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anti-Human SLC30A4 Antibodies:
anti-Mouse (Murine) SLC30A4 Antibodies:
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There was a significant increase in protein levels of ZnT4 in the prefrontal cortex in Major depression disorder, relative to control subjects.
TRPML1 (show MCOLN1 Antibodies) works in concert with ZnT4 to regulate zinc translocation between the cytoplasm and lysosomes.
The loss of ZnT4 in airway inflammation contributes to airway epithelium vulnerability in diseases such as asthma.
our results suggest that alterations in Zn transport proteins ZnT-1 (show SLC30A1 Antibodies), ZnT-4 and ZnT-6 (show SLC30A6 Antibodies) may contribute to the pathology observed in preclinical Alzheimer's disease subjects before onset of clinical symptoms
decreased intensity of ZnT4 immunoreactivity occurred in the progression from benign to invasive localized prostate cancer and to metastatic disease
findings implicate a role for ZnT(4) in mast cell Zn homeostasis and suggest that granule pools of Zn may be distinct from those regulating activation of procaspase-3 and NF-kappaB (show NFKB1 Antibodies).
Data show that ZNT4 is extensively present in the Abeta (show APP Antibodies)-positive plaques in the cortex of human AD brains.
Loss of ZnT4 has profound consequences on mammary epithelial cell secretion and may promote tissue remodeling in the mammary gland during early lactation.
It was shown that that ZnT4 transports Zn into the trans-Golgi network, which is critical for key secretory functions of the mammary cell.
Expression of zinc transporter ZnT4 in mouse choroid epithelial cells suggests that the choroid plexus plays an important role in regulation of zinc homeostasis in the brain.
Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997
solute carrier family 30 member 4
, zinc transporter 4
, solute carrier family 30 (zinc transporter), member 4
, zinc transporter 4-like
, lethal milk protein
, solute carrier family 30 (zinc transporter), member 4; zinc transporter 4
, Dri 27/ZnT4 protein
, dri 27 protein