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Targeted next generation DNA sequencing revealed several rare heterozygous missense variants in both MTTP and APOB (show APOB Proteins) genes known or predicted to be deleterious, in addition to a novel heterozygous missense variant in SAR1B (show SAR1B Proteins), which encodes the gene causing chylomicron retention disease
Deleterious and protective mutations in MTTP, PNPLA3, and TM6SF2 have been found in Japanese males at risk for non-alcoholic fatty liver disease.
The authors conclude that alternate splicing plays a key role in regulating cellular MTP (show MT1B Proteins) levels by introducing distinct promoter regions and unique 5'-UTRs, which contain elements that alter translation efficiency, enabling the cell to optimize MTP (show MT1B Proteins) activity.
these data reveal clear cellular defects in induced pluripotent stem cells-derived hepatocytes and cardiomyocytes lacking MTTP activity, including a cardiomyocyte-specific regulated stress response to elevated lipids.
two new hypolipidemic patients with very low plasma triglyceride and apolipoprotein B (apoB (show APOB Proteins)) levels with plasma lipid profiles similar to abetalipoproteinemia (ABL (show ABL1 Proteins)) patients, are reported.
results of this study, examining a cohort of obese children, suggest that the genetic variation at MTTP rs2306986 was associated with higher susceptibility to NAFLD
Data suggest that amphipathic beta-strands in 200 N-terminal residues of beta1 domain of APOB (show APOB Proteins) are required for secretion of lipid-rich or lipid-poor particles; residues 300-700 or 1050-1500 of beta1 domain appear to be required for secretion of lipid-rich particles; MTTP is required for secretion of intact APOB (show APOB Proteins) but not of truncated APOB (show APOB Proteins). (APOB (show APOB Proteins) = apolipoprotein B (show APOB Proteins); MTTP = microsomal triglyceride transfer protein)
In chronic hepatitis C patients infected with HCV genotype 3 and with the TT/GT genotype of the MTTP -493G/T SNP, a significant increase in hepatic steatosis was observed, which may indicate that this SNP has a significant influence on the accumulation of triglycerides in hepatocytes.
High expression of MTTP is associated with high carotid intima-media thickness.
MTP (show MT1B Proteins) Gene Variants are associated with Homozygous Familial Hypercholesterolemia.
microsomal triglyceride transfer protein, a protein involved in the transfer of lipids onto CD1d (show CD1D Proteins), regulates liver natural killer T cell homeostasis in a manner dependent on hepatocyte CD1d (show CD1D Proteins).
Microsomal triglyceride transfer protein protein plays a critical role in lipid droplet maturation, but does not regulate total body fat accumulation.
data provide the first in vivo evidence of the transcriptional regulatory activity of beta-apocarotenoids and identify microsomal triglyceride transfer protein and its transcription factors as the targets of their action. This study demonstrates that beta-carotene induces a feed-forward mechanism in the placenta to enhance the assimilation of beta-carotene for proper embryogenesis.
PHARMACOLOGICAL STUDY OF NEW COMPOUNDS ACTING AS REGULATORS OF 18-KDA TRANSLOCATOR PROTEIN (show TSPO Proteins) LIGANDS
Intestine-specific MTP (show LAPTM4A Proteins) and global ACAT2 (show SOAT2 Proteins) deficiency lowers acute cholesterol absorption with chylomicrons and HDLs (show CSF1R Proteins)
intestine-specific Mttp deletion is beneficial in young septic mice but harmful in aged mice
identified microsomal triglyceride transfer protein, which we show is also under the transcriptional regulation of C/EBPbeta (show CEBPB Proteins) and -delta, as a novel player in the presentation of endogenous lipid antigens by adipocytes
effects of reducing either systemic or liver-specific MTP (show LAPTM4A Proteins) activity on cholesterol metabolism and reverse cholesterol transport
Data show that combined deletion of microsomal triglyceride transfer protein (Mttp) and liver fatty acid binding protein 1 (L-Fabp (show FABP1 Proteins)) are protected from lithogenic diet (LD)-induced gallstone formation.
FoxO6 (show Foxo6 Proteins) is an important signaling molecule upstream of MTP (show LAPTM4A Proteins) for regulating hepatic VLDL-TG production
promotes assembly and secretion of human apolipoprotein B (show APOB Proteins)
the phospholipid transfer activity of MTP is sufficient for the assembly and secretion of primordial apoB (show APOB Proteins) lipoproteins
Nonesterified fatty acids significantly inhibit the expression of ApoB100 (show APOB Proteins), ApoE (show APOE Proteins), MTP, and LDLR (show LDLR Proteins), thereby decreasing the synthesis and assembly of VLDL and inducing TG accumulation in bovine hepatocytes.
after calving the apolipoprotein B(100 (show APOB Proteins)) mRNA synthesis was lower, whereas microsomal triglyceride transfer protein (MTP) and apolipoprotein E (show APOE Proteins) messenger RNA abundance were higher in the liver
measurements of the transfer of phospholipids (PLs (show CTSC Proteins)) and cholesteryl esters (CEs)to acceptor vesicles by purified MTP showed TAG transfer activity was the most robust, and CE and PL transfer activities were 60-71% and 5-13% of the TAG transfer activity
MTTP is regulated by apo A-IV in manner to promote increased packaging of triglyceride into chylomicron core, which may be important in neonatal fat absorption.
There appears to be an interaction between the porcine MTTP genotype and the type of fat source in the pig diet, which would agree with the previous results on the biology of MTTP biology.
analysis of developmental expression and nutritional regulation of zebrafish homolog to mammalian microsomal triglyceride transfer protein large subunit
In a genetic study of lipid transport and metabolism, larval levels of microsomal triglyceride transfer protein (Mtp), the protein responsible for packaging triacylglycerol and beta-lipoproteins into lipoprotein particles, are unchanged by feeding.
MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
microsomal triglyceride transfer protein (large polypeptide, 88kDa)
, microsomal triglyceride transfer protein large subunit
, microsomal triglyceride transfer protein B
, microsomal triglyceride transfer protein, large subunit
, microsomal triacylglycerol transfer protein
, microsomal triglyceride transfer protein