activity is regulated through two unique, TAB1-dependent basal & TAB2 (show TAB2 Proteins)-mediated stimuli-dependent mechanisms.