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TNRC6A Products

(Trinucleotide Repeat Containing 6A (TNRC6A))
This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008].

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Recommended TNRC6A Antibodies

Product
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Validations
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Datasheet
Reactivity Drosophila melanogaster
Application IHC, WB
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Cat. No. ABIN7273669
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
Cat. No. ABIN6243375
Quantity 200 μL
Datasheet Datasheet

Latest Publications for our TNRC6A products

Fu, Chen, Chen, Ge, Kang, Song, Li, Feng, Huo, He, Hou, Chen, Xu: "Crosstalk between alternative polyadenylation and miRNAs in the regulation of protein translational efficiency." in: Genome research, Vol. 28, Issue 11, pp. 1656-1663, (2019) (PubMed).

Jeppesen, Fenix, Franklin, Higginbotham, Zhang, Zimmerman, Liebler, Ping, Liu, Evans, Fissell, Patton, Rome, Burnette, Coffey: "Reassessment of Exosome Composition." in: Cell, Vol. 177, Issue 2, pp. 428-445.e18, (2019) (PubMed).

Seth, Hsieh, Jamal, Wang, Gygi, Jain, Coller, Stamler: "Regulation of MicroRNA Machinery and Development by Interspecies S-Nitrosylation." in: Cell, Vol. 176, Issue 5, pp. 1014-1025.e12, (2019) (PubMed).

Jung, Seong, Jeon, Kwon, Song: "MicroRNAs of miR-17-92 cluster increase gene expression by targeting mRNA-destabilization pathways." in: Biochimica et biophysica acta. Gene regulatory mechanisms, Vol. 1861, Issue 7, pp. 603-612, (2018) (PubMed).

Rajgor, Sanderson, Amici, Collingridge, Hanley: "NMDAR-dependent Argonaute 2 phosphorylation regulates miRNA activity and dendritic spine plasticity." in: The EMBO journal, Vol. 37, Issue 11, (2018) (PubMed).

Chen, Gao: "MicroRNAs recruit eIF4E2 to repress translation of target mRNAs." in: Protein & cell, Vol. 8, Issue 10, pp. 750-761, (2017) (PubMed).

Ahmed, Kren, Abedin, Vogel, Shaughnessy, Nacusi, Korman, Li, Dehm, Zimmerman, Niehans, Unger, Trembley: "CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: dose and molecular mechanisms of response in xenograft prostate tumors." in: Oncotarget, Vol. 7, Issue 38, pp. 61789-61805, (2016) (PubMed).

Kamenska, Lu, Kubacka, Broomhead, Minshall, Bushell, Standart: "Human 4E-T represses translation of bound mRNAs and enhances microRNA-mediated silencing." in: Nucleic acids research, Vol. 42, Issue 5, pp. 3298-313, (2014) (PubMed).

Bukong, Hou, Kodys, Szabo: "Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells." in: Hepatology (Baltimore, Md.), Vol. 57, Issue 1, pp. 70-80, (2013) (PubMed).

Meijer, Kong, Lu, Wilczynska, Spriggs, Robinson, Godfrey, Willis, Bushell: "Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation." in: Science (New York, N.Y.), Vol. 340, Issue 6128, pp. 82-5, (2013) (PubMed).

Synonyms and alternative names related to TNRC6A

trinucleotide repeat containing 6a (Tnrc6a), trinucleotide repeat containing 6A (TNRC6A), 2010321I05Rik, 3110054G10Rik, AW557223, CAGH26, D130023A07Rik, GW1, GW182, Tnrc6, TNRC6

Protein level used designations for TNRC6A

  • trinucleotide repeat-containing gene 6A protein
  • GW182 autoantigen
  • CAG repeat protein 26
  • EDIE
  • EMSY interactor protein
  • glycine-tryptophan protein of 182 kDa
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