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anti-Human TICAM1 Antibodies:
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Human Polyclonal TICAM1 Primary Antibody for ICC, IF - ABIN266066
Hoebe, Du, Georgel, Janssen, Tabeta, Kim, Goode, Lin, Mann, Mudd, Crozat, Sovath, Han, Beutler: Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. in Nature 2003
Show all 25 Pubmed References
Human Polyclonal TICAM1 Primary Antibody for WB - ABIN1881885
Bin, Xu, Shu: TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. in The Journal of biological chemistry 2003
Show all 5 Pubmed References
Human Polyclonal TICAM1 Primary Antibody for IHC (fro), WB - ABIN550259
Sakaguchi, Irie, Kawabata, Yoshida, Maruyama, Kawakami: Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation. in Neuroscience letters 2011
Show all 4 Pubmed References
Human Polyclonal TICAM1 Primary Antibody for IP, WB - ABIN1169062
Carty, Goodbody, Schröder, Stack, Moynagh, Bowie: The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. in Nature immunology 2006
Show all 3 Pubmed References
Human Polyclonal TICAM1 Primary Antibody for ELISA, WB - ABIN4362353
Bowen, Minns, Johnson, Mitchell, Hutton, Evans: Selective TRIF-dependent signaling by a synthetic toll-like receptor 4 agonist. in Science signaling 2012
Human Polyclonal TICAM1 Primary Antibody for ELISA, ICC - ABIN4362350
Shi, Kehrl: MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. in The Journal of biological chemistry 2008
Data suggest that endosomal localization of TICAM2 (show TICAM2 Antibodies) is essential for TLR4 (show TLR4 Antibodies)-mediated type I interferon (show IFNA Antibodies)-inducing signaling from endosomes; TICAM2 (show TICAM2 Antibodies) acts as scaffold protein (show HOMER1 Antibodies) and activates TICAM1; N-terminal myristoylation allows TICAM2 (show TICAM2 Antibodies) to anchor to endosomal membrane. (TICAM2 (show TICAM2 Antibodies) = toll like receptor adaptor molecule-2 (show TICAM2 Antibodies); TICAM1 = toll like receptor adaptor molecule-1; TLR4 (show TLR4 Antibodies) = toll-like receptor 4 (show TLR4 Antibodies)) [REVIEW]
Data suggest that pro-death signals through TIR-domain-containing adapter-inducing interferon-beta (show IFNB1 Antibodies) (TRIF (show TRIM69 Antibodies)) are regulated by autophagy and propose that pro-apoptotic signalling through TRIF (show TRIM69 Antibodies)/RIPK1 (show RIPK1 Antibodies)/caspase-8 (show CASP8 Antibodies) occurs in fibrillary platforms.
Therefore, Seneca Valley virus suppressed antiviral interferon (show IFNA Antibodies) production to escape host antiviral innate immune responses by cleaving host adaptor molecules MAVS (show MAVS Antibodies), TRIF (show TRIM69 Antibodies), and TANK by its 3C protease.
TRIF (show TRIM69 Antibodies) gene may contribute to susceptibility of T2DM.
The NF-kappaB (show NFKB1 Antibodies) activated by dsRNA appears not to be the canonical p65 (show GORASP1 Antibodies)/p50 (show CD40 Antibodies) heterodimers.
We confirmed associations with papillary thyroid cancer and SNPs in FOXE1 (show FOXE1 Antibodies)/HEMGN, SERPINA5 (show SERPINA5 Antibodies) (rs2069974), FTO (show FTO Antibodies) (rs8047395), EVPL (show EVPL Antibodies) (rs2071194), TICAM1 (rs8120) and SCARB1 (show SCARB1 Antibodies) (rs11057820) genes. We found associations with SNPs in FOXE1 (show FOXE1 Antibodies), SERPINA5 (show SERPINA5 Antibodies), FTO (show FTO Antibodies), TICAM1 and HSPA6 (show HSPA6 Antibodies) and and follicular thyroid cancer
IL-12p70 production requires uptake of Streptococcus pneumoniae as well as the presence of the adaptor molecule TRIF (show TRIM69 Antibodies).
TIRF high-content imaging system simultaneously showed the expression pattern of EGFRs and EC50 value for CPT (show CHPT1 Antibodies)-induced apoptosis and necrosis in MCF-7, SK-BR-3 and JIMT-1 cancer cell line
involved in signaling that moderates the expression of heme oxygenase1 and il-8 (show IL8 Antibodies) after keratinocytes exposure to dinitrochlorobenzene
Using bone marrow derived macrophages from knockout mice we demonstrate that hBD3 (show DEFB103A Antibodies) suppresses the polyI:C-induced TLR3 (show TLR3 Antibodies) response mediated by TICAM1 (TRIF), while exacerbating the cytoplasmic response through MDA5 (IFIH1 (show IFIH1 Antibodies)) and MAVS (IPS1/CARDIF (show MAVS Antibodies)).
Versican (show Vcan Antibodies) is produced by Trif (show RNF138 Antibodies)- and type I interferon (show IFNA Antibodies)-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs
TRIF (show RNF138 Antibodies) contributes to murine host defense during the initial response to leptospiral infection
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)-regulated apoptosis and the p53 (show TP53 Antibodies)/PCNA (show PCNA Antibodies)- and ATM (show ATM Antibodies)/ATR (show ATR Antibodies)-Chk1 (show CHEK1 Antibodies)/2-controlled DNA-damage response pathways.
Results show that Monophosphoryl lipid A-induced neutrophil and monocyte recruitment, expansion of bone marrow progenitors and augmentation of neutrophil adhesion molecule (show NCAM1 Antibodies) expression are regulated by both the MyD88 (show MYD88 Antibodies)- and TRIF (show RNF138 Antibodies)-dependent pathways.
TRIF (show RNF138 Antibodies) and STING interacted directly, through their carboxy-terminal domains, to promote STING dimerization, intermembrane translocation, and signaling.
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (show FOSL1 Antibodies) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (show TRAF3 Antibodies)), TIR domain-containing adapter inducing IFN-beta (show IFNB1 Antibodies) (TRIF (show RNF138 Antibodies)), and Tank-binding kinase 1 (TBK1 (show TBK1 Antibodies)) via impairing K63-linked polyubiquitination of TRAF3 (show TRAF3 Antibodies) and TRIF (show RNF138 Antibodies).
These results suggested the importance of TRIF (show RNF138 Antibodies) in TLR2 (show TLR2 Antibodies) mediated foam cell formation via inflammatory mediators, including MCP-1 (show CPT1B Antibodies).
DENV replication and IFNalpha/beta, TNF-alpha (show TNF Antibodies), IL-12 (show IL12A Antibodies) and IL-18 (show IL18 Antibodies) in infected cultures at 24h were found. All of these parameters were significantly decreased after TRIF (show RNF138 Antibodies), MYD88 (show MYD88 Antibodies) or NF-kB inhibition
The authors demonstrate that, in addition to MyD88 (show MYD88 Antibodies), Yersinia pseudotuberculosis inhibits TRIF (show RNF138 Antibodies) signaling through the type III secretion system effector YopJ.
Results show that toll (show TLR4 Antibodies)/IL-1 (show IL1A Antibodies) domain-containing adaptor inducing IFN-beta (show IFNB1 Antibodies) (TRIF (show RNF138 Antibodies)) is essential for Toll (show TLR4 Antibodies)-like receptors TLR3 (show TLR3 Antibodies)- and TLR4 (show TLR4 Antibodies)-mediated innate immune responses in peritoneal mesothelial cells (PMCs).
Inhibition of the Toll (show TLR4 Antibodies)/interleukin-1 receptor (TIR) domain-containing adapter-inducing interferon-beta (show IFNB1 Antibodies) signaling reduced permeability changes and apoptosis in endothelial cells exposed to lipopolysaccharide.
3D-models of rohu TLR3 (show TLR3 Antibodies)-TIR and zebrafish TRIF
The role of zebrafish (Danio rerio) TICAM1 in activating NF-kappaB (show NFKB1 Antibodies) and zebrafish type I IFN was described.
study focuses on the functional characterization of zebrafish TRIF; results show that the full length cDNA of zebrafish TRIF encodes a protein of 556 amino acids; TRIF is able to induce the IFN promoter as well as activate NF-kappaB (show NFKB1 Antibodies) response promoter
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response.
TIR domain-containing adapter molecule 1
, TIR domain containing adaptor inducing interferon-beta
, toll-interleukin I receptor domain containing adaptor molecule 1
, toll-like receptor adaptor molecule 1
, TIR domain-containing adapter molecule 1-like
, TIR domain-containing adapter protein inducing IFN-beta
, proline-rich, vinculin and TIR domain-containing protein B
, putative NF-kappa-B-activating protein 502H
, toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
, TIR domain-containing adaptor inducing interferon-beta
, toll-interleukin 1 receptor domain-containing adapter protein inducing interferon-beta
, TIR-domain containing adaptor inducing IFN-beta