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Through a comprehensive set of biochemical, biophysical, mutational and structural studies, we quantitatively assess how phosphorylation of MOB1A (show MOBKL1B Proteins) regulates its interaction with both MST (show MAP3K10 Proteins) kinases and LATS/NDR (show STK38 Proteins) family kinases in vitro.
In this study, we investigated the mechanisms behind the recruitment of MST1 and MST2 kinases to MOB1, which facilitate signal transmission in the Hippo pathway by bringing the MST1 and MST2 kinases in close vicinity to their substrates, the LATS family kinases.
Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1 (show MST1 Proteins)/2)/YAP (show YAP1 Proteins) signaling, and that inhibition of miR (show MLXIP Proteins)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 (show SOX2 Proteins) and SALL4 (show SALL4 Proteins).
TNFAIP8 regulates Hippo (MST1/2) signaling through its interaction with LATS1.
Data suggest that Hippo (MST1 (show MST1 Proteins)/2 protein kinases) - Yes associated protein 1 (YAP (show YAP1 Proteins)) pathway involved in carcinogenesis of pancreatic cancer and in the inhibition effect of stiehopus japonieus acidic mucopolysaccharide (SJAMP) to the proliferation of pancreatic cancer cell.
our results identified that mammalian sterile 20-like kinase 1 is a novel downstream target of pyruvate kinase M2, and knockdown of pyruvate kinase M2 contributes apoptosis via promoting nuclear translocation of mammalian sterile 20-like kinase 1 by enhancing Caspase-3 (show CASP3 Proteins)-dependent cleavage.
H-ras (show HRAS Proteins), via an Erk (show EPHB2 Proteins)-dependent mechanism, downregulates Mst1 (show MST1 Proteins)/Mst2 (show STK3 Proteins) activity by inducing the formation of inactive Mst1 (show MST1 Proteins)/Mst2 (show STK3 Proteins) heterodimers.
Mst1 (show MST1 Proteins) as a novel physiological negative regulator of IRF3 (show IRF3 Proteins) activation provides mechanistic insights into innate antiviral defense and potential antiviral prevention strategies.
Data indicate that two siblings with a serine/threonine kinase 4 (STK4) mutation with features of autosomal recessive (AR) hyperimmunoglobulin E syndrome and autoimmune cytopenias.
STK4 was reduced in macrophages from human hepatoma patients and was inversely associated with the levels of IRAK1, IL-6, and phospho-p65 or phospho-STAT3. Serum STK4 levels were specifically decreased in HCC patients with high levels of IL-6.
the present study demonstrated that deletion of Mst1 (show MST1 Proteins) attenuated neuronal loss and improved locomotor function in a mouse model of spinal cord injury, via preserving mitochondrial function, attenuating mitochondria-mediated apoptotic pathway, and suppressing inflammation, at least in part.
Mst1 (show MST1 Proteins) deficiency promotes post-traumatic spinal motor neuron survival via enhancement of autophagy flux.
mammalian sterile 20-like kinase 1 (Mst1) knockout abolished the protective effects of Luteolin administration in a mouse model of myocardial infarction.
Studies indicate that Hippo (Hpo (show GFER Proteins); MST1 (show MST1 Proteins)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Data (including data from studies in knockout/transgenic mice) suggest Mst1 (show MST1 Proteins) has functional roles in cytotoxic T-lymphocytes and in inhibition of tumor progression/size of T-cell lymphoma; Mst1 (show MST1 Proteins) may be involved in tumor immunity/immunologic surveillance.
the TLR-Mst1 (show MST1 Proteins)-Mst2 (show STK3 Proteins)-Rac (show AKT1 Proteins) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
Macrophage-specific Stk4 deletion resulted in chronic inflammation, liver fibrosis, and hepatomas in mice exposed to liver insult.
STK4 is a novel candidate biomarker for early stage pancreatic cancer.
Phosphorylation of LC3 (show MAP1LC3A Proteins) by the STK3 (show PKN1 Proteins) and STK4 is essential for autophagy.
These results identify MST2 (show STK3 Proteins), not MST1 (show MST1 Proteins), as a critical regulator of caspase (show CASP3 Proteins)-mediated photoreceptor cell death in the detached retina and indicate its potential as a future neuroprotection target.
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
, STE20-like kinase MST1
, dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))
, kinase responsive to stress 2
, mammalian STE20-like protein kinase 1
, mammalian sterile 20-like 1
, serine/threonine-protein kinase 4
, serine/threonine-protein kinase Krs-2
, Yeast Sps1/Ste20-related kinase 3
, sterile 20-like kinase 1