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Human IL17RD Protein expressed in HEK-293 Cells - ABIN2723368
Mellett, Atzei, Bergin, Horgan, Floss, Wurst, Callanan, Moynagh: Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions. in Nature communications 2015
Low SEF (show TFCP2 Proteins) expression is associated with Epithelial-Mesenchymal Transition in Breast Cancer and thus Metastasis in breast Cancer.
Taken together, these data suggest evidence that loss of hSef may be a critical event facilitating tumor dissemination of prostate cancer through alteration of EMT (show ITK Proteins).
IL17RD negatively regulates Toll-like receptor (TLR)-induced responses.
Demonstrate SEF (show TFCP2 Proteins) expression in a healthy ovary during folliculogenesis and suggest hormonal regulation of its expression may be an important factor involved in intra-ovarian control mechanisms.
Downregulation of Dusp6, Sprouty4, and Sef--negative modulators of FGF2/ERK1/2 signaling--was present in eutopic endometria of adenomyosis, which may play critical roles in the development of adenomyosis.
These results reveal Sef-S actives Lys63-linked TAK1 (show MAP3K7 Proteins) polyubiquitination on lysine 209, induces TAK1 (show MAP3K7 Proteins)-mediated JNK (show MAPK8 Proteins) and p38 (show CRK Proteins) activation and also results apoptosis in 293T cells.
FGF17 (show FGF17 Proteins) and IL17RD prpopsed as the two top candidates in the entire proteome on the basis of a statistical test of their protein-protein interaction patterns to proteins known to be altered in congenital hypogonadotropic hypogonadism.
Downregulation of SEF (show TFCP2 Proteins) mRNA is associated with prostate cancer.
Orphan receptor (show NR1D2 Proteins) IL-17RD tunes IL-17A (show IL17A Proteins) signalling and is required for neutrophilia.
This study establishes Sef (show TFCP2 Proteins) as a feedback antagonist of proinflammatory cytokines and highlights its potential to regulate the crosstalk between proinflammatory cytokine receptors and receptor tyrosine kinases.
Deficiency of IL-17RD expression in cells leads to enhanced pro-inflammatory signalling and gene expression in response to TLR stimulation, and Il17rd(-/-) mice are more susceptible to TLR-induced septic shock.
Demonstrate SEF expression in a healthy ovary during folliculogenesis and suggest hormonal regulation of its expression may be an important factor involved in intra-ovarian control mechanisms.
these studies indicate that Sef has specific roles in osteoblast and osteoclast lineages and that its absence results in increased osteoblast and osteoclast activity with a net increase in cortical bone mass.
Since expression of IL-17 (show IL17A Proteins) is elevated in 3-month-old MRL/lpr (show FAS Proteins) mice, we suggest that it plays a role in the pathophysiology of autoimmune dacryoadenitis in these mice.
Over-expressing Sef specifically in the lens of transgenic mice led to impaired lens and eye development that resulted in microphthalmia.
Fgf8 (show FGF8 Proteins), Spry2 (show SPRY2 Proteins) and Sef belong to a synexpression group and may functionally interact during mouse embryonic development
Sef exerts its inhibitory effects at the level of FGFR and upstream of Ras providing an additional level of negative regulation of FGF signaling
Sef and Sproutys function synergistically to regulate Gbx2 (show GBX2 Proteins) expression in the anterior hindbrain.
Here we demonstrated that both extracellular and transmembrane domains of Sef contributed to Sef-mediated negative regulation of FGF signaling.
This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin (PMID: 19079364). The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling (PMID: 21663947, 18096367).
interleukin 17 receptor D
, interleukin-17 receptor D-like
, IL-17 receptor D
, interleukin-17 receptor D
, interleukin-17 receptor-like protein
, sef homolog
, similar expression to FGF genes protein