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SIGIRR Antigen Profile
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity).
Alternative names and synonyms associated with SIGIRR
single Ig and TIR domain containing (SIGIRR) ELISA Kit
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr) ELISA Kit
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (sigirr) ELISA Kit
single Ig and TIR domain containing (Sigirr) ELISA Kit
TIR8 ELISA Kit
AI256711 ELISA Kit
sc:d148 ELISA Kit
RGD1306732 ELISA Kit
Protein level used designations for SIGIRR
single Ig IL-1-related receptor
, single Ig IL-1R-related molecule
, single immunoglobulin domain IL1R1 related
, single immunoglobulin domain-containing IL1R-related protein
, toll/interleukin-1 receptor 8
, single Ig IL-1 receptor related protein
, single Ig IL-1R-related protein