Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human STK3 Antibodies:
anti-Mouse (Murine) STK3 Antibodies:
anti-Rat (Rattus) STK3 Antibodies:
Go to our pre-filtered search.
Human Polyclonal STK3 Primary Antibody for IHC (p), WB - ABIN6243888
Zi, Maqsood, Prehar, Mohamed, Abou-Leisa, Robertson, Cartwright, Ray, Oh, Lim, Neyses, Oceandy: The mammalian Ste20-like kinase 2 (Mst2) modulates stress-induced cardiac hypertrophy. in The Journal of biological chemistry 2015
Integration analysis of esophageal squamous cell carcinoma (ESCC) identified five hyper-methylated CpG sites in STK3, ZNF418 and ZNF542 that can be used for effective methylation-based testing for ESCC diagnosis.
High MST2 expression is associated with malignant melanoma.
Here, the authors discover SAV1 (show SAV1 Antibodies)-mediated inhibition of the PP2A (show PPP2R4 Antibodies) complex STRIPAK(SLMAP (show SLMAP Antibodies)) as a key mechanism of MST1 (show MST1 Antibodies)/2 activation.
Through a comprehensive set of biochemical, biophysical, mutational and structural studies, we quantitatively assess how phosphorylation of MOB1A (show MOBKL1B Antibodies) regulates its interaction with both MST (show MAP3K10 Antibodies) kinases and LATS/NDR (show STK38 Antibodies) family kinases in vitro.
In this study, we investigated the mechanisms behind the recruitment of MST1 and MST2 kinases to MOB1, which facilitate signal transmission in the Hippo pathway by bringing the MST1 and MST2 kinases in close vicinity to their substrates, the LATS family kinases.
Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1 (show MST1 Antibodies)/2)/YAP (show YAP1 Antibodies) signaling, and that inhibition of miR (show MLXIP Antibodies)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 (show SOX2 Antibodies) and SALL4 (show SALL4 Antibodies).
These findings reveal a novel layer of regulation for MST2 in mitosis and its role in tumorigenesis.
TNFAIP8 regulates Hippo (MST1/2) signaling through its interaction with LATS1.
Data suggest that Hippo (MST1 (show MST1 Antibodies)/2 protein kinases) - Yes associated protein 1 (YAP (show YAP1 Antibodies)) pathway involved in carcinogenesis of pancreatic cancer and in the inhibition effect of stiehopus japonieus acidic mucopolysaccharide (SJAMP) to the proliferation of pancreatic cancer cell.
H-ras (show HRAS Antibodies), via an Erk (show EPHB2 Antibodies)-dependent mechanism, downregulates Mst1 (show MST1 Antibodies)/Mst2 activity by inducing the formation of inactive Mst1 (show MST1 Antibodies)/Mst2 heterodimers.
findings identify Mst1 (show MST1 Antibodies)/2 as selective drivers of CD8alpha(+) dendritic cell function by integrating metabolic activity and cytokine signalling, and highlight that the interplay between immune signalling and metabolic reprogramming underlies the unique functions of dendritic cell subsets
It is involved in apoptosis and serine/threonine kinase 3 (STK3 (show PKN1 Antibodies)) is a recently identified caspase-6 (show CASP6 Antibodies) substrate.
Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 (show MST1 Antibodies) and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (show YAP1 Antibodies) target genes and hepatocyte proliferation.
Studies indicate that Hippo (Hpo (show GFER Antibodies); MST1 (show MST1 Antibodies)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Mst2 is involved in bone homeostasis, functioning as a reciprocal regulator of osteoclast and osteoblast differentiation through the NF-kappaB (show NFKB1 Antibodies) pathway
the TLR-Mst1 (show MST1 Antibodies)-Mst2-Rac (show AKT1 Antibodies) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
These data indicate that that inhibition of mammalian sterile 20-like kinase 1 (show STK4 Antibodies) rescued cardiac fibrosis and myocardial dysfunction in chronic beta1-adrenergic receptor stimulation-induced cardiomyopathy
Phosphorylation of LC3 (show MAP1LC3A Antibodies) by the STK3 (show PKN1 Antibodies) and STK4 is essential for autophagy.
These results identify MST2, not MST1 (show MST1 Antibodies), as a critical regulator of caspase (show CASP3 Antibodies)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
results reveal a novel role of Mst2 in stress-dependent cardiac hypertrophy and remodeling in the adult mouse and likely human heart
This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, STE20-like kinase MST2
, mammalian STE20-like protein kinase 2
, serine/threonine kinase 3 (STE20 homolog, yeast)
, serine/threonine kinase 3 (Ste20, yeast homolog)
, serine/threonine-protein kinase 3
, serine/threonine-protein kinase Krs-1
, protein kinase homolog
, serine/threonine kinase 3 (STE20 homolog)