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the studies confirm the extent of ZIC2 allelic heterogeneity and that pathogenic variants of ZIC2 are associated with both classic and middle interhemispheric variant (MIHV) HPE which arise from defective ventral and dorsal forebrain patterning, respectively.
miR (show MLXIP Proteins)-1271/Zic2/PAK4 (show PAK4 Proteins) axis plays an important role in hepatocellular carcinoma progression.
Together SMAD3 (show SMAD3 Proteins) and ZIC2 regulate FOXA2 (show FOXA2 Proteins) transcription in cultured cells and Zic2 also controls the foxA2 (show FOXA2 Proteins) expression during Xenopus development. These findings reveal a new mechanism of NODAL signal transduction in the mammalian node and provide the first molecular explanation of how ZIC2 loss-of-function precipitates Holoprosencephaly (HPE
Data show that Zinc finger protein ZIC 2 (ZIC2) is indispensable in the regulation of pancreatic ductal adenocarcinoma (PDAC) cell apoptosis.
ZIC2 acts upstream of OCT4 (show POU5F1 Proteins) and recruits the nuclear remodeling factor complex to the OCT4 (show POU5F1 Proteins) promoter, initiating OCT4 (show POU5F1 Proteins) activation. ZIC2 levels positively correlated to the clinicopathological stages of HCC (show FAM126A Proteins) patients.
Mutational screening for HPE genes revealed the occurrence of a frameshift mutation in the ZIC2 gene.
ZIC2 and RASGRF1 (show RASGRF1 Proteins) are susceptibility genes, not only for common myopia, but also for high myopia.
The c.1401_1406dup (p.Ala469_470dup) or alanine tract expansion to 17 residues) in the ZIC2 gene are likely to be medically significant for holoprosencephaly in a Brazilian cohort.
A high level of sequence variation in the 3'UTR of ZIC2 may be associated with holoprosencephaly.
ZIC2, a transcription factor related to the sonic hedgehog (show SHH Proteins) pathway, is a strong discriminant between MAL and LMP (show PDLIM7 Proteins) tumors: it may be a major determinant of outcome of EOTs.
these data establish zic2 mutant zebrafish as a powerful new genetic model for in-depth dissection of cell interactions and genetic controls during craniofacial complex development.
Zic2a and Zic2b play a dual role during craniofacial development, in neural crest induction and migration, and in craniofacial chondrogenesis patterning
Zic2a and Zic5 have essential, cooperative roles in promoting cell proliferation in the tectum, but lack obvious patterning functions.
the results identify Zic2a as a novel regulator of prethalamic development, and show that it functions independently of hedgehog (show SHH Proteins) signaling.
Zic2a and zic5 as crucial players in the genetic network linking patterned gene expression to morphogenetic changes during neurulation.
These data uncover a novel, essential role for Zic2a as a modulator of Hedgehog (show SHH Proteins)-activated gene expression in the developing forebrain
The major acting transcription factors shift from SOX2 (show SOX2 Proteins)/POU5F1 (show POU5F1 Proteins) in mouse ESCs (show NR2E3 Proteins) to ZIC2/OTX2 (show OTX2 Proteins) in EpiSCs, and this shift is primed in ESCs (show NR2E3 Proteins) by binding of ZIC2 at relevant genomic positions that later function as enhancers.
Zic2 and Zic1 (show ZIC1 Proteins) proteins are essential to control the balance between two defined neuron types in the postnatal forebrain.
This shift in the major acting transcription factors appears to be primed by binding of ZIC2 in embryonic stem cells at relevant genomic positions.
Here, we reveal a previously unknown role for Zic2 in the migration of forebrain neurons such as Cajal-Retzius cells, interneurons moving to the ventral lateral geniculate nucleus, and neocortical cells going to the amygdala.
Zic1 (show ZIC1 Proteins) and Zic2 are required for coordinating mature neuronal gene expression patterns.
Zic2 loss-of-function doesn't prevent initial otocyst patterning but leads to molecular abnormalities concomitant with morphogenesis of the endolymphatic duct.
Zic2 is a key factor in the execution of transcriptional fine-tuning with Mbd3 (show MBD3 Proteins)/NuRD in embryonic stem cells through interactions with enhancers.
Zic2 appears to be a component of the gene regulatory network that drives ciliation of node cells during gastrulation.
results reveal a Zic2-dependent mechanism, shared by different neural populations, essential to prevent midline crossing during the development of the nervous system.
Explant culture of Zic2(m1Nisw) gastrointestinal tract show extensive neurite outgrowth, suggesting that Zic2 is a negative regulator of nerve fiber growth.
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
Zic family member 2 (odd-paired homolog, Drosophila)
, Zinc finger protein of the cerebellum 2
, zinc finger protein ZIC 2
, cerebellum zinc finger protein 2
, zinc finger protein of the cerebellum 2
, zinc finger cerebellum 2
, GENA 29
, odd-paired homolog