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anti-Human DAAM1 Antibodies:
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Human Polyclonal DAAM1 Primary Antibody for IHC (p), ELISA - ABIN542914
Lu, Meng, Poy, Maiti, Goode, Eck: Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly. in Journal of molecular biology 2007
Show all 4 Pubmed References
Human Monoclonal DAAM1 Primary Antibody for ELISA, WB - ABIN564982
Kida, Sato, Miyasaka, Suto, Ogura: Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord. in Proceedings of the National Academy of Sciences of the United States of America 2007
Show all 2 Pubmed References
miR-613 is involved in cell migration and invasion of triple-negative breast cancer cells via targeting Daam1/RhoA signaling pathway.
Integrin alphavbeta3-associated DAAM1 is essential for collagen-induced invadopodia extension and cell haptotaxis in breast cancer cells
coiling phagocytosis is a mechanism for borrelial internalization by neuroglial cells mediated by Daam1
Results provide evidence that Daam1 activates RhoA to regulate Wnt5ainduced glioblastoma cell invasion.
DAAM1 organizes actin filaments into a nodal complex
Kank1 plays a crucial role in regulating the activity of RhoA through retrieving excess Daam1 and balancing the activities of RhoA and its effectors.
High Daam-1 expression may upregulate the Wnt/PCP pathway and cause idiopathic pulmonary arterial hypertension
Kif26b, together with Dvl3/Daam1, initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells.
Daam1 plays a dual role in the phagocytic uptake of borreliae.
A developmentally restricted function of miR-490 and its putative DAAM1 target are associated with exaggerated megakaryocytopoiesis and/or proplatelet formation.
Wnt5a promotes breast cancer cell migration via Dvl2/Daam1/RhoA.
DAAM1 is a formin required for centrosome re-orientation during cell migration.
Fli-I promotes the GTP-bound active Rho-mediated relief of the autoinhibition of Daam1 and mDia1. Thus, Fli-I is a novel positive regulator of Rho-induced linear actin assembly mediated by DRFs.
DAAM1 regulates endothelial cell growth through MT stabilization in a cell type-selective manner
DAAM1 was shown to bind to the SH3 domain of CIP4 in vivo.
Results report that Profilin1 is an effector downstream of Daam1 required for cytoskeletal changes during gastrulation.
The DAAM1 FH2 domain structure, determined at 2.25 A resolution, and DAAM1 actin binding activity
Crystal structure of human DAAM1 formin homology 2 domain
a carboxyl-terminal binding partner, Dvl, has a role in activation of Daam1
mDia1 and Daam1 are platelet actin assembly factors having distinct efficiencies, and they are directly regulated by Rho GTPases
The data suggested that Daam1 affected actin assembly during oocyte meiotic division via the regulation of fascin expression.
DAAM1 loss evokes invasive abilities of epithelial cells.
Daam1 knockout mice that were also homozygous for Daam2 had stronger noncompaction cardiomyopathy, severely reduced cardiac function, disrupted sarcomere structure, and increased myocardial proliferation.
Fascin and Daam1 coimmunoprecipitated from cell extracts, and silencing of fascin led to a striking loss of Daam1 localization to filopodial shafts. Purified fascin bound directly to Daam1; fascin recruited Daam1 to and stabilized Daam1 on actin bundles.
Daam1 is important for regulating filamentous actin assembly and organization, and consequently for cytoskeletal function in cardiomyocytes, which contributes to proper heart morphogenesis.
involved in pivotal steps in neuronal cell differentiation and movement
Daams are expressed in tissues known to require Wnts, so effectors of Wnt signaling during vertebrate development.
Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells
Results indicate that Daam1a plays a key role in asymmetric habenular morphogenesis mediating the growth of dendritic and axonal processes in dorsal habenular neurons.
Pronephric tubulogenesis requires the Daam1/WGEF/Rho PCP pathway.
Daam1 is a dynamic coordinator of endocytosis and cytoskeletal remodeling underlying the convergent extension movement of notochord cells.
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins.
disheveled-associated activator of morphogenesis 1
, dishevelled associated activator of morphogenesis 1
, dishevelled-associated activator of morphogenesis 1
, disheveled-associated activator of morphogenesis 1-like
, dishevelled associated activator of morphogenesis 1, like