Browse our anti-LHX2 (LHX2) Antibodies

Human LIM Homeobox 2 (LHX2) interaction partners

1. These data indicate that Lhx2 is capable of blocking proliferation of T-ALL-derived cells by both LMO2 (show LMO2 Antibodies)-dependent and -independent means. We propose Lhx2 as a new molecular tool for anti-T-ALL drug development.

2. Findings demonstrate that miR (show MLXIP Antibodies)-1238 inhibit the proliferation of NSCLC cells at least partly via repression of LHX2, shedding light on the mechanistic interaction of miR (show MLXIP Antibodies)-1238 and LHX2 in NSCLC carcinogenesis.

3. Results show that LHX2 is overexpressed in pancreatic ductal adenocarcinoma cells and is involved in promoting cancer cell proliferation and enhanced tumor development.

4. Lhx2 directly regulates tanycyte specification and differentiation in the hypothalamus.

5. This study demonistrated that LHx2 regulates the development of the forebrain hem system.

6. The data indicate a dual role of Lhx2 during EMT (show ITK Antibodies) and tumor progression: by inducing the expression of PDGF-B (show PDGFB Antibodies), Lhx2 provokes an autocrine PDGF-B (show PDGFB Antibodies)/PDGFRbeta loop required for cell migration, invasion and metastatic dissemination

7. The findings indicate that LHX2 regulates the transcription of downstream intrinsic and extrinsic molecules that are essential for early neural differentiation.

8. These results suggest that if LHX2 is involved in pituitary hormone (show CGA Antibodies) deficiency associated with posterior pituitary and ocular defects, it would be a rare cause of this disease condition.

9. Mutations in LHX2 do not represent a frequent cause of micro/anophthalmia.

10. A large cohort of patients with schizencephaly, some with features of septo-optic dysplasia, were sequenced for mutations in LHX2, HESX1 (show HESX1 Antibodies) and SOX2 (show SOX2 Antibodies).

Zebrafish LIM Homeobox 2 (LHX2) interaction partners

1. Lack of Lhx2/Lhx9 (show LHX9 Antibodies) function as well as increased Wnt (show WNT2 Antibodies) signaling alter the expression of the thalamus specific cell adhesion factor pcdh10b and lead subsequently to a striking anterior-posterior disorganization of the caudal (show CAD Antibodies) forebrain.

2. Lhx2 may mediate an alternative or parallel pathway for control of cellular proliferation in the developing forebrain via Six3.

Mouse (Murine) LIM Homeobox 2 (LHX2) interaction partners

1. PAX6 (show PAX6 Antibodies) can substitute for LHX2 and override NFIA (show NFIA Antibodies)-induced astrogliogenesis in developing hippocampus in vivo.

2. The central role of Lhx2 in organizing and coordinating Muller glia retinal differentiation.

3. these results not only reveal a novel function for LHX2 in regulating dorsoventral patterning in the telencephalon, but also identify PAX6 (show PAX6 Antibodies) as a fundamental regulator of where the hem can form, and therefore implicate this molecule as a determinant of hippocampal positioning.

4. The authors show that transcription factors Lhx2 and Ebf specify olfactory receptor enhancers by binding in a functionally cooperative fashion to stereotypically spaced motifs that defy heterochromatin.

5. These findings show that control of Lhx2 function by Ldb1 (show LDB1 Antibodies) and Rnf12 (show RLIM Antibodies) underpins the coordinated differentiation of neurons and Muller glia in postnatal retina.

6. Foxg1 (show FOXG1 Antibodies) and Lhx2 form a genetic hierarchy in the spatiotemporal regulation of cortical hem specification and positioning, and together ensure the normal development of this hippocampal organizer.

7. LIM homeobox protein 2 confers neuronal competency for activity-dependent dendritic development in L4 neurons by inducing the expression of BTB domain containing 3.

8. Lhx2 regulates Dmrt5 (show DMRTA2 Antibodies): loss of either factor promotes gliogenesis and overexpression of either factor promotes neurogenesis.

9. Neuroretinal expression of Lhx2 and neuroretina-derived FGF factors are crucial for lens fiber development in vivo.

10. LHX2 is a key component of the control network for producing neurons that will participate in cortical circuitry

Pig (Porcine) LIM Homeobox 2 (LHX2) interaction partners

1. Lhx2 expression during porcine fetal and postnatal pituitary development showed a gradual increase from fetal day (f) 40 to postnatal day (p) 8 followed by a slight decrease to p230 (show TNC Antibodies).