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anti-Human FZD6 Antibodies:
anti-Rat (Rattus) FZD6 Antibodies:
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Mouse (Murine) Polyclonal FZD6 Primary Antibody for CyTOF, FACS - ABIN4899379
Chang, Smallwood, Williams, Nathans: The spatio-temporal domains of Frizzled6 action in planar polarity control of hair follicle orientation. in Developmental biology 2015
Show all 6 Pubmed References
Human Polyclonal FZD6 Primary Antibody for CyTOF, FACS - ABIN4899378
García-Castro, Alvarez-Zavala, Riveros-Magaña, Ortíz-Lazareno, Ratkovich-González, Hernández-Flores, Bravo-Cuellar, Jave-Suarez, Aguilar-Lemarroy: Restoration of WNT4 inhibits cell growth in leukemia-derived cell lines. in BMC cancer 2013
Study reports a novel pathogenic variant of the FZD6 gene in autosomal recessive nonsyndromic congenital nail (show CD244 Antibodies) disorder in consanguineous Iranian family.
In this paper we report 3 further families with mutations in FZD6 causing Isolated recessive nail (show CD244 Antibodies) dysplasia.
monomeric rather than dimeric form is active signal initiating unit of the receptor complex; constitutive signaling to ERK1/2 can be affected by modulating the dimeric status
the FZD6-fibronectin actin axis identified in our study could be exploited for drug development in highly metastatic forms of breast cancer
we found that FZD6 expression was negatively regulated by miR199a5p
The rs3808553 of FZD6 is obviously associated with neural tube defects in Han population of northern China
This study confirms our speculation that down-regulation of FZD6 by beta-Carotene is causally related to the observed up-regulation of cancer related genes
DVL is a master regulator of FZD6/G-protein signaling
FZD6 should be screened for pachyonychia congenita as it is a candidate gene for hereditary nail (show CD244 Antibodies) dysplasias.
sequence analysis revealed a novel homozygous missense mutation (c.1266G>A; p.Gly422Asp) located in the transmembrane domain of the protein FZD6 in individuals of a consanguineous family exhibiting features of nail (show CD244 Antibodies) dysplasia
Fzd4 (show FZD4 Antibodies) and Fzd6 genes have a deep patterning effect on arterial vessel morphogenesis that may determine its functional efficiency
Eliminating Fz6 in most hair follicle cells or in the inter-follicular epidermis at E15.5 suggests that planar cell polarity signaling in developing follicles is not required to maintain their orientation.
Data show that Wnt receptor, Frizzled-6 (Fzd6) -/- hematopoietic stem/progenitor cell (HSPC (show PSMA7 Antibodies)) exhibit poor emergency hematopoiesis.
Fz3 (show FZD3 Antibodies) and Fz6 have partly interchangeable roles in tissue polarity signaling for epithelial orientation and axon growth and guidance
Fzd6-mediated Wnt (show WNT2 Antibodies) signaling likely regulates the overall differentiation process of nail (show CD244 Antibodies)/claw formation.
Our results support a role of miR (show MLXIP Antibodies)-194 in liver tumorigenesis through its endogenous target Fzd6.
FZD6 mutations can result in severe defects in nail (show CD244 Antibodies) and claw formation through reduced or abolished membranous FZD(6) levels and several nonfunctional WNT (show WNT2 Antibodies)-FZD pathways.
The time course of local hair follicle refinement and the resulting evolution of a montage of competing patterns in Fz6(-/-) skin, is defined.
Downregulated by dietary beta-carotene in lungs of knockout Bcmo1 (show BCMO1 Antibodies)-deficient mice.
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.
, frizzled homolog 6
, frizzled 6
, frizzled 6, seven transmembrane spanning receptor
, seven transmembrane helix receptor
, involved in Wnt signaling, encoding a Wnt receptor