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hWW45 (show SAV1 Proteins) is required to enhance MST1 (show MST1 Proteins)-mediated apoptosis in vivo and thus is a critical player in an MST1 (show MST1 Proteins)-driven cell death signaling pathway.
MST1 (show MST1 Proteins)-FOXO1 (show FOXO1 Proteins) signaling is an important link survival factor deprivation-induced neuronal cell death
hSav1 is a newly identified protein that interacts with Mst1 (show MST1 Proteins) and augments Mst1 (show MST1 Proteins)-mediated apoptosis.
tolerance to increased levels of intracellular ROS (show ROS1 Proteins) provided by the Mst1 (show MST1 Proteins)-FoxOs signaling pathway is crucial for the maintenance of naive T cell homeostasis in the periphery
The identified Mst1 (show MST1 Proteins) as a binding partner that interacts with PHLPPs both in vivo and in vitro. PHLPPs dephosphorylate Mst1 (show MST1 Proteins) on the T387 inhibitory site, which activate Mst1 (show MST1 Proteins) and its downstream effectors p38 (show CRK Proteins) and JNK (show MAPK8 Proteins) to induce apoptosis.
H2AX (show H2AFX Proteins) is a substrate of MST1 (show MST1 Proteins), which functions to induce apoptotic chromatin condensation and DNA fragmentation
novel regulatory mechanism involving the phosphorylation of Sirt1 (show SIRT1 Proteins) by MST1 (show MST1 Proteins) kinase which leads to p53 (show TP53 Proteins) activation, with implications for our understanding of signaling mechanisms during DNA damage-induced apoptosis
Mst1 (show MST1 Proteins) exhibits a growth promoting activity (show CNTF Proteins) in HCC (show FAM126A Proteins) cells upon NORE1B (show RASSF5 Proteins) downregulation.
Mst1 (show MST1 Proteins) inactivates Prdx1 (show PRDX1 Proteins) by phosphorylating it at Thr (show TRH Proteins)-90 and Thr (show TRH Proteins)-183, leading to accumulation of hydrogen peroxide in cells.
results suggest that Mst1 (show MST1 Proteins) coordinately regulates autophagy and apoptosis by phosphorylating Beclin1 (show BECN1 Proteins) and consequently modulating a three-way interaction among Bcl-2 (show BCL2 Proteins) proteins, Beclin1 (show BECN1 Proteins) and Bax (show BAX Proteins)
NDR1 (show STK38 Proteins) kinase, activated by the Rap1 (show TERF2IP Proteins) signaling cascade through RAPL (show RASSF5 Proteins) and Mst1 (show MST1 Proteins)/Mst2 (show STK3 Proteins), associated with and recruited kindlin-3 (show FERMT3 Proteins) to the immunological synapses, which was required for high-affinity LFA-1 (show ITGAL Proteins)/ICAM-1 (show ICAM1 Proteins) binding.[Kindlin-3 (show FERMT3 Proteins)]
the present study demonstrated that deletion of Mst1 (show MST1 Proteins) attenuated neuronal loss and improved locomotor function in a mouse model of spinal cord injury, via preserving mitochondrial function, attenuating mitochondria-mediated apoptotic pathway, and suppressing inflammation, at least in part.
Mst1 (show MST1 Proteins) deficiency promotes post-traumatic spinal motor neuron survival via enhancement of autophagy flux.
mammalian sterile 20-like kinase 1 (Mst1) knockout abolished the protective effects of Luteolin administration in a mouse model of myocardial infarction.
Studies indicate that Hippo (Hpo (show GFER Proteins); MST1 (show MST1 Proteins)/2 in mammals) signaling pathway plays a central role in the cell fate-specification process.
Data (including data from studies in knockout/transgenic mice) suggest Mst1 (show MST1 Proteins) has functional roles in cytotoxic T-lymphocytes and in inhibition of tumor progression/size of T-cell lymphoma; Mst1 (show MST1 Proteins) may be involved in tumor immunity/immunologic surveillance.
the TLR-Mst1 (show MST1 Proteins)-Mst2 (show STK3 Proteins)-Rac (show AKT1 Proteins) signaling axis is critical for effective phagosome-mitochondrion function and bactericidal activity
Macrophage-specific Stk4 deletion resulted in chronic inflammation, liver fibrosis, and hepatomas in mice exposed to liver insult.
STK4 is a novel candidate biomarker for early stage pancreatic cancer.
Phosphorylation of LC3 (show MAP1LC3A Proteins) by the STK3 (show PKN1 Proteins) and STK4 is essential for autophagy.
The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process.
, STE20-like kinase MST1
, dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))
, kinase responsive to stress 2
, mammalian STE20-like protein kinase 1
, mammalian sterile 20-like 1
, serine/threonine-protein kinase 4
, serine/threonine-protein kinase Krs-2
, Yeast Sps1/Ste20-related kinase 3
, sterile 20-like kinase 1