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Scara5 was downregulated, pointing out this receptor as a potential player implicated in retinopathy and also as a possible therapeutic target.
Defects in fibroblast SCARA5 can underlie some forms of autoimmune disease.
plasma membrane protein SCARA5 can contribute to human hepatocellular carcinoma (HCC (show FAM126A Proteins)) tumorigenesis and metastasis via activation of the FAK (show PTK2 Proteins) signaling pathway.
Tesr is differentially expressed in the male vs. female embryonic and postnatal gonad, and may play a role in phagocytosis of apoptotic cells, cell-cell adhesion, and defense. [Tesr - testis expressed scavenger receptor]
Data show that the transferrin receptor TfR1 provided transferrin (show Tf Proteins) to the ureteric bud, but not to the capsule or the stroma, and that Scara5 bound serum ferritin (show FTL Proteins) and then stimulated its endocytosis from the cell surface with consequent iron delivery.
our data provide a novel evidence for the biological and clinical significance of SPAG5 (show SPAG5 Proteins) as a potential biomarker, and we demonstrate that SPAG5 (show SPAG5 Proteins)-b-catenin-SCARA5 might be a novel pathway involved in hepatocellular carcinoma progression.
SCARA5 may play an important role in tumorigenesis of breast cancer via promoter methylation
The present results provide the first evidence that SCARA5 inhibits lymphangiogenesis by downregulating VEGF-C (show VEGFC Proteins), thereby inhibiting breast cancer lymphatic metastasis.
Knockdown of CSN5 (show COPS5 Proteins) increased SCARA5 expression and inhibited the proliferation and metastasis of HCC (show FAM126A Proteins) cells in vitro and in vivo. Finally, it was found that CSN5 (show COPS5 Proteins) regulated SCARA5 expression by modulating beta-catenin (show CTNNB1 Proteins).
The methylation status of SCARA5 gene are abnormal in Hepatocellular Carcinoma patients, which may further be used as molecular markers for early diagnosis of Liver cancer.
Taken together, these results suggest that this newly identified Rock2 (show ROCK2 Proteins)-beta-catenin (show CTNNB1 Proteins)/TCF4 (show TCF4 Proteins)-SCARA5 axis will provide novel insight into the understanding of the regulatory mechanisms of proliferation in human RCC (show XRCC1 Proteins).
SCARA5 and SBSN shown to have modest effects on cell proliferation or collagen gel contraction and maybe associated with peripheral vein graft patency.
this study demonstrated that knockdown of SCARA5 inhibits PDGFBBinduced HASMC proliferation and migration through suppression of the PDGF (show PDGFA Proteins) signaling pathway.
The overexpression of SCARA5 significantly inhibited the proliferation, colony formation and migration/invasion abilities of osteosarcoma cells.
SCARA5 is an HMGB1 (show HMGB1 Proteins) recognition receptor that is negatively involved in HMGB1 (show HMGB1 Proteins)-mediated inflammation in pufferfish (Tetraodon nigroviridis) and zebrafish (Danio rerio) models.
Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1) (By similarity).
scavenger receptor class A member 5
, testis expressed scavenger receptor
, scavenger receptor hlg
, scavenger receptor class A, member 5