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Human S100A9 Protein expressed in Wheat germ - ABIN1319076
Venkataraman, Cole, Svoboda, Pohl, Cole: Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluid. in Journal of immunology (Baltimore, Md. : 1950) 2005
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Human S100A9 Protein expressed in HEK-293 Cells - ABIN2731328
Yeap, Wong, Shimasaki, Teo, Quek, Yong, Diong, Bertoletti, Linn, Wong: CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes. in Scientific reports 2016
In pediatric inflammatory bowel disease treatment groups, a significant inverse association was found between the quality of life and the levels of fecal calprotectin (show S100A8 Proteins).
Fecal calprotectin (show S100A8 Proteins) (FC) was elevated in two-thirds of stool specimens of patients with cystic fibrosis (show S100A8 Proteins) (CF). Increased FC was more common in patients with pancreatic insufficiency. Whether increased FC reflects intestinal inflammation in patients with CF remains to be determined.
In healthy children, 95th Percentile values ranged from 1519 mg/kg at 0 months to 54.4 mg/kg at 144 months for fecal calprotectin (show S100A8 Proteins) (fCP) and from 9.9 mg/kg at 0 months to 0.2 mg/kg at 144 months for fecal eosinophil-derived neurotoxin (show RNASE2 Proteins) (fEDN). There was a significant association between age and fCP concentrations and age and fEDN concentrations and a significant association between fEDN and fCP.
Authors found that downregulation of S100A9 significantly reduced the expression of NF-kappaB (show NFKB1 Proteins), phosphorylation of NF-kappaB (show NFKB1 Proteins) and Bcl-2 (show BCL2 Proteins), as well as the expression of MMP7 (show MMP7 Proteins) and MMP2 (show MMP2 Proteins). Restoration of NF-kappaB (show NFKB1 Proteins) expression sufficiently reversed the inhibitory effects on cell proliferation and invasion induced by S100A9 downregulation in vitro and in vivo.
Urinary NGAL (show LCN2 Proteins) is a good predictor of mortality in established pediatric acute kidney injury (AKI) of heterogeneous etiology and outperforms calprotectin (show S100A8 Proteins) and KIM-1 (show HAVCR1 Proteins). Urinary calprotectin (show S100A8 Proteins) and KIM-1 (show HAVCR1 Proteins) predict renal replacement therapy requirement in pediatric AKI.
Identify proteins that interact with calgranulin B to suppress the proliferation of colon cancer cells.
This study demonstrated that S100A9 was detected in the serums of Alzheimer disease patients
Expression levels of S100A9 and Tenascin-C (show TNC Proteins) were correlated with TNM (show ODZ1 Proteins) stages and metastasis in colorectal cancer.
In Guatemalan preschoolers, the median fecal calprotectin (show S100A8 Proteins) value was 58 mg/kg, with a mean of 98 +/- 136 mg/kg and a range from 10 to 950 mg/kg; 61% of values were above the manufacturer's cut-off for elevated concentration and 51% exceeded an age-adjusted criterion. The central tendency (mean or median) and distribution were generally shifted to the right in relation to comparable reports from children across the world.
Low S100A9 expression is associated with head and neck neoplasms.
Data suggest that up-regulation of S100A8 (show S100A8 Proteins) and S100A9 is a key component of early endometrial response to uterine involution in the post-partum period and to prevent chronic endometritis/uterine inflammation; up-regulation can be influenced by diet.
Study verified porcine calprotectin (S100A8 (show S100A8 Proteins)/A9) expression at the protein level in multiple Haemophilus parasuis infected tissues and explored their molecular characterization.
this study shows that S100A9 inhibits B lymphopoiesis by acting on myeloid cells and promoting the release of inflammatory molecules, including IL-1beta (show IL1B Proteins)
data suggest that S100A8 (show S100A8 Proteins)/A9 acts directly on BV-2 microglial cells via binding to TLR4 (show TLR4 Proteins) and RAGE (show AGER Proteins) on the membrane and then stimulates the secretion of proinflammatory cytokines through ERK (show EPHB2 Proteins) and JNK (show MAPK8 Proteins)-mediated NF-kappaB (show NFKB1 Proteins) activity in BV-2 microglial cells.
Like S100A8 (show S100A8 Proteins), S100A9 and S100A8 (show S100A8 Proteins)/A9 reduced neutrophil influx in acute lung injury provoked by lipopolysaccharide (LPS (show TLR4 Proteins)) challenge.
findings reveal unexpected gene expression differences between WT and KO mice at a young age (in the absence of physiological stress), and address the hypothesis that Mrp8 (show S100A8 Proteins) and Mrp14 accumulation promotes age-related inflammation
S100A8 (show S100A8 Proteins) and S100A9 aggravate Coxsackievirus B3-induced myocarditis and might serve as therapeutic targets in inflammatory cardiomyopathies.
An excessive expansion of monocytic-myeloid-derived suppressor cells in S100A9-/- neonates compared to wild-type neonates. This strong baseline expansion was associated with hyperinflammatory responses during endotoxemia and fatal septic courses
Data support a role of S100A9 to initiate and amplify the neutrophilic inflammation in asthma, possibly via inducing IL-1beta (show IL1B Proteins), IL-17 (show IL17A Proteins) and IFN-gamma (show IFNG Proteins).
The findings show that reduced PTP1B (show PTPN1 Proteins) responses contribute to disease symptoms in part by enhancing S100A9 expression during viral-associated chronic obstructive pulmonary disease exacerbations.
Neutrophil-derived S100A8 (show S100A8 Proteins)/A9 promotes thrombocytosis in diabetic mice
S100A9 knockdown almost completely abrogated the effects of IRF7 (show IRF7 Proteins) deletion on granulocytic myeloid-derived suppressor cells development and tumor metastasis.
Perinatal alarmins S100A8 (show S100A8 Proteins) and S100A9 specifically altered MyD88 (show MYD88 Proteins)-dependent proinflammatory gene programs. S100 programming prevented hyperinflammatory responses without impairing pathogen defense. TRIF (show RNF138 Proteins)-adaptor-dependent regulatory genes remained unaffected by perinatal S100 programming and responded strongly to lipopolysaccharide, but were barely expressed.
Calprotectin (show S100A8 Proteins) expression in laminar epidermis occurs after extravasation of leukocytes indicating that leukocyte emigration may be an initiating factor in laminar epithelial stress and inflammation in black walnut extract-induced laminitis.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis.
, S100 calcium-binding protein A9 (calgranulin B)
, calgranulin B
, calprotectin L1H subunit
, leukocyte L1 complex heavy chain
, migration inhibitory factor-related protein 14
, protein S100-A9
, S100 calcium binding protein A9 (calgranulin B)
, intracellular calcium-binding protein (MRP14)
, myeloid-related protein 14
, protein MRP-126
, S100 calcium binding protein A9
, S100 calcium-binding protein A9
, neutrophil cytosolic 23 kDa protein
, RNA-binding region containing protein 2-like