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anti-Human ACP5 Antibodies:
anti-Mouse (Murine) ACP5 Antibodies:
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Human Polyclonal ACP5 Primary Antibody for WB - ABIN513079
Lozano, Fernández-de-Castro, Portal-Núñez, López-Herradón, Dapía, Gómez-Barrena, Esbrit: The C-terminal fragment of parathyroid hormone-related peptide promotes bone formation in diabetic mice with low-turnover osteopaenia. in British journal of pharmacology 2011
Show all 3 Pubmed References
Human Polyclonal ACP5 Primary Antibody for WB - ABIN513078
Leung, Pickarski, Zhuo, Masarachia, Duong: The effects of the cathepsin K inhibitor odanacatib on osteoclastic bone resorption and vesicular trafficking. in Bone 2011
Human Polyclonal ACP5 Primary Antibody for IF (p), IHC (p) - ABIN872754
Sun, Zhao, Li, Wang, Nie, Peng, Wang, Zhang, Tian, Li, Song, Wang, Xu, Tian, Zhao, Xu, Zhong, Han, Ling, Chang, Li: Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity. in Cell discovery 2016
Human Polyclonal ACP5 Primary Antibody for ELISA, ICC - ABIN4361606
Ma, Fang, Jiang, Zhang, Wang, Zhang, Chen: Bone mesenchymal stem cell secretion of sRANKL/OPG/M-CSF in response to macrophage-mediated inflammatory response influences osteogenesis on nanostructured Ti surfaces. in Biomaterials 2018
Human Monoclonal ACP5 Primary Antibody for IHC, ELISA - ABIN1724877
Janckila, Lin, Wu, Ku, Yang, Lin, Lee, Yam, Chao: Serum tartrate-resistant acid phosphatase isoform 5a (TRACP5a) as a potential risk marker in cardiovascular disease. in Clinica chimica acta; international journal of clinical chemistry 2011
serum level of TRACP5b may be used as a sensitive indicator of bone tumors
high expression of ACP5 correlates with tumor progression and may serve as a potential prognostic biomarker in lung AD.
TRACP-5b level is significantly associated with the OPG level and with the severity and extent of coronary atherosclerosis in coronary artery disease patients
Adipokine tartrate-resistant acid phosphatase 5a (TRAP 5a) serum levels correlated positively to anthropometric obesity parameters but not to metabolic syndrome risk factors, indicating that serum TRAP 5a is associated with pathological adipose tissue expansion.
TRAP promotes metastasis-related cell properties in MDA-MB-231 breast cancer cells via TGFbeta2/TbetaR and CD44, thereby identifying a potential signaling mechanism associated to TRAP action in breast cancer cells.
Serum TRAcP5b activity was associated with density of TRAcP-positive osteoclasts in the subchondral bone of medial tibia plateaux. TRAcP-positive osteoclasts were more abundant in people with symptomatic knee osteoarthritis compared to controls. Serum TRAcP5b activity was associated with baseline pain and pain change.
Although serum procollagen type-1 N-terminal propeptide (PINP) levels were not found to be different, tartrate-resistant acid phosphatase type 5b isoform (TRACP 5b) levels were significantly higher in the control group.
Nidogen-2, a protein shown to be expressed intracellularly and for secretion by pre-adipocytes, was shown to interact, through its globular G3 domain, with TRAP 5a in vitro.
Tartrate-resistant acid phosphatase deficiency in plasmacytoid dendritic cells leads to increased IFNalpha production, providing at least a partial explanation for how ACP5 mutations cause lupus in the context of spondyloenchondrodysplasia. Detection of ACP5 missense variants in a lupus cohort suggests that impaired tartrate-resistant acid phosphatase functioning may increase susceptibility to sporadic lupus
Biallelic ACP5 mutations are associated with autoimmune cytopenias.
Severe short stature can be the only presenting sign of ACP5 deficiency and the latter could therefore be considered as a rare cause in the differential diagnosis of severe, proportionate growth failure.
Spondyloenchondrodysplasia (SPENCD) is a rare autosomal recessive skeletal dysplasia caused by recessive mutations in the ACP5 gene, and it is characterized by the persistence of chondroid tissue islands within the bone. [review]
Data show that the levels of serum vascular endothelial growth factor (VEGF) and tartrate resistant acid phosphatase (TRacp-5b) are higher in multiple myeloma with cytogenetic abnormalities.
A diverse spectrum of spondyloenchondrodysplasia phenotypes due to mutations in ACP5 has been presented.
We identified five new biomarkers: GDF15, osteonectin, TRAP5, TWEAK, and YKL40 as being promising markers for monitoring bone metastases.
Trap-5b is overexpressed in renal cell carcinoma patients with bone metastasis and bone resorption.
Serum levels of NTx and TRACP5b are sensitive and simple biomarkers to indicate aberrant bone metabolism in giant cell tumor of bone, and they may have a clinical significance in GCT diagnosis.
TRACP5a may be a promising chronic inflammatory marker and may play a prognostic role in cancer cachexia.
TRACP5b has limited utility as a single marker of metabolic bone disease treatment.
Immunohistochemistry revealed that ACP5 expression was positively correlated with FoxM1 expression in human HCC tissues, and their coexpression was associated with poor prognoses
Cows with a low tartrate-resistant acid phosphatase (TRAP) activity are at risk of developing milk fever in comparison to cows with high TRAP activity.
This study reported a fluorometric method for measuring tartrate-resistant acid phosphatase isoform 5b and reported on the activity in the blood of cattle through development.
TRAP and nidogen-2 co-localized in adipose tissue cells in situ.
Uteroferrin is a cytokine secreted by uterine glands in response to progesterone that promotes fetal erythropoiesis at various stages of pregnancy.
Supraphysiologic oscillatory fluid shear induces upregulation of osteoclastic activity, measured by tartrate-resistant acid phosphatase activity and formation of mineral resorption pits.
Pax6 binds endogenously to the proximal region of the tartrate acid phosphatase (TRAP) gene promoter and suppresses nuclear factor of activated T cells c1 (NFATc1)-induced TRAP gene expression.
Serum TRAP levels were lower in mice receiving eggshell calcium citrate malate than those receiving eggshells calcium malate.
tartrate resistant acid phosphatase
TRAP is not essential for the formation of the epiphyseal vascular network.
dephosphorylation of Man6P-containing lysosomal proteins requires the concerted action of Acp2 and Acp5 and is needed for hydrolysis and removal of degradation products
Accumulation of vesicles in the cytoplasm of mutant osteoclasts indicates a novel function for tartrate-resistant acid phosphatase in modulating intracellular vesicular transport in osteoclasts
USF1 and USF2 play a functional role in RANKL-dependent TRAP expression during osteoclast differentiation.
TRACP expression is a target for regulation by the macrophage/osteoclast transcription factor PU.1 and the osteoclast commitment factor MiTF
YY1 plays a functional role in RANKL-mediated TRAP gene expression during osteoclast differentiation.
distinct tartrate-resistant acid phosphatase promoter regions have distinct roles in gene regulation in transgenic mice
MMP-2 and MMP-9 expression by TRAP positive mononuclear and multinucleated cells are involved in articular cartilage destruction in CIA.
TRAP release is due to secretion, rather than cell death
TRACP is important for polarizing responses in naive T cells to antigen-presented dendritic cells.
both synthesis as well as degradation of collagen are increased when TRAP is absent in mice at 8 weeks and 6 months of age, showing that TRAP has an important role in the metabolism of collagen
transcriptional activity of the Tracp gene, in pre-osteoclastic cells, is negatively regulated by the binding of PARP-1 protein to a potential consensus sequence located in its promoter region
prolonged hypoxia induces the formation of TRAP-positive osteoclast-like cells, suggesting the occurrence of an autocrine mechanism for osteoclastogenesis
Over-expression of monomeric tartrate resistant acid phosphatase, but not the dimeric form in adipose tissue leads to early onset spontaneous hyperplastic obesity
the effect of metal ion substitution on the mechanism of catalysis
characterization and proteolytic analysis of uteroferrin
This gene encodes an iron containing glycoprotein which catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is the most basic of the acid phosphatases and is the only form not inhibited by L(+)-tartrate.
, tartrate-resistant acid ATPase
, tartrate-resistant acid phosphatase type 5
, acid phosphatase 5, tartrate resistant
, acp5 protein
, acid phosphatase type 5
, tartrate-resistant acid phosphatase
, type 5 acid phosphatase
, tartrate resistant acid phosphatase
, Tartrate-resistant acid phosphatase type 5
, acid phosphatase type V