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S100A12 binds to CD36 (show CD36 Proteins) in the low nanomolar range at the CD36 (show CD36 Proteins) thrombospondin-1 (show THBS1 Proteins) binding site.
data on the antimicrobial activity of S100A12 have been reported. Proinflammatory role of S100A12 is supported by another newly found receptor, Toll-like receptor 4 (TLR4 (show TLR4 Proteins)).
Report role of fecal S100A12 assay in the diagnosis and management of inflammatory bowel disease.
The aim of this mini-review was to outline the pleiotropic actions of S100A12 and to highlight the potential clinical importance of this protein in kidney and cardiovascular diseases. [review]
Elevated S100A8 (show S100A8 Proteins) and S100A9 (show S100A9 Proteins) gene expression in SP-infected HMEECs and in the middle ear mucosa of OM, minor co-localized with neutrophil markers suggests that middle ear epithelial cell secretion of S100A8 (show S100A8 Proteins) and S100A9 (show S100A9 Proteins) may play a role in the pathogenesis of recurrent and chronic OM
Expression of S100A8 (show S100A8 Proteins), S100A9 (show S100A9 Proteins) and S100A12 is modulated by eicosapentaenoic acid and docosahexaenoic acid during Inflammation in adipose tissue and mononuclear cells.
The binding interface between S100A12 and the V domain of RAGE (show AGER Proteins) has been identified and mapped.
S100A12 functions as a proinflammatory cytokine and activates dermal fibroblasts, causing dermal fibrosis
S100A9 (show S100A9 Proteins) and S100A12 may have a role in the pathogenesis of pneumonia: S100A9 (show S100A9 Proteins) and CXCL1 (show CXCL1 Proteins) may contribute solely in mild pneumonia, and CCL5 (show CCL5 Proteins) and CXCL11 (show CXCL11 Proteins) may contribute in severe pneumonia.
These data suggest that S100A12 is part of an innate and adaptive inducible antimicrobial network that contributes to host defense against mycobacteria in infected macrophages
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.
, S100 calcium-binding protein A12 (calgranulin C)
, calcium-binding protein in amniotic fluid 1
, calgranulin C
, extracellular newly identified RAGE-binding protein
, migration inhibitory factor-related protein 6
, neutrophil S100 protein
, protein S100-A12
, S100 calcium-binding protein A12
, RAGE-binding protein
, cornea-associated antigen