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The combination of WES, genomic triangulation, and systems biology has uncovered perturbations in TGF-beta activated kinase 1 (show MAP3K7 Proteins) signaling as a novel pathogenic substrate for polyvalvular syndrome.
Our study provides insights into the mechanism of TAB3 regulating activity and suggests its important implications in triple negative breast cancer metastasis.
Data show that knockdown of transforming growth factor-activated kinase 1 (TAK1)-binding protein 3 (TAB3) inhibited proliferation of non-small cell lung cancer (NSCLC) cells.
TAB3 regulated ovarian cancer cell bioactivity and chemotherapy performance via the NF-kappaB (show NFKB1 Proteins) pathway.
Upregulation of miR (show MLXIP Proteins)-532-5p and subsequent suppression of the SESTD1 (show SESTD1 Proteins) and TAB3 genes represent an antiviral response aimed at limiting West Nile virus infection.
miR (show MLXIP Proteins)-30a in MSCs may participate in the immune dysregulation of the maternal-fetal interface during PE
miR (show MLXIP Proteins)-26b suppresses NF-kappaB (show NFKB1 Proteins) signaling and sensitizes hepatocellular carcinoma cells to doxorubicin-induced apoptosis by inhibiting the expression of TAK1 (show MAP3K7 Proteins) and TAB3.
conclude that TRIM38 (show TRIM38 Proteins) negatively regulates TNFalpha (show TNF Proteins)- and IL-1beta (show IL1B Proteins)-induced signaling by mediating lysosome-dependent degradation of TAB2 (show TAB2 Proteins)/3, two critical components in TNFalpha (show TNF Proteins)- and IL-1beta (show IL1B Proteins)-induced signaling pathways
Studies show that three proteins expressed in HEK (show EPHA3 Proteins)-293T cells (NAP1 (show IL8 Proteins), TANK and TBKBP1 (show TBKBP1 Proteins)) interact with TBK1 (show TBK1 Proteins).
MiR (show MLXIP Proteins)-23b suppresses IL-17 (show IL17A Proteins)-, tumor necrosis factor alpha (TNF-alpha (show TNF Proteins))- or IL-1beta (show IL1B Proteins)-induced NF-kappaB (show NFKB1 Proteins) activation and inflammatory cytokine expression by targeting TAB2 (show TAB2 Proteins), TAB3 and IKK-alpha (show CHUK Proteins).
Findings indicate that the absence of TAB3 plays a harmful role in ischemic heart disease
TAB2 (show TAB2 Proteins) and TAB3 are essential for B cell activation (show BLNK Proteins) leading to antigen-specific antibody responses, as well as B-1 and marginal zone B cell development.
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
NF-kappa-B-activating protein 1
, NFkB activating protein 1
, TAK1-binding protein 3
, TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
, TGF-beta-activated kinase 1-binding protein 3
, mitogen-activated protein kinase kinase kinase 7 interacting protein 3
, mitogen activated protein kinase kinase kinase 7 interacting protein 3
, mitogen-activated protein kinase kinase kinase 7-interacting protein 3
, TGF-beta activated kinase 1/MAP3K7 binding protein 3
, mitogen-activated protein kinase kinase kinase 7-interacting protein 3-like
, mitogen-activated protein kinase kinase kinase 7 interacting protein 3 like
, LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3