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anti-Human CTHRC1 Antibodies:
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Human Monoclonal CTHRC1 Primary Antibody for IHC (p), ELISA - ABIN530367
Kim, Baek, Yim, Kim, Jeong, Kang, Oh, Lee, Kim, Kim: Collagen triple helix repeat containing-1 (CTHRC1) expression in invasive ductal carcinoma of the breast: the impact on prognosis and correlation to clinicopathologic features. in Pathology oncology research : POR 2013
Study revealed that CTHRC1 promoted HeLa cell progression by activating the Wnt/PCP signaling pathway and may play a key role in the invasion and metastasis of cervical carcinoma.
Cthrc1 may play a role in the pathogenesis of keloid by inhibiting collagen synthesis and fibroblasts migration via suppressing TGF-b/Smad pathway and YAP nucleus translocation
CTHRC1 probably plays an important part in the pathogenesis of systemic lupus erythematosus (SLE), and is positively associated with disease activity, while it also likely refers to the development of arthritis and anemia in SLE
CTHRC1 serves as a pro-metastatic gene that contributes to NSCLC invasion and metastasis, which are mediated by upregulated MMP7 and MMP9 expression. Targeting CTHRC1 may be beneficial for inhibiting NSCLC metastasis.
High Collagen Triple Helix Repeat Containing 1 Expression is associated with Osteosarcoma.
E6/E7-p53-POU2F1-CTHRC1 axis promotes cervical cancer cell invasion and metastasis
IL-1beta and CTHRC1 are upregulated in patients with Osteoarthritis.
CTHRC1 interacts with integrin beta3 and accelerates the FAK phosphorylation to promote ovarian cancer cell adhesion, migration and invasion in vitro and in vivo.
CTHRC1 plays a pivotal role in a great many fields, including increases bone mass, prevents myelination, reverses collagen synthesis in keloid fibroblasts, and increases fibroblast-like synoviocytes migration speed and abundant production of arthritic pannus in rheumatoid arthritis
CTHRC1, negatively regulated by miR-30c, promoted cell proliferation, invasion and migration and suppressed cell apoptosis in breast cancer, which might be by activating GSK-3beta/beta-catenin signaling and inhibiting Bax/Caspase-9/Caspase-3 signaling respectively.
Our data suggest that CTHRC1 may act as an oncogenic driver in progression and metastasis of ESCC, and may serve as a potential biomarker for prognosis and personalized therapy.
The negative and sensitivity-predictive values of CTHRC1 staining were excellent for both lymph node and peritoneal metastases.
High CTHRC1 expression is associated with metastatic melanomas.
CTHRC1 was established as a novel marker of activated synoviocytes in murine experimental arthritis and rheumatoid arthritis
ANOS1 and its co-expression partner, CTHRC1, promote the development and metastasis of colorectal cancer.
Expression of CTHRC1 was significantly higher in Wilms' tumor compared to the expression in the adjacent non-cancerous tissues. High tumor expression of CTHRC1 was associated with tumor size, clinical stage, histopathological type, and vascular invasion/metastasis. Patients with high CTHRC1 expression also exhibited a shorter survival.
CTHRC1 expression is significantly upregulated in human masticatory mucosa during wound healing.
CTHRC1 downregulation inhibited proliferation.
The knockdown of CTHRC1 exerts inhibitory effects on the proliferation and migration ability of glioblastoma cells.
CTHRC1 may play a role in the progression of ovarian cancer.
CTHRC1 secreted from osteocytes and osteoblasts functions as an inhibitor of osteoclast differentiation via inhibition of NFkappaB-dependent signaling.
These data suggest Cthrc1 reduces fibrotic tissue formation in bleomycin-induced lung fibrosis and the effect is potent enough to limit the decline in lung function.
CTHRC1 is an osteoclast-secreted coupling factor that regulates bone remodeling.
This study demonstrated that Cthrc1 plays a negative regulatory role, fine-tuning the onset of peripheral myelination.
this is the first demonstration of Cthrc1 as a marker of the severity of the disease progression in the dystrophic muscles.
Hormonal functions of Cthrc1 include regulation of lipid storage and cellular glycogen levels with potentially broad implications for cell metabolism and physiology.
Data show a dramatic discrepancy between ROSA26 reporter activity and Pdgfrb promoter driven Cre dependent myc-tagged Cthrc1 transgene expression.
Downregulated by dietary beta-carotene in lungs of knockout Bcmo1-deficient mice.
Cthrc1 expression overlaps considerably with those reported for TGF-beta family members and interstitial collagens.
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.
Cthrc1 increases bone mass as a positive regulator of osteoblastic bone formation
This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described.
collagen triple helix repeat containing 1
, collagen triple helix repeat-containing protein 1