Protein Summary

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Alternative names and synonyms associated with TAB3

• TGF-beta activated kinase 1 and MAP3K7 binding protein 3 (TAB3) antibody
• TGF-beta activated kinase 1/MAP3K7 binding protein 3 (Tab3) antibody
• TGF-beta activated kinase 1/MAP3K7 binding protein 3 (tab3) antibody
• TGF-beta activated kinase 1 and MAP3K7 binding protein 3 (Tab3) antibody

• 4921526G09Rik antibody
• map3k7ip3 antibody
• map3k7ip3l antibody
• mKIAA4135 antibody
• NAP1 antibody
• Show all synonym aliases
• si:ch211-232d19.8 antibody
• si:dkey-30h22.6 antibody

Protein level used designations for TAB3

NF-kappa-B-activating protein 1 , NFkB activating protein 1 , TAB-3 , TAK1-binding protein 3 , TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 , TGF-beta-activated kinase 1-binding protein 3 , mitogen-activated protein kinase kinase kinase 7 interacting protein 3 , mitogen activated protein kinase kinase kinase 7 interacting protein 3 , mitogen-activated protein kinase kinase kinase 7-interacting protein 3 , TGF-beta activated kinase 1/MAP3K7 binding protein 3 , mitogen-activated protein kinase kinase kinase 7-interacting protein 3-like , mitogen-activated protein kinase kinase kinase 7 interacting protein 3 like , LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3