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Knocking down prefoldin-2 (Pfdn2) expression in primary murine retinal ganglion cells(RGCs) significantly reduced Sncg (show SNCG Proteins) expression, confirming that Pfdn2 regulates Sncg (show SNCG Proteins) expression in murine RGCs.
knockdown of PFD2 and PFD5 (show PFDN5 Proteins) disrupted prefoldin formation in HTT (show HTT Proteins)-expressing cells, resulting in accumulation of aggregates of a pathogenic form of HTT (show HTT Proteins) and in induction of cell death.
Is part of an RNA polymerase II-associated complex with possible chaperone activity.
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.
prefoldin subunit 2
, prefoldin 2