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Human Monoclonal TLR4 Primary Antibody for ChIP, CyTOF - ABIN252522
Kessel, Toubi, Pavlotzky, Mogilner, Coran, Lurie, Karry, Sukhotnik et al.: Treatment with glutamine is associated with down-regulation of Toll-like receptor-4 and myeloid differentiation factor 88 expression and decrease in intestinal mucosal injury caused by ... in Clinical and experimental immunology 2008
Show all 72 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for BP, CyTOF - ABIN4360113
Rallabhandi, Bell, Boukhvalova, Medvedev, Lorenz, Arditi, Hemming, Blanco, Segal, Vogel: Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 45 Pubmed References
Human Polyclonal TLR4 Primary Antibody for IHC (p), WB - ABIN4886746
Li, Qian, Ju, Wang: Upregulation of Toll-like receptor 2 expression in colorectal cancer infected by human cytomegalovirus. in Oncology letters 2014
Show all 29 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for FACS - ABIN252065
Konno, Wakabayashi, Akashi-Takamura, Ishii, Kobayashi, Takahashi, Kusumoto, Saitoh, Yoshizawa, Miyake: A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. in Biochemical and biophysical research communications 2005
Show all 24 Pubmed References
Human Monoclonal TLR4 Primary Antibody for BP, CyTOF - ABIN4360167
Degraaf, Zasłona, Bourdonnay, Peters-Golden: Prostaglandin E2 reduces Toll-like receptor 4 expression in alveolar macrophages by inhibition of translation. in American journal of respiratory cell and molecular biology 2014
Show all 24 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for FACS - ABIN4360117
Mempel, Voelcker, Köllisch, Plank, Rad, Gerhard, Schnopp, Fraunberger, Walli, Ring, Abeck, Ollert et al.: Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet ... in The Journal of investigative dermatology 2003
Show all 23 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for BP, CyTOF - ABIN4360119
Basak, Pathak, Bhattacharyya, Mandal, Pathak, Kundu et al.: NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori ... in The Journal of biological chemistry 2005
Show all 22 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for FACS, ICC - ABIN4360164
Cognasse, Hamzeh, Chavarin, Acquart, Genin, Garraud: Evidence of Toll-like receptor molecules on human platelets. in Immunology and cell biology 2005
Show all 21 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for BP, ELISA - ABIN4360158
Scheel, Papavlassopoulos, Blunck, Gebert, Hartung, Zähringer, Seydel, Schromm: Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages. in Infection and immunity 2006
Show all 18 Pubmed References
Human Monoclonal TLR4 Primary Antibody for FACS - ABIN4360193
Zanoni, Navone, Lunardi, Tridente, Bason, Sivori, Beri, Dolcino, Valletta, Corrocher, Puccetti: In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes. in PLoS medicine 2006
Show all 16 Pubmed References
Asp299Gly and Thr399Ile polymorphisms seem not to be associated with the type 2 diabetes and prediabetes but Asp299Gly may contribute to diabetic retinopathy predisposition.
Evaluation of toll-like receptor 4 expression in human bone marrow mesenchymal stem cells by lipopolysaccharides from Shigella.
TLR4 and related MyD88/TIRAP pathway was involved in silica-induced inflammation in U937-differentiated macrophages
In response to HMGB1 stimulation, human aortic endothelial cells rapidly undergo ectodomain shedding of RAGE and TLR4, and thereby become insensitive to further HMGB1 stimulation.
TLR4 is a direct target of miR-760 in hypoxia-induced human pulmonary artery smooth muscle cells.
Surface plasmon resonance studies showed that HMGB1 and its fragments (A-box and B-box) individually interact with the TLR4/MD-2 receptor with different binding and kinetic parameters. Our study also reveals that HMGB1 likely activates TLR4 signaling through inducing TLR4/MD-2 dimerization.
Left atrial platelet TLR-2 and TLR-4 expression and serum HMGB-1 levels were higher in persistent Atrial fibrillation(AF) patients compared to paroxysmal AF patients. In the patient group, left atrial expression of TLR-2, 4 and HMGB-1 were significantly higher than the peripheral expression levels.
High frequency of genotype TT of TLR4 1363C>T was observed in patients with dermato-lymphangio-adenitis in obstructive lymphedema of lower limbs.
DC-SIGN mediates TLR4-regulated NFkappaB activation but not activation of p38 and JNK.
The findings provided new insights into the pathophysiology of liver fibrosis by characterizing Wnt2b as a novel endogenous suppressor of TLR4 signaling, maintaining tissue homeostasis during the early stage of hepatic fibrosis-associated liver diseases.
The results of this study indicated that TLR4 polymorphisms may be a genetic susceptibility factor for HCM in the Han Chinese population
the presence of polymorphism Asp299Gly gene TLR4 in patients co-infected with HIV/HCV indicates a high risk of metabolic disturbances
high expression of (TLR4) is associated with Type 2 diabetes mellitus.
The detection of higher frequencies of the TLR2, TLR4 and/or TLR9 polymorphisms in colorectal cancer (CRC) patients compared with the control groups highlight the role of these polymorphism in CRC development and cancer progression
Data suggest that the toll-like receptor 4 (TLR4) mutant-specific conformational alterations may help in deciphering the mechanism of loss-of-function mutations.
TLR4 and TLR9 mRNA were elevated in blood samples from celiac disease patients compared to the healthy controls
high TLR4 expression level during acute rejection was associated with adverse kidney allograft outcome
the results of the present study showed significantly higher mRNA expression levels for TLR4 180days post-transplantation in the graft dysfunction group compared to well functioning graft group
the expression levels of TLR4/MyD88 were positively correlated with the metastatic potential of breast cancer cells and tumors. The expression levels of TLR4/MyD88 may be used as a biomarker to evaluate the prognosis and guide the treatment of patients with breast cancer.
These results suggest that celastrol exerts its protective effect partly via inhibiting the TLR4mediated immune and inflammatory response in steatotic HepG2 cells.
these results suggest that constitutively active TLR4-induced inflammation in white adipose tissue is not sufficient to induce systemic insulin resistance, and that high fat diet-induced insulin resistance may require other signals in addition to TLR4-mediated inflammation.
our findings showed that very rapid antigen-specific antibody production is correlated with the TLR4-imprinted germinal centre response to AdV-based vaccine. These results provide additional evidence for the use of the AdV and a TLR agonist to induce humoral responses.
High-fat diet -induced TLR4 activation inhibited macrophage proliferation, leading to greater accumulation of recruited CD11c(+) adipose tissue macrophages.
miR-451 may relieve chronic inflammatory pain by inhibiting microglia activation-mediated inflammation via targeting TLR4.
Nitrated POPC showed anti-inflammatory potential, as assessed by the inhibition of inducible nitric oxide synthase (iNOS) expression in RAW 264.7 macrophages activated by the Toll-like receptor 4 (TLR4) agonist lipopolysaccharide (LPS) in a well-described in vitro model of inflammation
Studied anti-inflammatory effects of ethyl acetate extracts of E. sagittatum (Ying-Yang-Huo) and found it to inhibit toll-like receptor 4(TLR4)/ lymphocyte antigen 96(MD-2) thru the NF-kappaB signal pathway.
Upregulation of lncRNA CASC15 induced by VDR transcription factor facilitates cardiac hypertrophy via miR-432-5p/TLR4 axis.
Data suggest that toll-like receptor 4 (TLR4) is a central mediator and therapeutic target of cancer-induced muscle wasting.
These data demonstrate that TLR4 contributes to PABF caused by C. sinensis and TLR4 signaling may be a potential medical target for treatment of PABF.
intestinal epithelial TLR4 regulates metabolic syndrome through altered host-bacterial signaling
These data suggest that targeting TLR TIR domains may provide novel pharmacological targets to reduce or reverse TLR4-dependent pain behavior in the rodent.
We further show that EGFR is activated through toll-like receptor 4. Disruption of toll-like receptor 4 or the EGFR pathway led to reduced inflammatory activity and foam cell formation
Bone marrow malfunction arises early in obesity and depends on precursor-intrinsic TLR4.
Toxoplasma gondii ROP38 promotes the maturation of dendritic cells mediated by TLR4.
Local inhibition of TLR4 and MyD88 might reduce immune responses and ameliorate allograft rejection.
Results concluded that a hyperactive TLR4-NF-kappaB signal and higher level of cytokines are involved in susceptibility to depression in stressed obese mice.
these data showed that TLR4 knockout ameliorated high fat diet-induced cardiac contractile and intracellular Ca(2+) anomalies through inhibition of inflammation and ROS, possibly through a NF-kappaB/JNK-dependent activation of autophagy.
miR-711, which is upregulated by Adipoq, represses TLR4 signaling, acting therefore as a major mediator of the anti-inflammatory action of Adipoq.
TLR4 expression in placenta is up-regulated during maternal murine cytomegalovirus infection.
Two single nucleotide polymorphisms had significant effects on the milk production for Chinese Holstein, and these SNP could be used for molecular marker-assisted selection of milk production.
PGE2 downregulates LPS-induced inflammatory responses via the TLR4-NF-kappaB signaling pathway in bovine endometrial epithelial cells.
Based on the impact of both candidate genes,TLR4 and CACNA2D1, on udder health, linear or generalized linear mixed models was applied for testing the associations of SNPs located in the genes and clinical mastitis
a single nucleotide polymorphism of the bovine toll like receptor 4 gene (TLR4) in New Zealand (NZ) Holstein-Friesian x Jersey (HF x J) cross dairy cows was associated with milk production traits
STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells.
Studied genetic diversity of the Toll-like receptor gene TLR4 in Czech Red and Czech Red Pied cattle. Found 8 SNPs, which were grouped into 18 haplotypes.
TLR4 polymorphisms are associated with lower reproductive Performance.
As a pilot study, the present results revealed that identified SNPs in IL8 and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.
Transcription levels of TLR2, TLR4, and CD14 in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.
TLR2 and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 and TLR4 with the formation of NETs and change in surface architecture.
Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2) genes.
Studied bovine TLR4 gene in mastitis resistance by association as well as expression profiling analysis in crossbred cattle.
Findings indicate that intervertebral disc (IVD) cells constitutively express TLR4.
Data suggest that granulosa cells from dominant follicles express functional TLR2 and TLR4; granulosa cells appear to participate in innate immunity by responding to bacterial lipopolysaccharides/lipopeptides via TLR2 and TLR4 signaling pathways.
The expressions of host TLR2 and 4 genes were significantly higher in acidosis-resistant steers compared to those in acidosis-susceptible steers.
TLR4 and downstream adaptor molecules, transcription factors and cytokines were up-regulated when endometrial epithelial cells were stimulated with LPS
Data from an in vitro co-culture model suggest that an early response of endometrium in uterine infection is up-regulation of expression of TLR4 and CD14 (monocyte differentiation antigen CD14).
TLR2, 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (p65) were respectively detected.
Lipopolysaccharide upregulates the expression of rabbit TLR2 and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.
Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB expression, then inhibiting the release of mediators of inflammation as ICAM-1.
SNPs associated with incidence of digestive disorders
TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage
The elevated expression of TLR4 was detected after SAH and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH.
Data suggest that expression of TLR4 in intestinal mucosa can be regulated by dietary factors; here, flaxseed oil down-regulates expression of TLR4 in piglet model of necrotizing enterocolitis.
Actinobacillus pleuropneumoniae induces alveolar Macrophages to produce proinflammatory cytokines via upregulation of TLR4 and NF-kappaB.
The TWEAK-independent Fn14 activation augments TLR4-mediated inflammatory responses in the intestine of piglets.
These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 in Meishan weaned piglets.
Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS challenge.
At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.
Data suggest TLR2, TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2/TLR4.
TLR2 is required for the suppression of TLR4 signaling activation.
The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.
The role of TLR2, TLR4 and RP105/MD1 in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14, is reported.
Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.
Fish Oil attenuates the activation of the HPA axis induced by LPS challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.
Single nucleotide polymorphisms in TLR4 is associated with immune response to gram-negative bacterial infections.
The complete coding sequence of TLR4 gene in Min pig and 3 variants with single point mutations were obtained.
The relationship between TLR4 single nucleotide polymorphisms and the transcription levels of cytokines indicate that they are related to the modulation of the cytokine mediated immune response in pigs.
An alteration from cysteine to tryptophan at position 506 (C506W) caused loss of ability to induce nuclear factor-kappaB activation after lipid A stimulation.
These findings showed that TLR4 takes part in airway mucosal defense systems as a unique exogenous potentiator of electrolyte-water secretion from acinar cells, and that NO/cGMP/cGKsignaling is involved in this rapid TLR4 signaling pathway.
Three new alleles were isolated for exon 1 of the TLR4 gene.
similarity in TLR4 staining in macrophages, epithelium and vascular endothelium among dog, pig and cattle
A high level of conservation of TLR4 gene size and sequence, especially for the two last exons and particularly in the sequence corresponding to the LRRs and TIR domain, is observed between species
expression of TLR 2, 4 and 6 as transcript and protein in the placenta (chorioallantois) of 14 foals born alive
This study provides the basis for comparative investigations into the impact of different stimuli on the cellular expression of TLRs 2, 4 and 6 in order to find out if TLRs are involved in the pathogenesis of endometrial diseases and may help to understand as to why some mares develop persistent endometritis.
The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.
A low steady expression of TLR4, MD-2 and CD14 mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.
evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins
TLR4/MD-2 complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
, homolog of Drosophila toll
, lipopolysaccharide response
, Toll-like receptor4 protein
, Toll-like receptor 4-like protein