TICAM1 antibody (AA 115-143)

Catalog No. ABIN3029184

The Rabbit Polyclonal anti-TICAM1 antibody (ABIN3029184) specifically detects TICAM1 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for TICAM1 antibody (AA 115-143) (ABIN3029184)

Target: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TICAM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TICAM1 Antibody

Binding Specificity: AA 115-143

Purpose: TICAM1 Antibody

Purification: Antigen affinity

Immunogen: A portion of amino acids 115-143 from the human protein was used as the immunogen for this TICAM1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the TICAM1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TICAM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TICAM1

Target: TICAM1 (Toll-Like Receptor Adaptor Molecule 1 (TICAM1))

Alternative Name: TICAM1

Background: Involved in innate immunity against invading pathogens. Adapter used by< a href=../search_result.php?search_txt=TLR>TLR3and< a href=../search_result.php?search_txt=TLR>TLR4(through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins< a href=../search_result.php?search_txt=Tbk1>TBK1, TRAF6 and< a href=../search_result.php?search_txt=ripk>RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7,< a href=../search_result.php?search_txt=nf-kb>NF-kappa-Band FADD respectively.

UniProt: Q8IUC6

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades