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CaMKII regulates KCNQ1 at S484 during sustained beta-AR stimulation to inhibit IKs. The ability of CaMKII to inhibit IKs may contribute to arrhythmogenicity during HF.
The importance of CAMK2A and CAMK2B and their auto-phosphorylation in human brain function.
TGFbeta elevated the expression of CamK IIbeta and CamK IIdelta, while siRNA silencing of those two subtypes significantly reduced TGFbeta-mediated expression of collagen A1 and fibronectin 1.
Due to similarity of structure variations, we suggest that these compounds may have an effect on beta-CaMKII and that sengesterone may have a similar efficacy as the control.
beta-carotene reverses the IL-1beta-mediated reduction in paraoxonase-1 expression via induction of the CaMKKII pathway in human endothelial cells
Characterization of a central Ca2+/calmodulin-dependent protein kinase IIalpha/beta binding domain in densin that selectively modulates glutamate receptor subunit phosphorylation.
Promoter methylations of CAMK2B and ARFGEF1 are novel epigenetic markers identified in breast cancer cell lines.
Study presents the crystal structure of an autoinhibited full-length human CaMKII holoenzyme, revealing an unexpected compact arrangement of kinase domains docked against a central hub, with the calmodulin-binding sites completely inaccessible.
The novel cGMP/PKG/ROS/calmodulin/CaMKII signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury.
Four distinct isoforms of CAMKII were isolated. Two of them were characterized as CaMKII alpha and beta subunits.expression is developmentally regulated in both human fetal and adult brain to different degrees
role in cell communication
CaMK II regulates c-FLIP expression and phosphorylation, thus modulating Fas-mediated signaling in glioma cells
exercise increases the activity of CaMKII in skeletal muscle, suggesting that it may have a role in regulating skeletal muscle function and metabolism during exercise in humans
measured differences in CaMKII binding affinities for CaM play a minor role in the autophosphorylation of the enzyme, largely dictated by autophosphorylation rate for alpha, beta, gamma and delta isoforms
the function of CaMK II is essential for PAF-induced macrophage priming, while CaMK IV is not specific for priming by PAF and appears to have a direct link in TLR4-mediated events
presence of a CaMKIIbeta isoform that can target the SR presumably via its membrane anchor alphaKAP defines a previously unrecognized Ca2+/CaM regulatory system in myocardium
thrombomodulin induces Ca2+ signals and nitric oxide synthesis through EGFR and calmodulin kinase II
expression significantly elevated in frontal cortex in schizophrenia & depression; because CaMKIIbeta influences expression of neuroreceptors & neural outgrowth & pruning, altered expression in schizophrenia or depression may contribute to these diseases
regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII.
These FLIM versions of Camui could be useful for elucidating the function of CaMKII both in vitro and in vivo.
Region-specific overexpression of betaCaMKII in dentate gyrus (DG) impairs behavioral flexibility, and severely attenuates the NMDAR-dependent long-term depression (LTD) in DG medial perforant path, which is further confirmed by the diminished AMPAR internalization and dephosphorylation during LTD.
data suggest that phosphorylation of CaMKIIbeta through the mGluR/IP3R1/PKC signaling pathway represses excessive spine formation and elongation in mature Purkinje cells.
The molecular, temporal and region-specific requirements of the CAMK2B in mouse locomotion have been described.
CaMKII is a target of PTENalpha phosphatase and that PTENalpha is an essential element in the molecular regulation of neural activity.
these data implicate the importance of subunit stoichiometry as another regulatory mechanism of PKA activity and lipid metabolism.
Study used an unbiased semiquantitative proteomics approach to identify biologically relevant phosphorylation sites on both CaMKIIa and CaMKIIb
VLDLR requires RasGRF1/CaMKII to alter dendritic spine formation.
CaMKK/CaMK IV pathway is a key endogenous protective mechanism in cerebral ischemia.
Our data point toward a critical role of CaMKIIbeta in regulating oligodendrocyte maturation and CNS myelination via an actin-cytoskeleton-regulatory mechanism
Data suggest that the CaMKIIdeltaB-induced imbalance between NCX1 and SERCA2 is partially responsible for the disturbance of intracellular Ca(2) homeostasis and the pathological process of heart failure.
our data provide compelling support for a model of CaMKII function in which alphaCaMKII and betaCaMKII act in concert, but with distinct functions, to regulate hippocampal synaptic plasticity and learning.
Muscle-specific CamkIIss isoform is critical for receptor recycling and may provide a mechanism by which the postsynaptic acetylcholine receptor density is maintained at the neuromuscular junction in vivo.
is expressed in motor neurons during axon outgrowth and is part of slow axonal transport.
accumulated in the nuclei of brain cells by pentylenetetrazol-mediated seizure via cellular mechanisms other than transcriptional and post-transcriptional regulation
Ca/CaMK II activation plays an important role in the transmission of GnRH signals from the plasma membrane to the LH subunit genes.
Expression of an active form of CaMKII beta after 1 day of T cell activation enhances initial proliferation and cytotoxic T cell activity, but induces profound unresponsiveness to peptide restimulation.
activated CaMKII directly phosphorylated the recombinant COOH-terminal region of FAK at a residue equivalent to Ser-843
CaM kinase IIdelta2 was involved in the GnRH-induced activation of MAP kinase in GT1-7 cells.
These findings uncover a direct mechanism of CaMKII regulation by metabolism and further highlight the importance of metabolism in preserving oocyte viability.
analysis of metabolic regulation of CaMKII protein and caspases in Xenopus laevis egg extracts
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Eight transcript variants encoding eight distinct isoforms have been identified for this gene.
CaM kinase II beta subunit
, CaM-kinase II beta chain
, caMK-II subunit beta
, calcium/calmodulin-dependent protein kinase type II subunit beta
, proline rich calmodulin-dependent protein kinase
, CaMK II
, caM kinase II subunit beta
, calcium/calmodulin-dependent protein kinase II, delta
, Ca++/calmodulin-dependent protein kinase II beta subunit
, caM-kinase II beta chain
, calcium/calmodulin-dependent protein kinase (CaM kinase) II beta
, calcium/calmodulin-dependent protein kinase type II beta chain
, calcium/calmodulin-dependent protein kinase II beta
, calmodulin dependent protein kinase II beta subunit
, calcium/calmodulin-dependent kinase type II beta'-subunit