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Knocking down prefoldin-2 (Pfdn2) expression in primary murine retinal ganglion cells(RGCs) significantly reduced Sncg expression, confirming that Pfdn2 regulates Sncg expression in murine RGCs.
prefoldin is amplified at 1q23.3-q24.1 in bladder cancer
knockdown of PFD2 and PFD5 disrupted prefoldin formation in HTT-expressing cells, resulting in accumulation of aggregates of a pathogenic form of HTT and in induction of cell death.
Is part of an RNA polymerase II-associated complex with possible chaperone activity.
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.
prefoldin subunit 2
, prefoldin 2