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Results show that ZIC2 is highly expressed in osteosarcoma cells and tissues, and its overexpression promotes viability, invasion of osteosarcoma cells via SHIP2 suppression, and PI3K/AKT activation.
the studies confirm the extent of ZIC2 allelic heterogeneity and that pathogenic variants of ZIC2 are associated with both classic and middle interhemispheric variant (MIHV) HPE which arise from defective ventral and dorsal forebrain patterning, respectively.
miR-1271/Zic2/PAK4 axis plays an important role in hepatocellular carcinoma progression.
Together SMAD3 and ZIC2 regulate FOXA2 transcription in cultured cells and Zic2 also controls the foxA2 expression during Xenopus development. These findings reveal a new mechanism of NODAL signal transduction in the mammalian node and provide the first molecular explanation of how ZIC2 loss-of-function precipitates Holoprosencephaly (HPE
Data show that Zinc finger protein ZIC 2 (ZIC2) is indispensable in the regulation of pancreatic ductal adenocarcinoma (PDAC) cell apoptosis.
ZIC2 acts upstream of OCT4 and recruits the nuclear remodeling factor complex to the OCT4 promoter, initiating OCT4 activation. ZIC2 levels positively correlated to the clinicopathological stages of HCC patients.
Mutational screening for HPE genes revealed the occurrence of a frameshift mutation in the ZIC2 gene.
ZIC2 and RASGRF1 are susceptibility genes, not only for common myopia, but also for high myopia.
The c.1401_1406dup (p.Ala469_470dup) or alanine tract expansion to 17 residues) in the ZIC2 gene are likely to be medically significant for holoprosencephaly in a Brazilian cohort.
A high level of sequence variation in the 3'UTR of ZIC2 may be associated with holoprosencephaly.
ZIC2, a transcription factor related to the sonic hedgehog pathway, is a strong discriminant between MAL and LMP tumors: it may be a major determinant of outcome of EOTs.
Mutations in ZIC2 is associated with holoprosencephaly.
Brain malformations, including neuronal migration defects, predominated in individuals with ZIC2 mutations.
role for ZIC2 as a transcriptional regulator of the beta-catenin.TCF4 complex.
Our findings suggest that Zic2 is a positive modulator increasing Gli1 transcriptional and oncogenic activity by retaining Gli1 in the nucleus of cervical cancer cells.
mutation of ZIC2 is a rare cause of, or contributor to, RES associated with HPE.
ZIC1, ZIC2, and ZIC5 may have roles in meningiomas
the smallest 13q deletion associated to DWM allows further narrowing of the previously established critical region for this brain malformation to 13q32.2-32.3. Among the few genes of the deleted region, ZIC2 and ZIC5 seem the most plausible candidates.
screened four known HPE genes in a Dutch cohort of 86 non-syndromic HPE index cases, including 53 family members. We detected 21 mutations (24.4%), 3 in SHH, 9 in ZIC2 and 9 in SIX3
Holoprosencephaly due to ZIC2 mutations is distinct from that due to mutations in other genes.
these data establish zic2 mutant zebrafish as a powerful new genetic model for in-depth dissection of cell interactions and genetic controls during craniofacial complex development.
Zic2a and Zic2b play a dual role during craniofacial development, in neural crest induction and migration, and in craniofacial chondrogenesis patterning
Zic2a and Zic5 have essential, cooperative roles in promoting cell proliferation in the tectum, but lack obvious patterning functions.
the results identify Zic2a as a novel regulator of prethalamic development, and show that it functions independently of hedgehog signaling.
Zic2a and zic5 as crucial players in the genetic network linking patterned gene expression to morphogenetic changes during neurulation.
These data uncover a novel, essential role for Zic2a as a modulator of Hedgehog-activated gene expression in the developing forebrain
The major acting transcription factors shift from SOX2/POU5F1 in mouse ESCs to ZIC2/OTX2 in EpiSCs, and this shift is primed in ESCs by binding of ZIC2 at relevant genomic positions that later function as enhancers.
Zic2 and Zic1 proteins are essential to control the balance between two defined neuron types in the postnatal forebrain.
This shift in the major acting transcription factors appears to be primed by binding of ZIC2 in embryonic stem cells at relevant genomic positions.
Here, we reveal a previously unknown role for Zic2 in the migration of forebrain neurons such as Cajal-Retzius cells, interneurons moving to the ventral lateral geniculate nucleus, and neocortical cells going to the amygdala.
Zic1 and Zic2 are required for coordinating mature neuronal gene expression patterns.
Zic2 loss-of-function doesn't prevent initial otocyst patterning but leads to molecular abnormalities concomitant with morphogenesis of the endolymphatic duct.
Zic2 is a key factor in the execution of transcriptional fine-tuning with Mbd3/NuRD in embryonic stem cells through interactions with enhancers.
Zic2 appears to be a component of the gene regulatory network that drives ciliation of node cells during gastrulation.
results reveal a Zic2-dependent mechanism, shared by different neural populations, essential to prevent midline crossing during the development of the nervous system.
Explant culture of Zic2(m1Nisw) gastrointestinal tract show extensive neurite outgrowth, suggesting that Zic2 is a negative regulator of nerve fiber growth.
Among three novel missense mutations in ZIC2, R409P was only found in schizophrenia patients, and was located in a strongly conserved position of the zinc finger domain.
Myf5 activation in newly forming somites is delayed in Zic2 mutant embryos until the time of Zic1 activation, and both Zic2 and Myf5 require noggin for their activation
Zic2 is an evolutionarily conserved determinant of retinal ganglion cells that project ipsilaterally
Zic genes are involved in neural crest production and the first demonstration that Zic2 functions during hindbrain patterning.
These results suggest that the physical and functional interaction between Zic and I-mfa proteins can play a role in the vertebrate development.
The C-terminal alanine-tract of ZIC2 influences the strength of DNA binding and alters transcriptional activity in a promoter-specific manner
These results indicated that Zic2 was one of the proteins binding to, and regulating the activity of, the promoter of alpha CaM kinase II.
Zic2 and Zic3 have redundant functions in neurulation as well as other developmental processes
Zic2 mutant embryos fail to express Bmp antagonists dorsally, developing severe spina bifida.
data indicate that Zic2S200 is a target for phosphorylation by DNA-dependent protein kinase, regulating Zic2-mediated transcriptional activation
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
Zic family member 2 (odd-paired homolog, Drosophila)
, Zinc finger protein of the cerebellum 2
, zinc finger protein ZIC 2
, cerebellum zinc finger protein 2
, zinc finger protein of the cerebellum 2
, zinc finger cerebellum 2
, GENA 29
, odd-paired homolog