SIGIRR Products
(Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
Categories
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity).
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Featured SIGIRR Categories
SIGIRR Antibodies
High quality antibodies with extensive validation data.
SIGIRR ELISA Kits
Reliable ELISA kits for a wide range of species.
SIGIRR Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SIGIRR Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7437203
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7437206
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN7169723
Quantity
100 μL
Datasheet
Datasheet
Recommended SIGIRR ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4884521
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6386238
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730776
Quantity
96 tests
Datasheet
Datasheet
Recommended SIGIRR Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319981
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN7198052
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3130344
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SIGIRR products
: "The Toll-IL-1 receptor adaptor family grows to five members." in: Trends in immunology, Vol. 24, Issue 6, pp. 286-90, (2003) (PubMed).: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, (2003) (PubMed).
: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, (2002) (PubMed).
Synonyms and alternative names related to SIGIRR
single Ig and TIR domain containing (SIGIRR), single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr), single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (sigirr), single Ig and TIR domain containing (Sigirr), AI256711, RGD1306732, sc:d148, TIR8Protein level used designations for SIGIRR
- single Ig IL-1-related receptor
- single Ig IL-1R-related molecule
- single immunoglobulin domain IL1R1 related
- single immunoglobulin domain-containing IL1R-related protein
- toll/interleukin-1 receptor 8
- single Ig IL-1 receptor related protein
- single Ig IL-1R-related protein
- TIR8
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