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results of our study suggest that high expression of Atp6v1c1 affects the actin structure of cancer cells such that it facilitates breast cancer metastasis
Immunohistochemical localization of C1 subunit of V-ATPase (ATPase C1) in oral squamous cell cancer and normal oral mucosa.
proximal promoter region contains cis (show CISH Proteins)-acting elements required for expression in cancer cells
Atp6v1c1 RNAi knockdown gene therapy mediated by AAV-shRNA-Atp6v1c1 is a promising novel therapeutic approach for the treatment of bone erosion and inflammatory related diseases, such as periodontitis and rheumatoid arthritis.
Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis.
Study demonstrates that Atp6v1c1 is an essential component of the osteoclast proton pump at the osteoclast ruffled border and that it may regulate F-actin ring formation in osteoclast activation.
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.
V-type proton ATPase subunit C 1
, V-ATPase subunit C 1
, vacuolar proton pump subunit C 1
, ATPase, H+ transporting, lysosomal V1 subunit C1
, ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
, Vacuolar proton pump subunit C 1
, V-type proton ATPase subunit C 1-like
, H(+)-transporting two-sector ATPase, subunit C
, H+ -ATPase C subunit
, H+-transporting ATPase chain C, vacuolar
, V-ATPase C subunit
, subunit C of vacuolar proton-ATPase V1 domain
, vacuolar ATP synthase subunit C
, vacuolar proton pump C subunit
, vacuolar proton pump, 42-kD subunit
, vacuolar proton-ATPase, subunit C, VI domain
, vacuolar H+ -ATPase C subunit
, ATPase, H+ transporting, V1 subunit C
, ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C
, ATPase, H+ transporting, lysosomal, V1 subunit C
, V-ATPase subunit C 1-A
, V-type proton ATPase subunit C 1-A
, vacuolar proton pump subunit C 1-A