Browse our anti-LHX2 (LHX2) Antibodies

Human LIM Homeobox 2 (LHX2) interaction partners

1. MiR-506 inhibits tumor growth and metastasis in NPC via inhibition of Wnt/beta-catenin signaling by down-regulating LHX2.

2. These data indicate that Lhx2 is capable of blocking proliferation of T-ALL-derived cells by both LMO2-dependent and -independent means. We propose Lhx2 as a new molecular tool for anti-T-ALL drug development.

3. Findings demonstrate that miR-1238 inhibit the proliferation of NSCLC cells at least partly via repression of LHX2, shedding light on the mechanistic interaction of miR-1238 and LHX2 in NSCLC carcinogenesis.

4. Results show that LHX2 is overexpressed in pancreatic ductal adenocarcinoma cells and is involved in promoting cancer cell proliferation and enhanced tumor development.

5. Lhx2 directly regulates tanycyte specification and differentiation in the hypothalamus.

6. This study demonistrated that LHx2 regulates the development of the forebrain hem system.

7. The data indicate a dual role of Lhx2 during EMT and tumor progression: by inducing the expression of PDGF-B, Lhx2 provokes an autocrine PDGF-B/PDGFRbeta loop required for cell migration, invasion and metastatic dissemination

8. The findings indicate that LHX2 regulates the transcription of downstream intrinsic and extrinsic molecules that are essential for early neural differentiation.

9. These results suggest that if LHX2 is involved in pituitary hormone deficiency associated with posterior pituitary and ocular defects, it would be a rare cause of this disease condition.

10. Mutations in LHX2 do not represent a frequent cause of micro/anophthalmia.

11. A large cohort of patients with schizencephaly, some with features of septo-optic dysplasia, were sequenced for mutations in LHX2, HESX1 and SOX2.

Zebrafish LIM Homeobox 2 (LHX2) interaction partners

1. Lack of Lhx2/Lhx9 function as well as increased Wnt signaling alter the expression of the thalamus specific cell adhesion factor pcdh10b and lead subsequently to a striking anterior-posterior disorganization of the caudal forebrain.

2. Lhx2 may mediate an alternative or parallel pathway for control of cellular proliferation in the developing forebrain via Six3.

3. required for patterning in the ventral forebrain and eye.

Mouse (Murine) LIM Homeobox 2 (LHX2) interaction partners

1. Greek-island-bound transcription factor LHX2 and adaptor protein LDB1 regulate the assembly and maintenance of olfactory receptor compartments, Greek island hubs and olfactory receptor transcription, providing mechanistic insights into and functional support for the role of trans interactions in gene expression

2. PAX6 can substitute for LHX2 and override NFIA-induced astrogliogenesis in developing hippocampus in vivo.

3. The central role of Lhx2 in organizing and coordinating Muller glia retinal differentiation.

4. these results not only reveal a novel function for LHX2 in regulating dorsoventral patterning in the telencephalon, but also identify PAX6 as a fundamental regulator of where the hem can form, and therefore implicate this molecule as a determinant of hippocampal positioning.

5. The authors show that transcription factors Lhx2 and Ebf specify olfactory receptor enhancers by binding in a functionally cooperative fashion to stereotypically spaced motifs that defy heterochromatin.

6. These findings show that control of Lhx2 function by Ldb1 and Rnf12 underpins the coordinated differentiation of neurons and Muller glia in postnatal retina.

7. Foxg1 and Lhx2 form a genetic hierarchy in the spatiotemporal regulation of cortical hem specification and positioning, and together ensure the normal development of this hippocampal organizer.

8. LIM homeobox protein 2 confers neuronal competency for activity-dependent dendritic development in L4 neurons by inducing the expression of BTB domain containing 3.

9. Lhx2 regulates Dmrt5: loss of either factor promotes gliogenesis and overexpression of either factor promotes neurogenesis.

10. Neuroretinal expression of Lhx2 and neuroretina-derived FGF factors are crucial for lens fiber development in vivo.

11. LHX2 is a key component of the control network for producing neurons that will participate in cortical circuitry

12. We found that expression of Emx2 and Lhx2 initiated between neuronal progenitor and neuronal precursor stages. As far as the sensory neurons of the vomeronasal organ are concerned, Meis1 and Meis2 were only expressed in the apical layer, together with Gnai2, but not in the basal layer.

13. Lhx2 is required for maintenance of the corneal epithelial cell compartment and the limbal barrier.

14. The ectopic expression of Lhx2 in OP9 cells (OP9-Lhx2) accelerates the hematopoietic differentiation of PSCs.

15. Conditional knock-out of Lhx2 resulted in down-regulation of Notch pathway genes in retinal glia.

16. These studies define essential roles for Lhx2 in glial wedge, hippocampal commissure, and corpus callosum formation, and suggest that defects in radial glial wedge progenitors can give rise to corpus callosum.

17. CTIP2 transcription factor maintains stem cells in hair follicle and alters LHX2 expression.

18. Lhx2 regulates the timing of beta-catenin-dependent cortical neurogenesis.

19. Lhx2 controls neocortical area patterning by regulating downstream genetic and epigenetic regulators that drive the acquisition of molecular properties in cortical plate neurons.

20. Lhx2 acts as a negative regulator of osteoclast formation in vitro and in vivo.

Pig (Porcine) LIM Homeobox 2 (LHX2) interaction partners

1. Lhx2 expression during porcine fetal and postnatal pituitary development showed a gradual increase from fetal day (f) 40 to postnatal day (p) 8 followed by a slight decrease to p230.