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anti-Human TICAM1 Antibodies:
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Human Polyclonal TICAM1 Primary Antibody for ICC, IF - ABIN266066
Hoebe, Du, Georgel, Janssen, Tabeta, Kim, Goode, Lin, Mann, Mudd, Crozat, Sovath, Han, Beutler: Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. in Nature 2003
Show all 26 Pubmed References
Human Polyclonal TICAM1 Primary Antibody for WB - ABIN1881885
Bin, Xu, Shu: TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. in The Journal of biological chemistry 2003
Show all 5 Pubmed References
Human Polyclonal TICAM1 Primary Antibody for IP, WB - ABIN1169062
Carty, Goodbody, Schröder, Stack, Moynagh, Bowie: The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. in Nature immunology 2006
Show all 3 Pubmed References
Human Polyclonal TICAM1 Primary Antibody for ELISA, ICC - ABIN4362350
Shi, Kehrl: MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. in The Journal of biological chemistry 2008
Human Polyclonal TICAM1 Primary Antibody for ELISA, WB - ABIN4362353
Bowen, Minns, Johnson, Mitchell, Hutton, Evans: Selective TRIF-dependent signaling by a synthetic toll-like receptor 4 agonist. in Science signaling 2012
These data indicate a novel role of the TLR3 (show TLR3 Antibodies)-TICAM-1 pathway in controlling miR (show MLXIP Antibodies)-21 levels in extracellular vesicles.
Findings suggest that Toll (show TLR4 Antibodies)/IL-1R domain-containing adapter-inducing IFN-beta (show IFNB1 Antibodies) may be involved in the epileptogenesis of temporal lobe epilepsy, which would make it a potential therapeutic target for the treatment of epilepsy.
The down regulation of TRIF (show TRIM69 Antibodies), TLR3 (show TLR3 Antibodies), and mitochondrial antiviral signaling protein (MAVS (show MAVS Antibodies)) expressions in chronic hepatitis C correlates with the disease severity and the outcome of hepatitis C virus infection
TRIM56 (show TRIM56 Antibodies) may act as a tumor suppressor in multiple myeloma through activation of TLR3 (show TLR3 Antibodies)/TRIF (show TRIM69 Antibodies) signaling pathway.
Data suggest that endosomal localization of TICAM2 (show TICAM2 Antibodies) is essential for TLR4 (show TLR4 Antibodies)-mediated type I interferon-inducing signaling from endosomes; TICAM2 (show TICAM2 Antibodies) acts as scaffold protein (show HOMER1 Antibodies) and activates TICAM1; N-terminal myristoylation allows TICAM2 (show TICAM2 Antibodies) to anchor to endosomal membrane. (TICAM2 (show TICAM2 Antibodies) = toll like receptor adaptor molecule-2 (show TICAM2 Antibodies); TICAM1 = toll like receptor adaptor molecule-1; TLR4 (show TLR4 Antibodies) = toll-like receptor 4 (show TLR4 Antibodies)) [REVIEW]
Data suggest that pro-death signals through TIR-domain-containing adapter-inducing interferon-beta (show IFNB1 Antibodies) (TRIF (show TRIM69 Antibodies)) are regulated by autophagy and propose that pro-apoptotic signalling through TRIF (show TRIM69 Antibodies)/RIPK1 (show RIPK1 Antibodies)/caspase-8 (show CASP8 Antibodies) occurs in fibrillary platforms.
Therefore, Seneca Valley virus suppressed antiviral interferon production to escape host antiviral innate immune responses by cleaving host adaptor molecules MAVS (show MAVS Antibodies), TRIF (show TRIM69 Antibodies), and TANK by its 3C protease.
TRIF (show TRIM69 Antibodies) gene may contribute to susceptibility of T2DM.
The NF-kappaB (show NFKB1 Antibodies) activated by dsRNA appears not to be the canonical p65 (show GORASP1 Antibodies)/p50 (show CD40 Antibodies) heterodimers.
We confirmed associations with papillary thyroid cancer and SNPs in FOXE1 (show FOXE1 Antibodies)/HEMGN (show HEMGN Antibodies), SERPINA5 (show SERPINA5 Antibodies) (rs2069974), FTO (show FTO Antibodies) (rs8047395), EVPL (show EVPL Antibodies) (rs2071194), TICAM1 (rs8120) and SCARB1 (show SCARB1 Antibodies) (rs11057820) genes. We found associations with SNPs in FOXE1 (show FOXE1 Antibodies), SERPINA5 (show SERPINA5 Antibodies), FTO (show FTO Antibodies), TICAM1 and HSPA6 (show HSPA6 Antibodies) and and follicular thyroid cancer
STING-mediated innate immune responses and dendritic cell maturation do not require TICAM-1 in myeloid lineage immune cells.
Mice with myeloid cell specific TIR-domain-containing adapter-inducing interferon-beta (show IFNB1 Antibodies) (TRIF (show RNF138 Antibodies)) knockout showed a trend towards accelerated onset of STZ-induced diabetes, while TRIF (show RNF138 Antibodies) deficiency resulted in reduced IDO (show IDO1 Antibodies) expression in vivo and in vitro. MyD88 (show MYD88 Antibodies) signaling in myeloid cells is a critical pathogenic factor in autoimmune diabetes, which is antagonized by TRIF (show RNF138 Antibodies)-dependent responses.
The TLR3 (show TLR3 Antibodies)/TICAM-1 pathway inhibits polyposis through suppression of c-Myc (show MYC Antibodies) expression and supports long survival in Apc (show APC Antibodies) (Min/+) mice.
Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs
TRIF (show RNF138 Antibodies) contributes to murine host defense during the initial response to leptospiral infection
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)-regulated apoptosis and the p53 (show TP53 Antibodies)/PCNA (show PCNA Antibodies)- and ATM (show ATM Antibodies)/ATR (show ATR Antibodies)-Chk1 (show CHEK1 Antibodies)/2-controlled DNA-damage response pathways.
Results show that Monophosphoryl lipid A-induced neutrophil and monocyte recruitment, expansion of bone marrow progenitors and augmentation of neutrophil adhesion molecule (show NCAM1 Antibodies) expression are regulated by both the MyD88 (show MYD88 Antibodies)- and TRIF (show RNF138 Antibodies)-dependent pathways.
TRIF (show RNF138 Antibodies) and STING interacted directly, through their carboxy-terminal domains, to promote STING dimerization, intermembrane translocation, and signaling.
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (show FOSL1 Antibodies) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (show TRAF3 Antibodies)), TIR domain-containing adapter inducing IFN-beta (show IFNB1 Antibodies) (TRIF (show RNF138 Antibodies)), and Tank-binding kinase 1 (TBK1 (show TBK1 Antibodies)) via impairing K63-linked polyubiquitination of TRAF3 (show TRAF3 Antibodies) and TRIF (show RNF138 Antibodies).
Inhibition of the Toll (show TLR4 Antibodies)/interleukin-1 receptor (TIR) domain-containing adapter-inducing interferon-beta (show IFNB1 Antibodies) signaling reduced permeability changes and apoptosis in endothelial cells exposed to lipopolysaccharide.
3D-models of rohu TLR3 (show TLR3 Antibodies)-TIR and zebrafish TRIF
The role of zebrafish (Danio rerio) TICAM1 in activating NF-kappaB (show NFKB1 Antibodies) and zebrafish type I IFN was described.
study focuses on the functional characterization of zebrafish TRIF; results show that the full length cDNA of zebrafish TRIF encodes a protein of 556 amino acids; TRIF is able to induce the IFN promoter as well as activate NF-kappaB (show NFKB1 Antibodies) response promoter
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response.
TIR domain containing adaptor inducing interferon-beta
, TIR domain-containing adapter molecule 1
, TIR domain-containing adapter protein inducing IFN-beta
, proline-rich, vinculin and TIR domain-containing protein B
, putative NF-kappa-B-activating protein 502H
, toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
, toll-interleukin I receptor domain containing adaptor molecule 1
, toll-like receptor adaptor molecule 1
, TIR domain-containing adapter molecule 1-like
, TIR domain-containing adaptor inducing interferon-beta
, toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta
, TIR-domain containing adaptor inducing IFN-beta