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Human Microsomal Triglyceride Transfer Protein (MTTP) interaction partners

1. MTP polymorphisms (493G/G, G/T, T/T) do not seem to influence PNPLA3 in the development of liver steatosis in an Italian cohort with chronic hepatitis C.

2. Targeted next generation DNA sequencing revealed several rare heterozygous missense variants in both MTTP and APOB genes known or predicted to be deleterious, in addition to a novel heterozygous missense variant in SAR1B, which encodes the gene causing chylomicron retention disease

3. Deleterious and protective mutations in MTTP, PNPLA3, and TM6SF2 have been found in Japanese males at risk for non-alcoholic fatty liver disease.

4. The authors conclude that alternate splicing plays a key role in regulating cellular MTP levels by introducing distinct promoter regions and unique 5'-UTRs, which contain elements that alter translation efficiency, enabling the cell to optimize MTP activity.

5. these data reveal clear cellular defects in induced pluripotent stem cells-derived hepatocytes and cardiomyocytes lacking MTTP activity, including a cardiomyocyte-specific regulated stress response to elevated lipids.

6. two new hypolipidemic patients with very low plasma triglyceride and apolipoprotein B (apoB) levels with plasma lipid profiles similar to abetalipoproteinemia (ABL) patients, are reported.

7. results of this study, examining a cohort of obese children, suggest that the genetic variation at MTTP rs2306986 was associated with higher susceptibility to NAFLD

8. Data suggest that amphipathic beta-strands in 200 N-terminal residues of beta1 domain of APOB are required for secretion of lipid-rich or lipid-poor particles; residues 300-700 or 1050-1500 of beta1 domain appear to be required for secretion of lipid-rich particles; MTTP is required for secretion of intact APOB but not of truncated APOB. (APOB = apolipoprotein B; MTTP = microsomal triglyceride transfer protein)

9. In chronic hepatitis C patients infected with HCV genotype 3 and with the TT/GT genotype of the MTTP -493G/T SNP, a significant increase in hepatic steatosis was observed, which may indicate that this SNP has a significant influence on the accumulation of triglycerides in hepatocytes.

10. High expression of MTTP is associated with high carotid intima-media thickness.

11. Its gene mutations are associated with abetalipoproteinemia, developmental delay and hepatic steatosis.

12. MTP Gene Variants are associated with Homozygous Familial Hypercholesterolemia.

13. the N-terminal domain of MTP is important for its lipid transfer activity

14. These studies indicated that SAP18 expression enhanced the recruitment of mSin3A in coordination with TRIB1 to MTTP regulatory elements and increased MTTP expression.

15. Results present evidence that MTTP polymorphisms could modulate the lipid homeostasis to determine the serum lipids and increase risk of non-alcoholic fatty liver disease.

16. Findings from meta-analysis indicate that the MTP -493G/T polymorphism may contribute to the development of non-alcoholic fatty liver disease. Thus, the MTP -493G/T polymorphism may be a biomarker for the early detection of the disease.

17. Homozygous MTTP mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia.

18. MTTP SNPs (GG, GT, TT) and alleles (G, T) in the chronic hepatitis C (genotype 4) patients versus the uninfected controls were 70%, 21%, 9% & 80.5%, 19.5% versus 10%, 87.5%, 2.5% & 53.8%, 46.3%, respectively (p=0.0001).

19. The MTP-493G/T polymorphism modulates postprandial apoB48 and apoB100 of triglyceride-rich lipoproteins in familial combined hyperlipidemia

20. Case Reports: novel mutation in MTTP gene responsible for abetalipoproteinemia in Tunisian families.

Mouse (Murine) Microsomal Triglyceride Transfer Protein (MTTP) interaction partners

1. microsomal triglyceride transfer protein, a protein involved in the transfer of lipids onto CD1d, regulates liver natural killer T cell homeostasis in a manner dependent on hepatocyte CD1d.

2. Microsomal triglyceride transfer protein protein plays a critical role in lipid droplet maturation, but does not regulate total body fat accumulation.

3. data provide the first in vivo evidence of the transcriptional regulatory activity of beta-apocarotenoids and identify microsomal triglyceride transfer protein and its transcription factors as the targets of their action. This study demonstrates that beta-carotene induces a feed-forward mechanism in the placenta to enhance the assimilation of beta-carotene for proper embryogenesis.

4. PHARMACOLOGICAL STUDY OF NEW COMPOUNDS ACTING AS REGULATORS OF 18-KDA TRANSLOCATOR PROTEIN LIGANDS

5. Intestine-specific MTP and global ACAT2 deficiency lowers acute cholesterol absorption with chylomicrons and HDLs

6. intestine-specific Mttp deletion is beneficial in young septic mice but harmful in aged mice

7. identified microsomal triglyceride transfer protein, which we show is also under the transcriptional regulation of C/EBPbeta and -delta, as a novel player in the presentation of endogenous lipid antigens by adipocytes

8. effects of reducing either systemic or liver-specific MTP activity on cholesterol metabolism and reverse cholesterol transport

9. Data show that combined deletion of microsomal triglyceride transfer protein (Mttp) and liver fatty acid binding protein 1 (L-Fabp) are protected from lithogenic diet (LD)-induced gallstone formation.

10. FoxO6 is an important signaling molecule upstream of MTP for regulating hepatic VLDL-TG production

11. intestinal MTP and ABCA1 are critical for lipid absorption and are the main determinants of plasma and intestinal lipid levels.

12. Data indicate that plasma lipids, lipid absorption, and microsomal triglyceride transfer protein (MTP), FoxO1, and FoxA2 levels are lower at night and at mealtime in apoAIV-/- mice.

13. defect causes hepatic insulin resistance selective to hepatic glycogen metabolism

14. MTP inhibition increased transcription of the GPT/GOT1 genes through up-regulation of the IRE1alpha/cJun pathway leading to increased synthesis and release of ALT1/AST1

15. Mttp-IKO mice exhibited protection against sepsis-associated decreases in villus length and intestinal proliferation and were also protected against increased intestinal apoptosis, both central features in control septic mice

16. hepatic LPCAT3 modulates VLDL production by regulating LysoPC levels and MTP expression.

17. LXR agonist treatment caused a paradoxical increase in cholesterol absorption in MTTP-IKO mice and decreased fecal neutral sterol excretion

18. role of Mtp and DGAT2 in hepatic steatosis

19. Data suggest that a peripheral, local gut signaling mechanism involving leptin/leptin receptor B and melanocortin/melanocortin receptor 4 regulates intestinal microsomal triglyceride transfer protein and controls intestinal lipid absorption.

20. distinct changes of MTP expression, in correlation with hepatic triglycerides (TG) secretion, underlie the opposite responses of plasma TG levels to high-fat diets in hamsters and mice.

Fruit Fly (Drosophila melanogaster) Microsomal Triglyceride Transfer Protein (MTTP) interaction partners

1. promotes assembly and secretion of human apolipoprotein B

2. the phospholipid transfer activity of MTP is sufficient for the assembly and secretion of primordial apoB lipoproteins

Cow (Bovine) Microsomal Triglyceride Transfer Protein (MTTP) interaction partners

1. Nonesterified fatty acids significantly inhibit the expression of ApoB100, ApoE, MTP, and LDLR, thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.

2. after calving the apolipoprotein B(100) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP) and apolipoprotein E messenger RNA abundance were higher in the liver

3. measurements of the transfer of phospholipids (PLs) and cholesteryl esters (CEs)to acceptor vesicles by purified MTP showed TAG transfer activity was the most robust, and CE and PL transfer activities were 60-71% and 5-13% of the TAG transfer activity

Pig (Porcine) Microsomal Triglyceride Transfer Protein (MTTP) interaction partners

1. MTTP is regulated by apo A-IV in manner to promote increased packaging of triglyceride into chylomicron core, which may be important in neonatal fat absorption.

2. There appears to be an interaction between the porcine MTTP genotype and the type of fat source in the pig diet, which would agree with the previous results on the biology of MTTP biology.

Zebrafish Microsomal Triglyceride Transfer Protein (MTTP) interaction partners

1. analysis of developmental expression and nutritional regulation of zebrafish homolog to mammalian microsomal triglyceride transfer protein large subunit

2. In a genetic study of lipid transport and metabolism, larval levels of microsomal triglyceride transfer protein (Mtp), the protein responsible for packaging triacylglycerol and beta-lipoproteins into lipoprotein particles, are unchanged by feeding.