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anti-Human FTL Antibodies:
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Polyclonal FTL Primary Antibody for ELISA, WB - ABIN539690
Hatakeyama, Okauchi, Hua, Keep, Xi: Deferoxamine reduces neuronal death and hematoma lysis after intracerebral hemorrhage in aged rats. in Translational stroke research 2013
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Human Polyclonal FTL Primary Antibody for ELISA, EIA - ABIN451634
Gu, Xu, Han, Dai, Hao, Wang, Gu, Xu, Cao: The internalization pathway, metabolic fate and biological effect of superparamagnetic iron oxide nanoparticles in the macrophage-like RAW264.7 cell. in Science China. Life sciences 2011
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Human Monoclonal FTL Primary Antibody for WB - ABIN534423
Arosio, Levi: Ferritin, iron homeostasis, and oxidative damage. in Free radical biology & medicine 2002
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Ferritin is up-regulated by inflammation and exhibits cytokine-like activity in periodontal ligament cells inducing a signaling cascade through transferrin receptor via ERK/P38 MAPK.
The combination of serum ferritin and CA125 provides the higher diagnostic accuracy to screen for epithelial ovarian cancer (EOC). Serum ferritin could serve as an EOC biomarker to complement the standard CA125 test.
iron overload due to impaired ferritinophagy or other cause(s) is likely to initiate prion-like spread of alpha-syn and ferritin, creating retinal iron dyshomeostasis and associated cytotoxicity. Since over-expression of alpha-syn is a known cause of Parkinson's disease.
Overexpression of FTL gene in metaplastic cells; could play a role in the differentiation of gastric cells into intestinal metaplasia
This study demonstrated that serum ferritin is a strong and independent prognostic factor associated with early death, induction failure, incidence of relapse, and OS in AML patients treated by intensive chemotherapy.
High serum ferritin (SF) and the overall survival of allogeneic hematopoietic SF was only significantly associated with prolonged RBC transfusion dependence post-transplantation.
CD16 expression and morphological maturity of neutrophils are associated with higher iron ferritin levels in major beta-thalassemia.
Mossbauer spectra of human liver ferritin and its pharmaceutical analogues Ferrum Lek and Maltofer(R) measured at various temperatures, are reported.
Determining serum ferritin is a convenient and nonexpensive method to determine the outcome of the treatment of the cases with oral squamous cell carcinoma . Its potential as prognostic marker could not be overlooked
The functional significance of the observed patch of carboxylate side chains and resulting metallocluster for biomineralization emerges from the lower iron oxidation rate measured in the E60AE61AE64A variant of human L-ferritin, leading to the proposal that the observed metallocluster corresponds to the suggested, but yet unobserved, nucleation site of L-ferritin
The clinical measurement of ferritin in cerebrospinal fluid is a better biomarker than serum levels of ferritin for diagnosing and assessing the progression of amyotrophic lateral sclerosis patients.
Our patient's transferrin saturation was 27% and HFE analysis revealed that she had neither H63D nor C282Y mutations that are known to predispose to hemochromatosis. Besides being an iron storage protein, ferritin is also one of the so-called acute phase proteins
This is the first Australian report of the c.-167 C>T mutation in a large family with multiple affected individuals.
fumarate increases ferritin gene transcription by activating the NRF2 (nuclear factor [erythroid-derived 2]-like 2) transcription factor.
there is no significant relationship between serum ferritin concentrations and depressive symptoms among Chinese adults.
Data suggest that, in homopolymeric H-subunit ferritin (HuHF), iron oxidation proceeds with a 2:1 Fe(II):O(2) stoichiometry at iron level of 2 Fe(II) atoms/H-subunit with generation of H2O2; L-subunit-rich heteropolymeric ferritin also facilitates iron oxidation at the ferroxidase center and additionally promotes oxidation at the mineral surface once iron-binding capacity has been exceeded.
Baseline serum ferritin (SF) did not influence bloodstream infections (BSIs), but higher levels resulted in more invasive fungal infections (IFIs)
High serum ferritin expression is associated with metabolic syndrome.
Hepatitis E virus ORF1 encoded macro domain protein interacts with light chain subunit of human ferritin and inhibits its secretion.
indicate an important role of ferritin light chains in neurodegeneration
Ferritin H subunit gene is specifically expressed in melanophore precursor-derived white pigment cells
Transmission electron microscopy shows a clear selectivity of alkylated ferritin adsorption onto the PCL phase while wild ferritin predominantly adsorbs onto the PDTD phase.
Ferritin is considered the major iron storage protein which maintains a large iron core in its cavity and has ferroxidase activity. (Review)
Analysis of Ftl-/- mice revealed systemic and brain iron dyshomeostasis, without any noticeable signs of neurodegeneration.
Noncoding G-to-T transversion (c.-168G>T) located in the iron response element (IRE) of the gene coding for ferritin light chain (FTL) cosegregated with cataract in the family.
Hx plays an important role in controlling iron distribution within brain, thus suggesting its involvement in iron-related neurodegenerative diseases.
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes.
ferritin L subunit
, ferritin L-chain
, ferritin light chain
, ferritin light polypeptide-like 3
, ferritin H subunit A
, ferritin heavy chain 2
, ferritin heavy chain A
, ferritin L subunit 1
, ferritin, light polypeptide
, ferritin light-chain
, ferritin light chain 1
, ferritin light chain 2